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Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577

Organic process research & development, 2018-06, Vol.22 (6), p.681-696

2018

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Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights

Journal of organic chemistry, 2003-12, Vol.68 (26), p.9964-9970

2003

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Syntheses of the opioid substructures 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine

Tetrahedron letters, 2011-03, Vol.52 (9), p.953-954

2011

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In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.2974-2979

2005

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3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.4889-4897

2005

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Evaluation of Kilogram-Scale Sonagashira, Suzuki, and Heck Coupling Routes to Oncology Candidate CP-724,714

Organic process research & development, 2005-07, Vol.9 (4), p.440-450

2005

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Convenient preparation of N-substituted indoles by modified Leimgruber-Batcho indole synthesis

Tetrahedron letters, 1996-08, Vol.37 (34), p.6045-6048

1996

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Enantioselective Synthesis of Nicotinic Receptor Probe 7,8-Difluoro-1,2,3,4,5,6- hexahydro-1,5-methano-3-benzazocine

Organic letters, 2006-12, Vol.8 (26), p.5947-5950

2006

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Pinnick Oxidation on Scale: Process Development of a BDK Inhibitor

Organic process research & development, 2024-07, Vol.28 (7), p.2935-2944

2024

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Early Process Development of PF-07054894, a Squaramide-Based Antagonist of C–C Chemokine Receptor Type 6 (CCR6)

Organic process research & development, 2024-06, Vol.28 (6), p.2247-2259

2024

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Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture

Organic process research & development, 2023-05, Vol.27 (5), p.866-874

2023

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Boron Trichloride/Tetra-n-Butylammonium Iodide: A Mild, Selective Combination Reagent for the Cleavage of Primary Alkyl Aryl Ethers

Journal of organic chemistry, 1999-12, Vol.64 (26), p.9719-9721

1999

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Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Journal of medicinal chemistry, 2005-05, Vol.48 (10), p.3474-3477

2005

Volltextzugriff (PDF)

Synthesis of 2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepine via Oxidative Cleavage and Reductive Amination Strategies

Synthesis (Stuttgart), 2004-08, Vol.2004 (11), p.1755-1758

2004

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Low efficacy partial agonists of the α4β2 nicotinic acetylcholine receptor (nAChR). Does functional efficacy govern in vivo response?

Biochemical pharmacology, 2009-10, Vol.78 (7), p.919-919

2009

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A mild method for the conversion of activated aryl methyl groups to carboxaldehydes via the uncatalyzed periodate cleavage of enamines

Tetrahedron letters, 1994-01, Vol.35 (2), p.219-222

1994

Volltextzugriff (PDF)

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

Journal of medicinal chemistry, 2005-05, Vol.48 (10), p.3474-3477

2005

Volltextzugriff (PDF)

3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.4889-4897

2005

Volltextzugriff (PDF)

In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.2974-2979

2005

Volltextzugriff (PDF)

Indenes via fulvene intermediates

Tetrahedron letters, 1994-09, Vol.35 (36), p.6627-6630

1994

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Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights

ChemInform, 2004-05, Vol.35 (21), p.no-no

2004

Volltextzugriff (PDF)

Detection of organic chemicals by SAW sensor array

Sensors and actuators. B, Chemical, 1999-07, Vol.56 (1), p.155-157

1999

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Electrochemical piezoelectric sensors for trace ionic contaminants

IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 1998-09, Vol.45 (5), p.1408-1415

1998

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Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577

Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights

Syntheses of the opioid substructures 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine

In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine

3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

Evaluation of Kilogram-Scale Sonagashira, Suzuki, and Heck Coupling Routes to Oncology Candidate CP-724,714

Convenient preparation of N-substituted indoles by modified Leimgruber-Batcho indole synthesis

Enantioselective Synthesis of Nicotinic Receptor Probe 7,8-Difluoro-1,2,3,4,5,6- hexahydro-1,5-methano-3-benzazocine

Pinnick Oxidation on Scale: Process Development of a BDK Inhibitor

Early Process Development of PF-07054894, a Squaramide-Based Antagonist of C–C Chemokine Receptor Type 6 (CCR6)

Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture

Boron Trichloride/Tetra-n-Butylammonium Iodide: A Mild, Selective Combination Reagent for the Cleavage of Primary Alkyl Aryl Ethers

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Synthesis of 2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepine via Oxidative Cleavage and Reductive Amination Strategies

Low efficacy partial agonists of the α4β2 nicotinic acetylcholine receptor (nAChR). Does functional efficacy govern in vivo response?

A mild method for the conversion of activated aryl methyl groups to carboxaldehydes via the uncatalyzed periodate cleavage of enamines

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation

In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine

Indenes via fulvene intermediates

Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights

Detection of organic chemicals by SAW sensor array

Electrochemical piezoelectric sensors for trace ionic contaminants

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