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Pyridinone Derivatives: Specific Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors with Antiviral Activity

Proceedings of the National Academy of Sciences - PNAS, 1991-08, Vol.88 (15), p.6863-6867

1991

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Diketo Acid Inhibitor Mechanism and HIV-1 Integrase: Implications for Metal Binding in the Active Site of Phosphotransferase Enzymes

Proceedings of the National Academy of Sciences - PNAS, 2002-05, Vol.99 (10), p.6661-6666

2002

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Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells

Journal of medicinal chemistry, 2003-02, Vol.46 (4), p.453-456

2003

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2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2922-2925

1991

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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogs of 3-aminopyridin-2(1H)-one

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3792-3802

1992

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Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (17), p.1943-1948

2000

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P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes

Biochemical pharmacology, 2001-09, Vol.62 (6), p.773-776

2001

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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogs

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3784-3791

1992

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A Naphthyridine Carboxamide Provides Evidence for Discordant Resistance between Mechanistically Identical Inhibitors of HIV-1 Integrase

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (31), p.11233-11238

2004

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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogs

Journal of medicinal chemistry, 1993-04, Vol.36 (8), p.953-966

1993

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Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

Science (American Association for the Advancement of Science), 2004-07, Vol.305 (5683), p.528-532

2004

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4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

Journal of medicinal chemistry, 2000-12, Vol.43 (26), p.4923-4926

2000

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Inhibition of HIV-1 Ribonuclease H by a Novel Diketo Acid, 4-[5-(Benzoylamino)thien-2-yl]-2,4-dioxobutanoic Acid

The Journal of biological chemistry, 2003-01, Vol.278 (5), p.2777-2780

2003

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Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one

Journal of medicinal chemistry, 1993, Vol.36 (2), p.249-255

1993

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A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (20), p.4550-4554

2005

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A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (11), p.2900-2904

2006

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Synthesis of 3-Alkyl-6-bromo-4,5-E-hexenoate

Synthetic communications, 1996-09, Vol.26 (18), p.3431-3442

1996

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A mechanistic insight leads to a greatly improved osmium-catalyzed asymmetric dihydroxylation process

Journal of the American Chemical Society, 1989-02, Vol.111 (3), p.1123-1125

1989

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Inhibition of HIV-1 Ribonuclease H by a Novel Diketo Acid, 4-(5-(Benzoylamino)thien-2-yl)-2,4-dioxobutanoic Acid

The Journal of biological chemistry, 2003-01, Vol.278 (5), p.2777-2780

2003

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Synthesis and biological activity of ras farnesyl protein transferase inhibitors. Tetrapeptide analogs with amino methyl and carbon linkages

Bioorganic & medicinal chemistry, 1994-09, Vol.2 (9), p.939-947

1994

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Documenting the scope of the catalytic asymmetric dihydroxylation

Tetrahedron letters, 1989, Vol.30 (16), p.2041-2044

1989

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Fatty acids: XXIII. A rapid method for the preparation of C18 furanoid fatty ester involving dry‐column chromatography

Journal of the American Oil Chemists' Society, 1981-06, Vol.58 (6), p.705-706

1981

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Rapid and efficient reprogramming of human fetal and adult blood CD34~ cells into mesenchymal stem cells with a single factor

Cell research, 2013-05, Vol.23 (5), p.658-672

2013

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Preparation of 3-amino-1,4-benzodiazepin-2-ones via direct azidation with trisyl azide

Tetrahedron letters, 1996-09, Vol.37 (37), p.6685-6688

1996

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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-(2-(benzoxazol-2-yl)ethyl)-5-ethyl-6-methylpyridin-2(1H)-one and analogues

Journal of medicinal chemistry, 1993-01, Vol.36 (8), p.953-966

1993

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