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Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

MedChemComm, 2011-07, Vol.2 (7), p.669

2011

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Palladium-Catalyzed Synthesis of Benzimidazoles and Quinazolinones from Common Precursors

Journal of organic chemistry, 2012-11, Vol.77 (21), p.9473-9486

2012

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Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

Journal of medicinal chemistry, 2017-01, Vol.60 (2), p.767-786

2017

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Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action

Journal of Virology, 2011-07, Vol.85 (13), p.6353-6368

2011

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Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2562-2566

2008

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Cytoprotection by omega-3 fatty acids as a therapeutic drug vehicle when combined with nephrotoxic drugs in an intravenous emulsion: Effects on intraglomerular mesangial cells

Toxicology reports, 2014-01, Vol.1 (C), p.843-857

2014

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Understanding CYP2D6 interactions

Drug discovery today, 2009-10, Vol.14 (19), p.964-972

2009

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Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

Journal of medicinal chemistry, 2016-12, Vol.60 (2)

2016

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The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 1

ChemMedChem, 2014-07, Vol.9 (7), p.1378-1386

2014

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Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity

Bioorganic & medicinal chemistry, 2008-05, Vol.18 (9), p.2896-2899

2008

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[4-(Phenoxy)pyridin-3-yl]methylamines: A new class of selective noradrenaline reuptake inhibitors

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1795-1798

2008

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Design, synthesis and evaluation of N-[(3 S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4579-4583

2009

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4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure–activity relationships

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (10), p.2829-2834

2009

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The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile--Part1

ChemMedChem, 2014-07, Vol.9 (7), p.1378

2014

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Enantioselective synthesis of ( R)- and ( S)- N-Boc-morpholine-2-carboxylic acids by enzyme-catalyzed kinetic resolution: application to the synthesis of reboxetine analogs

Tetrahedron letters, 2009-01, Vol.50 (4), p.389-391

2009

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N-Benzyl- N-(tetrahydro-2 H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.2022-2025

2007

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N-[(3 S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5078-5081

2009

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N-Benzyl- N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4308-4311

2008

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Structure–activity relationships of N-substituted piperazine amine reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4349-4353

2006

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A Novel Cyclisation Strategy for the Synthesis of Lactonamycin: A New Route to Highly Functionalised Heterocyclic Rings

Synlett, 2006-12, Vol.2006 (19), p.3243-3246

2006

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N-(1,2-Diphenylethyl)piperazines: A new class of dual serotonin/noradrenaline reuptake inhibitor

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4345-4348

2006

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Derivatives of (3 S)- N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4355-4359

2008

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Corrigendum to “ N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration” [Bioorg. Med. Chem. Lett. 19 (2009) 5078]

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (2), p.772-772

2010

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Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

Palladium-Catalyzed Synthesis of Benzimidazoles and Quinazolinones from Common Precursors

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition

Cytoprotection by omega-3 fatty acids as a therapeutic drug vehicle when combined with nephrotoxic drugs in an intravenous emulsion: Effects on intraglomerular mesangial cells

Understanding CYP2D6 interactions

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 1

Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 2

[4-(Phenoxy)pyridin-3-yl]methylamines: A new class of selective noradrenaline reuptake inhibitors

Design, synthesis and evaluation of N-[(3 S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template

4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure–activity relationships

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile--Part1

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile--Part2

Enantioselective synthesis of ( R)- and ( S)- N-Boc-morpholine-2-carboxylic acids by enzyme-catalyzed kinetic resolution: application to the synthesis of reboxetine analogs

N-Benzyl- N-(tetrahydro-2 H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors

N-[(3 S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration

N-Benzyl- N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors

Structure–activity relationships of N-substituted piperazine amine reuptake inhibitors

A Novel Cyclisation Strategy for the Synthesis of Lactonamycin: A New Route to Highly Functionalised Heterocyclic Rings

N-(1,2-Diphenylethyl)piperazines: A new class of dual serotonin/noradrenaline reuptake inhibitor

Derivatives of (3 S)- N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity

Corrigendum to “ N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration” [Bioorg. Med. Chem. Lett. 19 (2009) 5078]

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