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Gene Expression Analysis of Murine and Human Osteoarthritis Synovium Reveals Elevation of Transforming Growth Factor β–Responsive Genes in Osteoarthritis‐Related Fibrosis

Arthritis & rheumatology (Hoboken, N.J.), 2014-03, Vol.66 (3), p.647-656

2014

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TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

Osteoarthritis and cartilage, 2015-03, Vol.23 (3), p.478-486

2015

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TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?

Arthritis research & therapy, 2020-03, Vol.22 (1), p.42-42, Article 42

2020

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Expression of transforming growth factor-β (TGFβ) and the TGFβ signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation

Annals of the rheumatic diseases, 2006-11, Vol.65 (11), p.1414-1421

2006

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Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression

Osteoarthritis and cartilage, 2013-01, Vol.21 (1), p.157-164

2013

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Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage

Annals of the rheumatic diseases, 2015-06, Vol.74 (6), p.1257-1264

2015

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Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity

Arthritis research & therapy, 2005, Vol.7 (6), p.R1338-R1347

2005

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Il37 rescues human oa cartilage explants from glycosaminoglycan release

Osteoarthritis and cartilage, 2017-04, Vol.25, p.S148-S148

2017

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Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice

Annals of the rheumatic diseases, 2002-12, Vol.61 (12), p.1095-1098

2002

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AB0119 BMP-9 induces both SMAD1/5/8 and SMAD2/3 phosphorylation, and specific response genes, in chondrocytes

Annals of the rheumatic diseases, 2013-06, Vol.71 (Suppl 3), p.644-644

2013

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Elucidation of IL-1/TGF-β interactions in mouse chondrocyte cell line by genome-wide gene expression

Osteoarthritis and cartilage, 2005-05, Vol.13 (5), p.426-438

2005

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Differential effects of bone morphogenetic protein 2 and 9 on chondroprotective transforming growth factor B signaling

Osteoarthritis and cartilage, 2013-04, Vol.21, p.S124-S124

2013

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BMP-9 induces both smad1/5/8 and Smad2/3 phosphorylation, and specific response genes, in chondrocytes

Osteoarthritis and cartilage, 2012-04, Vol.20, p.S133-S133

2012

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102 LYSYL HYDROXYLASE 2B IS STRONGLY INDUCED DURING EXPERIMENTAL OA AND THE POTENTIAL CAUSE OF PERSISTENT SYNOVIAL FIBROSIS

Osteoarthritis and cartilage, 2011-09, Vol.19, p.S54-S54

2011

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Osteoarthritis-associated fibrosis is related with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression

Osteoarthritis and cartilage, 2012-04, Vol.20, p.S54-S55

2012

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AB1149 MONOCYTES DRIVE MYOFIBROBLAST CONTRACTION IN A 3D SKIN MODEL USED TO UNDERSTAND FIBROSIS IN SYSTEMIC SCLEROSIS

Annals of the rheumatic diseases, 2024-06, Vol.83 (Suppl 1), p.1907-1908

2024

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Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints

Laboratory investigation, 1998-02, Vol.78 (2), p.133

1998

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AB0139 DEEP IMMUNE PHENOTYPING OF T LYMPHOCYTE SUBSETS IN SYSTEMIC SCLEROSIS PATHOPHYSIOLOGY AND FOLLOWING RESPONSE TO TARGETED CYTOTOXIC TREATMENT

Annals of the rheumatic diseases, 2022-06, Vol.81 (Suppl 1), p.1199-1199

2022

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OP0112 EXPANSION OF ACTIVATED CD7+ CYTOTOXIC T CELLS AND NK CELLS IN SSC AND PREVENTION OF FIBROBLAST CONTRACTION THROUGH SELECTIVE IMMUNOTOXIN-MEDIATED DEPLETION OF THESE CELLS

Annals of the rheumatic diseases, 2023-06, Vol.82 (Suppl 1), p.74-75

2023

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OP0097 PROOF-OF-CONCEPT OF FIBROBLAST-TARGETED PHOTODYNAMIC THERAPY IN HUMAN 3D SCLERODERMA SKIN MODEL AND BLEOMYCIN-INDUCED SKIN FIBROSIS IN MICE

