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P0688 : Preclinical characterisation of MIV-802, a novel uridine nucleotide HCV NS5B polymerase inhibitor, for treatment of hepatitis C virus infection

Journal of hepatology, 2015-04, Vol.62, p.S580-S580

2015

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Effect of the selective cathepsin K inhibitor MIV-711 on bone resorption and cartilage degradation biomarkers and on knee joint pathology in dogs subjected to partial medial meniscectomy, an experimental model of osteoarthritis

Bone (New York, N.Y.), 2012-05, Vol.50, p.S188-S189

2012

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Pharmacological characterization of the potent, selective and orally active cathepsin K inhibitor MIV-711

Bone (New York, N.Y.), 2012-05, Vol.50, p.S164-S165

2012

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Cathepsin K inhibitors for the treatment of bone metastasis

Bone (New York, N.Y.), 2011-01, Vol.48 (1), p.S51-S51

2011

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112 EFFECT OF THE SELECTIVE CATHEPSIN K INHIBITOR, MIV-711, ON MARKERS OF CARTILAGE DEGRADATION AND ON GROSS AND HISTOPATHOLOGY SCORES IN DOGS SUBJECTED TO PARTIAL MEDIAL MENISCECTOMY, AN EXPERIMENTAL MODEL OF OSTEOARTHRITIS

Osteoarthritis and cartilage, 2011-09, Vol.19, p.S59-S59

2011

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Solid-phase library synthesis of reversed-statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II

Bioorganic & medicinal chemistry, 2003-03, Vol.11 (6), p.827-841

2003

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New inhibitors of the malaria aspartyl proteases plasmepsin I and II

Bioorganic & medicinal chemistry, 2003-08, Vol.11 (16), p.3423-3437

2003

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Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy

European journal of biochemistry, 2004-11, Vol.271 (22), p.4594-4602

2004

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Optimization of P1–P3 groups in symmetric and asymmetric HIV‐1 protease inhibitors

European journal of biochemistry, 2003-04, Vol.270 (8), p.1746-1758

2003

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Anti-HIV type 1 activity of 3'-fluoro-3'-deoxythymidine for several different multidrug-resistant mutants

AIDS research and human retroviruses, 2001-03, Vol.17 (5), p.401-407

2001

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Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs

Antimicrobial Agents and Chemotherapy, 1997-11, Vol.41 (11), p.2383-2388

1997

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A0898 - DaBlaCa-16: The MOSAIC trial - A randomized study investigating retrosigmoid versus conventional ileal conduit in robot-assisted radical cystectomy - feasibility and 90-day postoperative complications

European urology, 2024-03, Vol.85, p.S1945-S1946

2024

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DaBlaCa-16: The MOSAIC trial - A randomized study investigating retrosigmoid versus conventional ileal conduit in robot-assisted radical cystectomy - feasibility and 90-day postoperative complications

European urology, 2024-03, Vol.85, p.S1945-S1946

2024

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Human Immunodeficiency Virus Type 1 (HIV-1) Strains Selected for Resistance Against the HIV-1-Specific [2',5'-Bis-O-(Tert-Butyldimethylsilyl)-3'- Spiro-5''-(4''-Amino-1'',2''-Oxathiole-2'',2''-Dioxide)]-β-D- Pentofuranosyl (TSAO) Nucleoside Analogues Retain Sensitivity to HIV-1- Specific Nonnucleoside Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 1993-08, Vol.90 (15), p.6952-6956

1993

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Design and Synthesis of Plasmepsin I and Plasmepsin II Inhibitors with Activity in Plasmodium falciparum-Infected Cultured Human Erythrocytes

Journal of medicinal chemistry, 2003-02, Vol.46 (5), p.734-746

2003

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Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2′ to P1/P1

Bioorganic & medicinal chemistry, 2005-02, Vol.13 (3), p.755-764

2005

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Fast and selective synthesis of novel cyclic sulfamide HIV-1 protease inhibitors under controlled microwave heating

Tetrahedron, 2006-05, Vol.62 (19), p.4671-4675

2006

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PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase

Antimicrobial Agents and Chemotherapy, 1986-05, Vol.29 (5), p.867-872

1986

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Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II

