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Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease

Scientific reports, 2021-09, Vol.11 (1), p.19422-19422, Article 19422

2021

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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1247-1261

2017

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The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4867-4880

2016

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Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease

PloS one, 2019-04, Vol.14 (4), p.e0215033-e0215033

2019

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Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2‑((4-(Benzo[d]thiazol-5-ylamino)-6‑(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases

Journal of medicinal chemistry, 2019-07, Vol.62 (14), p.6482-6494

2019

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Reciprocal Regulation of Aquaporin-2 Abundance and Degradation by Protein Kinase A and p38-MAP Kinase

Journal of the American Society of Nephrology, 2010-10, Vol.21 (10), p.1645-1656

2010

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Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation

Cell reports (Cambridge), 2019-04, Vol.27 (5), p.1461-1471.e4

2019

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Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease

Scientific reports, 2018-03, Vol.8 (1), p.4941-13, Article 4941

2018

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Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients

Scientific reports, 2019-10, Vol.9 (1), p.14042-12, Article 14042

2019

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Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system

Journal of inflammation (London, England), 2011-05, Vol.8 (1), p.11-11

2011

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Transitional B Cells: How Well Are the Checkpoints for Specificity Understood?

Archivum Immunologiae et Therapiae Experimentalis, 2011-10, Vol.59 (5), p.379-384

2011

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Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells

American Journal of Physiology: Cell Physiology, 2007-09, Vol.293 (3), p.C1129-C1138

2007

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Flow Cytometry Reveals the Nature of Oncotic Cells

International journal of molecular sciences, 2019-09, Vol.20 (18), p.4379

2019

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Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

Cell reports (Cambridge), 2019-06, Vol.27 (13), p.3956-3971.e6

2019

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Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Communications biology, 2020-03, Vol.3 (1), p.140, Article 140

2020

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Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients With Inflammatory Bowel Disease

Gastroenterology (New York, N.Y. 1943), 2015-11, Vol.149 (6), p.1564-1574.e3

2015

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Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation

Gastroenterology (New York, N.Y. 1943), 2015-08, Vol.149 (2), p.456-467.e15

2015

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A role for gut-associated lymphoid tissue in shaping the human B cell repertoire

The Journal of experimental medicine, 2013-08, Vol.210 (9), p.1665-1674

2013

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Reduced CD27 - IgD - B Cells in Blood and Raised CD27 - IgD - B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease

Frontiers in immunology, 2019-03, Vol.10, p.361

2019

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A CD3-Specific Antibody Reduces Cytokine Production and Alters Phosphoprotein Profiles in Intestinal Tissues From Patients With Inflammatory Bowel Disease

Gastroenterology (New York, N.Y. 1943), 2014-07, Vol.147 (1), p.172-183

2014

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Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE

The Journal of immunology (1950), 2010-10, Vol.185 (7), p.4118-4127

2010

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Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells

The Journal of immunology (1950), 2013-09, Vol.191 (5), p.2752-2763

2013

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Sa1751 Interleukin-6 Drives Production of Pathogenic Cytokines by Innate Lymphoid Cells in Patients and Mice With Chronic Intestinal Inflammation

Gastroenterology (New York, N.Y. 1943), 2015-04, Vol.148 (4), p.S-323-S-323

2015

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Colonic Lymphoid Nodular Hyperplasia in an Adolescent

Journal of pediatric gastroenterology and nutrition, 2011-12, Vol.53 (6), p.684-686

2011

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Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2‑((4-(Benzo[d]thiazol-5-ylamino)-6‑(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases

Reciprocal Regulation of Aquaporin-2 Abundance and Degradation by Protein Kinase A and p38-MAP Kinase

Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation

Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease

Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients

Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system

Transitional B Cells: How Well Are the Checkpoints for Specificity Understood?

Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells

Flow Cytometry Reveals the Nature of Oncotic Cells

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease

Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients With Inflammatory Bowel Disease

Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation

A role for gut-associated lymphoid tissue in shaping the human B cell repertoire

Reduced CD27 - IgD - B Cells in Blood and Raised CD27 - IgD - B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease

A CD3-Specific Antibody Reduces Cytokine Production and Alters Phosphoprotein Profiles in Intestinal Tissues From Patients With Inflammatory Bowel Disease

Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE

Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells

Sa1751 Interleukin-6 Drives Production of Pathogenic Cytokines by Innate Lymphoid Cells in Patients and Mice With Chronic Intestinal Inflammation

Colonic Lymphoid Nodular Hyperplasia in an Adolescent

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