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Kinases as therapeutic targets for heart failure

Nature reviews. Drug discovery, 2003-02, Vol.2 (2), p.99-113

2003

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Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes

Diabetes (New York, N.Y.), 2002-09, Vol.51 (9), p.2709-2718

2002

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An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model

International immunopharmacology, 2005-03, Vol.5 (3), p.495-502

2005

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Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity

American Journal of Physiology: Cell Physiology, 2003-06, Vol.284 (6), p.C1645-C1653

2003

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A cell-based immunocytochemical assay for monitoring kinase signaling pathways and drug efficacy

Analytical biochemistry, 2005-03, Vol.338 (1), p.136-142

2005

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Complete Inhibition of Anisomycin and UV Radiation but Not Cytokine Induced JNK and p38 Activation by an Aryl-substituted Dihydropyrrolopyrazole Quinoline and Mixed Lineage Kinase 7 Small Interfering RNA

The Journal of biological chemistry, 2005-05, Vol.280 (19), p.19298-19305

2005

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Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling

Critical care medicine, 2004-05, Vol.32 (5 Suppl), p.S302-S308

2004

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Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption

American Journal of Physiology: Cell Physiology, 1999-09, Vol.277 (3), p.C531-C536

1999

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Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: A possible explanation for impaired collateral formation in cardiac tissue

Circulation (New York, N.Y.), 2002-01, Vol.105 (3), p.373-379

2002

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Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells

American journal of physiology: endocrinology and metabolism, 1998-04, Vol.274 (4), p.E611-E617

1998

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Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

Circulation (New York, N.Y.), 1999-01, Vol.99 (3), p.384-391

1999

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Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis

Blood, 2007-01, Vol.109 (2), p.560-565

2007

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Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs

Journal of medicinal chemistry, 1996-03, Vol.39 (5), p.1106-1111

1996

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Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation

Biochemical and biophysical research communications, 2008-03, Vol.367 (3), p.642-648

2008

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Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase

Cancer research (Chicago, Ill.), 1994-05, Vol.54 (9), p.2419-2423

1994

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Role of PRL-3, a Human Muscle-Specific Tyrosine Phosphatase, in Angiotensin-II Signaling

Biochemical and biophysical research communications, 2001-05, Vol.283 (5), p.1061-1068

2001

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Calmodulin Activates Phosphatidylinositol 3-Kinase

The Journal of biological chemistry, 1997-11, Vol.272 (45), p.28183-28186

1997

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Synthesis and in Vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3-Kinase

Journal of medicinal chemistry, 1996-12, Vol.39 (25), p.5021-5024

1996

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Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2518-2521

2006

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The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs

Biochemical and biophysical research communications, 1992-07, Vol.186 (2), p.624-631

1992

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LY-294002-inhibitable PI 3-kinase and regulation of baseline rates of Na+ transport in A6 epithelia

American Journal of Physiology: Cell Physiology, 2000-07, Vol.279 (1), p.C236-C247

2000

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Phosphoinositide 3-kinase regulates excitation-contraction coupling in neonatal cardiomyocytes

American journal of physiology. Heart and circulatory physiology, 2004-02, Vol.286 (2), p.H796-H805

2004

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

The Journal of biological chemistry, 1994-02, Vol.269 (7), p.5241-5248

1994

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Inhibitors of cellular signaling targets: designs and limitations

Methods in molecular biology (Clifton, N.J.), 2004, Vol.273, p.87

2004

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Protein kinase C βII activation induces angiotensin converting enzyme expression in neonatal rat cardiomyocytes

Cardiovascular research, 2003, Vol.57 (1), p.139-146

2003

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Kinases as therapeutic targets for heart failure

Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes

An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model

Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity

A cell-based immunocytochemical assay for monitoring kinase signaling pathways and drug efficacy

Complete Inhibition of Anisomycin and UV Radiation but Not Cytokine Induced JNK and p38 Activation by an Aryl-substituted Dihydropyrrolopyrazole Quinoline and Mixed Lineage Kinase 7 Small Interfering RNA

Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling

Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption

Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: A possible explanation for impaired collateral formation in cardiac tissue

Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis

Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs

Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase

Role of PRL-3, a Human Muscle-Specific Tyrosine Phosphatase, in Angiotensin-II Signaling

Calmodulin Activates Phosphatidylinositol 3-Kinase

Synthesis and in Vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3-Kinase

Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase

The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs

LY-294002-inhibitable PI 3-kinase and regulation of baseline rates of Na+ transport in A6 epithelia

Phosphoinositide 3-kinase regulates excitation-contraction coupling in neonatal cardiomyocytes

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

Inhibitors of cellular signaling targets: designs and limitations

Protein kinase C βII activation induces angiotensin converting enzyme expression in neonatal rat cardiomyocytes

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