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Digital twin of a continuous direct compression line for drug product and process design using a hybrid flowsheet modelling approach

International journal of pharmaceutics, 2022-11, Vol.628, p.122336-122336, Article 122336

2022

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Development of a predictive model for gravimetric powder feeding from an API-rich materials properties library

International journal of pharmaceutics, 2022-09, Vol.625, p.122071-122071, Article 122071

2022

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Continuous Mixing Technology: Characterization of a Vertical Mixer Using Residence Time Distribution

Journal of pharmaceutical sciences, 2021-07, Vol.110 (7), p.2694-2702

2021

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Towards Integrated Drug Substance and Drug Product Design for an Active Pharmaceutical Ingredient Using Particle Engineering

AAPS PharmSciTech, 2011-03, Vol.12 (1), p.287-294

2011

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Total Synthesis and Determination of the Absolute Configuration of Epibatidine

Journal of organic chemistry, 1994-04, Vol.59 (7), p.1771-1778

1994

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Crystallisation induced resolution of 4-fluorophenylglycine

Tetrahedron: asymmetry, 1996-12, Vol.7 (12), p.3351-3352

1996

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Analytical and Preparative Enantiomeric Separation of a Series of C5-Cycloalkylamine-L,4-Benzodiazepin-2-one CCK B Receptor Antagonists by Chiral HPLC

Journal of liquid chromatography & related technologies, 1997-01, Vol.20 (1), p.111-121

1997

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Analytical and Preparative Enantiomeric Separation of a Series of C5-Cycloalkylamine-L,4-Benzodiazepin-2-one CCKB Receptor Antagonists by Chiral HPLC

Journal of liquid chromatography & related technologies, 1997-01, Vol.20 (1), p.111-121

1997

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Resolution of Synthetic (+)- and (-)-Epibatidine by Chiral High Performance Liquid Chromatography and Identification of the Natural Enantiomer

Journal of liquid chromatography, 1994-03, Vol.17 (6), p.1257-1264

1994

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Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved Pharmacokinetic Profiles

Journal of medicinal chemistry, 1999-06, Vol.42 (12), p.2087-2104

1999

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Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route

Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6691-6696

2007

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Axially chiral 1,1′-binaphthyls with non-identical groups in 2,2′-positions. Synthesis of the enantiomerically pure 2-hydroxy-2′-thiol and substituted 2-amino-2′-thiols

Tetrahedron: asymmetry, 1997-02, Vol.8 (4), p.537-546

1997

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The SN2 Reaction in the Solid State. An Unusual, BAl2 Aminolysis of an Ester Group in Crystalline (±)-2-Amino-2‘-hydroxy-3‘-(methoxycarbonyl)- 1,1‘-binaphthyl Elucidated by X-ray Diffraction and Isotopic Labeling. New Experimental Evidence for Linearity in SN2 Substitution

Journal of the American Chemical Society, 1996-01, Vol.118 (2), p.487-488

1996

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Clonidine improves perioperative myocardial ischemia, reduces anesthetic requirement, and alters hemodynamic parameters in patients undergoing coronary artery bypass surgery

Journal of cardiothoracic and vascular anesthesia, 1993-08, Vol.7 (4), p.386-395

1993

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An Efficient Protocol for the Preparation of Primary Alcohols Bearing a β-Chiral Center via an Oxazolidinone Auxiliary Mediated Resolution, and Application to the Synthesis of 4,4-Disubstituted Piperidine Substance P Antagonists

Journal of organic chemistry, 2000-04, Vol.65 (8), p.2615-2618

2000

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Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT 1D Receptor Ligands with Improved Pharmacokinetic Profiles

Journal of medicinal chemistry, 1999-06, Vol.42 (12), p.2087-2104

1999

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The S N 2 Reaction in the Solid State. An Unusual, B Al 2 Aminolysis of an Ester Group in Crystalline (±)-2-Amino-2‘-hydroxy-3‘-(methoxycarbonyl)- 1,1‘-binaphthyl Elucidated by X-ray Diffraction and Isotopic Labeling. New Experimental Evidence for Linearity in S N 2 Substitution

Journal of the American Chemical Society, 1996-01, Vol.118 (2), p.487-488

1996

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Digital twin of a continuous direct compression line for drug product and process design using a hybrid flowsheet modelling approach

Development of a predictive model for gravimetric powder feeding from an API-rich materials properties library

Continuous Mixing Technology: Characterization of a Vertical Mixer Using Residence Time Distribution

Towards Integrated Drug Substance and Drug Product Design for an Active Pharmaceutical Ingredient Using Particle Engineering

Total Synthesis and Determination of the Absolute Configuration of Epibatidine

Crystallisation induced resolution of 4-fluorophenylglycine

Analytical and Preparative Enantiomeric Separation of a Series of C5-Cycloalkylamine-L,4-Benzodiazepin-2-one CCK B Receptor Antagonists by Chiral HPLC

Analytical and Preparative Enantiomeric Separation of a Series of C5-Cycloalkylamine-L,4-Benzodiazepin-2-one CCKB Receptor Antagonists by Chiral HPLC

Resolution of Synthetic (+)- and (-)-Epibatidine by Chiral High Performance Liquid Chromatography and Identification of the Natural Enantiomer

Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved Pharmacokinetic Profiles

Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route

Axially chiral 1,1′-binaphthyls with non-identical groups in 2,2′-positions. Synthesis of the enantiomerically pure 2-hydroxy-2′-thiol and substituted 2-amino-2′-thiols

The SN2 Reaction in the Solid State. An Unusual, BAl2 Aminolysis of an Ester Group in Crystalline (±)-2-Amino-2‘-hydroxy-3‘-(methoxycarbonyl)- 1,1‘-binaphthyl Elucidated by X-ray Diffraction and Isotopic Labeling. New Experimental Evidence for Linearity in SN2 Substitution

Clonidine improves perioperative myocardial ischemia, reduces anesthetic requirement, and alters hemodynamic parameters in patients undergoing coronary artery bypass surgery

An Efficient Protocol for the Preparation of Primary Alcohols Bearing a β-Chiral Center via an Oxazolidinone Auxiliary Mediated Resolution, and Application to the Synthesis of 4,4-Disubstituted Piperidine Substance P Antagonists

Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT 1D Receptor Ligands with Improved Pharmacokinetic Profiles

The S N 2 Reaction in the Solid State. An Unusual, B Al 2 Aminolysis of an Ester Group in Crystalline (±)-2-Amino-2‘-hydroxy-3‘-(methoxycarbonyl)- 1,1‘-binaphthyl Elucidated by X-ray Diffraction and Isotopic Labeling. New Experimental Evidence for Linearity in S N 2 Substitution

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