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Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases

Nitric oxide, 2018-09, Vol.79, p.31-37

2018

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Electrophilic fatty acid nitroalkenes are systemically transported and distributed upon esterification to complex lipids[S]

Journal of lipid research, 2019-02, Vol.60 (2), p.388-399

2019

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Conjugated Linoleic Acid Is a Preferential Substrate for Fatty Acid Nitration

The Journal of biological chemistry, 2012-12, Vol.287 (53), p.44071-44082

2012

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Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride

Nature chemical biology, 2015-07, Vol.11 (7), p.504-510

2015

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Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans

Scientific reports, 2017-01, Vol.7 (1), p.39900, Article 39900

2017

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mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (26), p.10764-10769

2009

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Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine[S]

Journal of lipid research, 2013-07, Vol.54 (7), p.1998-2009

2013

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In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation

Redox biology, 2018-05, Vol.15 (C), p.522-531

2018

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Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis

Redox biology, 2019-02, Vol.21, p.101050-101050, Article 101050

2019

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Hemin and iron increase synthesis and trigger export of xanthine oxidoreductase from hepatocytes to the circulation

Redox biology, 2023-11, Vol.67, p.102866-102866, Article 102866

2023

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Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis

Redox biology, 2023-06, Vol.62, p.102636-102636, Article 102636

2023

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Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO2) and nitroalkene (RNO2) substituents

Redox biology, 2021-05, Vol.41, p.101913-101913, Article 101913

2021

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Nitrite elicits divergent NO-dependent signaling that associates with outcome in out of hospital cardiac arrest

Redox biology, 2020-05, Vol.32, p.101463-101463, Article 101463

2020

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Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation

American journal of physiology. Heart and circulatory physiology, 2009-05, Vol.296 (5), p.H1398-H1407

2009

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Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice

Blood advances, 2019-12, Vol.3 (23), p.4104-4116

2019

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3329 Hemoglobin selectively inhibits renal proximal tubular uptake of proteins: Implications for vitamin D deficiency and kidney disease in sickle cell disease

Journal of clinical and translational science, 2019-03, Vol.3 (s1), p.12-13

2019

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Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction

Biochemical journal, 2009-09, Vol.422 (3), p.423-432

2009

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Hemopexin deficiency promotes acute kidney injury in sickle cell disease

Blood, 2020-03, Vol.135 (13), p.1044-1048

2020

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Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes

Free radical biology & medicine, 2015-12, Vol.89, p.333-341

2015

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Nitro-fatty acids as activators of hSIRT6 deacetylase activity

The Journal of biological chemistry, 2020-12, Vol.295 (52), p.18355-18366

2020

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Hemoglobin alters vitamin carrier uptake and vitamin D metabolism in proximal tubule cells: implications for sickle cell disease

American Journal of Physiology: Cell Physiology, 2019-11, Vol.317 (5), p.C993-C1000

2019

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Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy

Free radical biology & medicine, 2011-08, Vol.51 (4), p.805-812

2011

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The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid

The Journal of biological chemistry, 2017-01, Vol.292 (4), p.1145-1159

2017

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Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease

Arteriosclerosis, thrombosis, and vascular biology, 2021-02, Vol.41 (2), p.769-782

2021

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Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase

The Journal of biological chemistry, 2013-08, Vol.288 (35), p.25626-25637

2013

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Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases

Electrophilic fatty acid nitroalkenes are systemically transported and distributed upon esterification to complex lipids[S]

Conjugated Linoleic Acid Is a Preferential Substrate for Fatty Acid Nitration

Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride

Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans

mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine[S]

In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation

Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis

Hemin and iron increase synthesis and trigger export of xanthine oxidoreductase from hepatocytes to the circulation

Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis

Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO2) and nitroalkene (RNO2) substituents

Nitrite elicits divergent NO-dependent signaling that associates with outcome in out of hospital cardiac arrest

Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation

Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice

3329 Hemoglobin selectively inhibits renal proximal tubular uptake of proteins: Implications for vitamin D deficiency and kidney disease in sickle cell disease

Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction

Hemopexin deficiency promotes acute kidney injury in sickle cell disease

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes

Nitro-fatty acids as activators of hSIRT6 deacetylase activity

Hemoglobin alters vitamin carrier uptake and vitamin D metabolism in proximal tubule cells: implications for sickle cell disease

Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy

The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid

Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease

Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase

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