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Stapled Peptides for Intracellular Drug Targets

Methods in Enzymology, 2012, Vol.503, p.3-33

2012

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Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

Nature protocols, 2011-06, Vol.6 (6), p.761-771

2011

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Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

Nature biotechnology, 2017-09, Vol.35 (9), p.845-851

2017

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The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members

Clinical cancer research, 2007-12, Vol.13 (24), p.7264-7270

2007

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Synthesis of all-hydrocarbon stapled [alpha]-helical peptides by ring-closing olefin metathesis

Nature protocols, 2011-06, Vol.6 (6), p.761

2011

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Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

Nature biotechnology, 2016-07, Vol.34 (7), p.738-745

2016

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Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (44), p.17942-17947

2012

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Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase

The Journal of biological chemistry, 2017-03, Vol.292 (12), p.5007-5017

2017

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Direct inhibition of the NOTCH transcription factor complex

Nature (London), 2009-11, Vol.462 (7270), p.182-188

2009

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Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide

Journal of the American Chemical Society, 2007-03, Vol.129 (9), p.2456-2457

2007

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Nonspecifically bound proteins spin while diffusing along DNA

Nature structural & molecular biology, 2009-12, Vol.16 (12), p.1224-1229

2009

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Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (44), p.18497-18502

2009

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The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase

Nature communications, 2020-09, Vol.11 (1), p.4437-4437, Article 4437

2020

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Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA

Nature (London), 2005-03, Vol.434 (7033), p.612-618

2005

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Regulation of MLL1 H3K4 methyltransferase activity by its core components

Nature structural & molecular biology, 2006-08, Vol.13 (8), p.713-719

2006

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Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

Nature communications, 2017-09, Vol.8 (1), p.660-11, Article 660

2017

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A Base-Excision DNA-Repair Protein Finds Intrahelical Lesion Bases by Fast Sliding in Contact with DNA

Proceedings of the National Academy of Sciences - PNAS, 2006-04, Vol.103 (15), p.5752-5757

2006

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Structure of the Stapled p53 Peptide Bound to Mdm2

Journal of the American Chemical Society, 2012-01, Vol.134 (1), p.103-106

2012

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Recognition and reprogramming of E3 ubiquitin ligase surfaces by α-helical peptides

Nature communications, 2023-11, Vol.14 (1), p.6992-19, Article 6992

2023

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Targeted β‐catenin ubiquitination and degradation by multifunctional stapled peptides

Journal of peptide science, 2022-07, Vol.28 (7), p.e3389-n/a

2022

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Mirror-image ligand discovery enabled by single-shot fast-flow synthesis of D-proteins

Nature communications, 2024-02, Vol.15 (1), p.1813-1813, Article 1813

2024

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Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix

Science (American Association for the Advancement of Science), 2004-09, Vol.305 (5689), p.1466-1470

2004

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IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex

Cell reports (Cambridge), 2017-01, Vol.18 (2), p.432-442

2017

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Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme

Nature (London), 2009-12, Vol.462 (7274), p.762-766

2009

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Stitched α‑Helical Peptides via Bis Ring-Closing Metathesis

Journal of the American Chemical Society, 2014-09, Vol.136 (35), p.12314-12322

2014

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Stapled Peptides for Intracellular Drug Targets

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members

Synthesis of all-hydrocarbon stapled [alpha]-helical peptides by ring-closing olefin metathesis

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase

Direct inhibition of the NOTCH transcription factor complex

Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide

Nonspecifically bound proteins spin while diffusing along DNA

Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase

The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase

Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA

Regulation of MLL1 H3K4 methyltransferase activity by its core components

Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

A Base-Excision DNA-Repair Protein Finds Intrahelical Lesion Bases by Fast Sliding in Contact with DNA

Structure of the Stapled p53 Peptide Bound to Mdm2

Recognition and reprogramming of E3 ubiquitin ligase surfaces by α-helical peptides

Targeted β‐catenin ubiquitination and degradation by multifunctional stapled peptides

Mirror-image ligand discovery enabled by single-shot fast-flow synthesis of D-proteins

Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix

IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex

Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme

Stitched α‑Helical Peptides via Bis Ring-Closing Metathesis

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