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Synthesis of Best-Seller Drugs

1, 2016

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The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases

Current protein & peptide science, 2016-01, Vol.17 (5), p.488-496

2016

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Cyclic Opioid Peptides

Current medicinal chemistry, 2016-01, Vol.23 (13), p.1288-1303

2016

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Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction

Peptides (New York, N.Y. : 1980), 2019-06, Vol.116, p.63-67

Hruby, Victor J.

2019

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Peptidomimetics, a synthetic tool of drug discovery

Current opinion in chemical biology, 2008-06, Vol.12 (3), p.292-296

2008

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Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

Future medicinal chemistry, 2014-03, Vol.6 (4), p.385-412

2014

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MC4R biased signalling and the conformational basis of biological function selections

Journal of cellular and molecular medicine, 2022-08, Vol.26 (15), p.4125-4136

2022

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Synthesis of Essential Drugs

1, 2006

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Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors

Biopolymers, 2016-11, Vol.106 (6), p.884-888

Hruby, Victor J.

2016

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Designing peptide receptor agonists and antagonists

Nature reviews. Drug discovery, 2002-11, Vol.1 (11), p.847-858

Hruby, Victor J

2002

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Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH 2 Lead to Potent and Selective Agonists at hMC1R and hMC4R

Journal of medicinal chemistry, 2023-05, Vol.66 (10), p.6715-6724

2023

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Design of cyclized selective melanotropins

Biopolymers, 2016-11, Vol.106 (6), p.876-883

2016

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Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice

European journal of pharmacology, 2020-08, Vol.880, p.173186-173186, Article 173186

2020

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Ψ and χ Angle Constrains at the C‑Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His‑d‑Phe-Arg-Trp-NH2 Lead to Potent and Selective Agonists at hMC1R and hMC4R

Journal of medicinal chemistry, 2023-05, Vol.66 (10), p.6715-6724

2023

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Cancer vaccine adjuvants - recent clinical progress and future perspectives

Immunopharmacology and immunotoxicology, 2015-02, Vol.37 (1), p.1-11

2015

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Design of Peptide and Peptidomimetic Ligands with Novel Pharmacological Activity Profiles

Annual review of pharmacology and toxicology, 2013-01, Vol.53 (1), p.557-580

2013

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Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions

Molecules (Basel, Switzerland), 2021-10, Vol.26 (20), p.6266

2021

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Development of N -Acetylated Dipalmitoyl- S -Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists

Molecules (Basel, Switzerland), 2019-09, Vol.24 (19), p.3512

2019

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Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics

ACS chemical neuroscience, 2017-06, Vol.8 (6), p.1147-1158

2017

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Cu(I)–Pd(II)-Catalyzed Cycloaddition–Fusion of 1-Iodoalkynes and Azides: One-Pot Synthesis of Fused Tricyclic Heterosystems

Synlett, 2014-08, Vol.25 (17), p.2463-2466

2014

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Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice

Journal of medicinal chemistry, 2018-07, Vol.61 (14), p.6075-6086

2018

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C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters

Bioorganic & medicinal chemistry, 2021-12, Vol.51, p.116509-116509, Article 116509

2021

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Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment

Current pharmaceutical design, 2016-01, Vol.22 (42), p.6459-6468

2016

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Regioselective N/C-Heterocyclization of Allenylindium Bromide Across Aryl Azides: One-Pot Synthesis of 5-Methyl-1,2,3-triazoles

Synlett, 2014-06, Vol.25 (13), p.1859-1862

2014

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Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain

Expert opinion on investigational drugs, 2014-02, Vol.23 (2), p.227-241

2014

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Synthesis of Best-Seller Drugs

The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases

Cyclic Opioid Peptides

Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction

Peptidomimetics, a synthetic tool of drug discovery

Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

MC4R biased signalling and the conformational basis of biological function selections

Synthesis of Essential Drugs

Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors

Designing peptide receptor agonists and antagonists

Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH 2 Lead to Potent and Selective Agonists at hMC1R and hMC4R

Design of cyclized selective melanotropins

Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice

Ψ and χ Angle Constrains at the C‑Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His‑d‑Phe-Arg-Trp-NH2 Lead to Potent and Selective Agonists at hMC1R and hMC4R

Cancer vaccine adjuvants - recent clinical progress and future perspectives

Design of Peptide and Peptidomimetic Ligands with Novel Pharmacological Activity Profiles

Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions

Development of N -Acetylated Dipalmitoyl- S -Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists

Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics

Cu(I)–Pd(II)-Catalyzed Cycloaddition–Fusion of 1-Iodoalkynes and Azides: One-Pot Synthesis of Fused Tricyclic Heterosystems

Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice

C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters

Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment

Regioselective N/C-Heterocyclization of Allenylindium Bromide Across Aryl Azides: One-Pot Synthesis of 5-Methyl-1,2,3-triazoles

Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain

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