Annals of the rheumatic diseases, 2022-06, Vol.81 (Suppl 1), p.64-65

2022

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AB0053 A bioassay to measure tgfΒ activity reveals decreased tgfΒ activity in ssc serum

Annals of the rheumatic diseases, 2018-06, Vol.77 (Suppl 2), p.1226

2018

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AB0053 A bioassay to measure tgf[BETA] activity reveals decreased tgf[BETA] activity in ssc serum

Annals of the rheumatic diseases, 2018-06, Vol.77, p.1226

2018

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Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-β-mediated chondrocyte proliferation and proteoglycan synthesis

Osteoarthritis and cartilage, 2003-11, Vol.11 (11), p.773-782

2003

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P076 A bioassay to measure tgf[BETA] activity reveals decreased tgf[BETA] activity in systemic sclerosis serum

Annals of the rheumatic diseases, 2018-03, Vol.77, p.A45

2018

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P076 A bioassay to measure tgfΒ activity reveals decreased tgfΒ activity in systemic sclerosis serum

Annals of the rheumatic diseases, 2018-03, Vol.77 (Suppl 1), p.A45

2018

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Gene Expression Analysis of Murine and Human Osteoarthritis Synovium Reveals Elevation of Transforming Growth Factor β–Responsive Genes in Osteoarthritis‐Related Fibrosis

TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?

Expression of transforming growth factor-β (TGFβ) and the TGFβ signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation

Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression

Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage

Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity

Il37 rescues human oa cartilage explants from glycosaminoglycan release

Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice

AB0119 BMP-9 induces both SMAD1/5/8 and SMAD2/3 phosphorylation, and specific response genes, in chondrocytes

Elucidation of IL-1/TGF-β interactions in mouse chondrocyte cell line by genome-wide gene expression

Differential effects of bone morphogenetic protein 2 and 9 on chondroprotective transforming growth factor B signaling

BMP-9 induces both smad1/5/8 and Smad2/3 phosphorylation, and specific response genes, in chondrocytes

102 LYSYL HYDROXYLASE 2B IS STRONGLY INDUCED DURING EXPERIMENTAL OA AND THE POTENTIAL CAUSE OF PERSISTENT SYNOVIAL FIBROSIS

Osteoarthritis-associated fibrosis is related with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression

AB1149 MONOCYTES DRIVE MYOFIBROBLAST CONTRACTION IN A 3D SKIN MODEL USED TO UNDERSTAND FIBROSIS IN SYSTEMIC SCLEROSIS

Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints

AB0139 DEEP IMMUNE PHENOTYPING OF T LYMPHOCYTE SUBSETS IN SYSTEMIC SCLEROSIS PATHOPHYSIOLOGY AND FOLLOWING RESPONSE TO TARGETED CYTOTOXIC TREATMENT

OP0112 EXPANSION OF ACTIVATED CD7+ CYTOTOXIC T CELLS AND NK CELLS IN SSC AND PREVENTION OF FIBROBLAST CONTRACTION THROUGH SELECTIVE IMMUNOTOXIN-MEDIATED DEPLETION OF THESE CELLS

OP0097 PROOF-OF-CONCEPT OF FIBROBLAST-TARGETED PHOTODYNAMIC THERAPY IN HUMAN 3D SCLERODERMA SKIN MODEL AND BLEOMYCIN-INDUCED SKIN FIBROSIS IN MICE

AB0053 A bioassay to measure tgfΒ activity reveals decreased tgfΒ activity in ssc serum

AB0053 A bioassay to measure tgf[BETA] activity reveals decreased tgf[BETA] activity in ssc serum

Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-β-mediated chondrocyte proliferation and proteoglycan synthesis

P076 A bioassay to measure tgf[BETA] activity reveals decreased tgf[BETA] activity in systemic sclerosis serum

P076 A bioassay to measure tgfΒ activity reveals decreased tgfΒ activity in systemic sclerosis serum

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