Bioorganic & medicinal chemistry, 2005-09, Vol.13 (18), p.5371-5390

2005

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Phenethylthiazolethiourea (PETT) Compounds, a New Class of HIV-1 Reverse Transcriptase Inhibitors. 1. Synthesis and Basic Structure-Activity Relationship Studies of PETT Analogs

Journal of medicinal chemistry, 1995-12, Vol.38 (25), p.4929-4936

1995

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Improved Structure−Activity Relationship Analysis of HIV-1 Protease Inhibitors Using Interaction Kinetic Data

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.5953-5961

2004

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Design and Synthesis of Potent Inhibitors of the Malaria Aspartyl Proteases Plasmepsin I and II. Use of Solid-Phase Synthesis to Explore Novel Statine Motifs

Journal of medicinal chemistry, 2004-06, Vol.47 (13), p.3353-3366

2004

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Design and Synthesis of Potent Inhibitors of Plasmepsin I and II: X-ray Crystal Structure of Inhibitor in Complex with Plasmepsin II

Journal of medicinal chemistry, 2005-06, Vol.48 (13), p.4400-4409

2005

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Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet

Antimicrobial Agents and Chemotherapy, 1989-05, Vol.33 (5), p.778-780

1989

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New potent C 2 -Symmetric malaria plasmepsin I and II inhibitors

Bioorganic & medicinal chemistry, 2003-04, Vol.11 (7), p.1235-1246

2003

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P0688 : Preclinical characterisation of MIV-802, a novel uridine nucleotide HCV NS5B polymerase inhibitor, for treatment of hepatitis C virus infection

Effect of the selective cathepsin K inhibitor MIV-711 on bone resorption and cartilage degradation biomarkers and on knee joint pathology in dogs subjected to partial medial meniscectomy, an experimental model of osteoarthritis

Pharmacological characterization of the potent, selective and orally active cathepsin K inhibitor MIV-711

Cathepsin K inhibitors for the treatment of bone metastasis

112 EFFECT OF THE SELECTIVE CATHEPSIN K INHIBITOR, MIV-711, ON MARKERS OF CARTILAGE DEGRADATION AND ON GROSS AND HISTOPATHOLOGY SCORES IN DOGS SUBJECTED TO PARTIAL MEDIAL MENISCECTOMY, AN EXPERIMENTAL MODEL OF OSTEOARTHRITIS

Solid-phase library synthesis of reversed-statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II

New inhibitors of the malaria aspartyl proteases plasmepsin I and II

Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy

Optimization of P1–P3 groups in symmetric and asymmetric HIV‐1 protease inhibitors

Anti-HIV type 1 activity of 3'-fluoro-3'-deoxythymidine for several different multidrug-resistant mutants

Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs

A0898 - DaBlaCa-16: The MOSAIC trial - A randomized study investigating retrosigmoid versus conventional ileal conduit in robot-assisted radical cystectomy - feasibility and 90-day postoperative complications

DaBlaCa-16: The MOSAIC trial - A randomized study investigating retrosigmoid versus conventional ileal conduit in robot-assisted radical cystectomy - feasibility and 90-day postoperative complications

Design and Synthesis of Plasmepsin I and Plasmepsin II Inhibitors with Activity in Plasmodium falciparum-Infected Cultured Human Erythrocytes

Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2′ to P1/P1

Fast and selective synthesis of novel cyclic sulfamide HIV-1 protease inhibitors under controlled microwave heating

PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase

Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II

Phenethylthiazolethiourea (PETT) Compounds, a New Class of HIV-1 Reverse Transcriptase Inhibitors. 1. Synthesis and Basic Structure-Activity Relationship Studies of PETT Analogs

Improved Structure−Activity Relationship Analysis of HIV-1 Protease Inhibitors Using Interaction Kinetic Data

Design and Synthesis of Potent Inhibitors of the Malaria Aspartyl Proteases Plasmepsin I and II. Use of Solid-Phase Synthesis to Explore Novel Statine Motifs

Design and Synthesis of Potent Inhibitors of Plasmepsin I and II: X-ray Crystal Structure of Inhibitor in Complex with Plasmepsin II

Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet

New potent C 2 -Symmetric malaria plasmepsin I and II inhibitors

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