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Abstract IA-007: Exploiting DNA repair defects in head and neck squamous cell carcinoma

Clinical cancer research, 2021-04, Vol.27 (8_Supplement), p.IA-007-IA-007

Vens, Conchita

2021

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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells

The Journal of experimental medicine, 2014-08, Vol.211 (9), p.1759-1777

2014

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Improved pharmacodynamic (PD) assessment of low dose PARP inhibitor PD activity for radiotherapy and chemotherapy combination trials

Radiotherapy and oncology, 2018-03, Vol.126 (3), p.443-449

2018

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DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity

Oncotarget, 2018-08, Vol.9 (60), p.31719-31743

2018

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Phase I feasibility study of Olaparib in combination with loco-regional radiotherapy in head and neck squamous cell carcinoma

Clinical and translational radiation oncology, 2024-01, Vol.44, p.100698-100698, Article 100698

2024

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Biological Determinants of Chemo-Radiotherapy Response in HPV-Negative Head and Neck Cancer: A Multicentric External Validation

Frontiers in oncology, 2020-01, Vol.9, p.1470-1470

2020

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Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association

PloS one, 2018-11, Vol.13 (11), p.e0206632

2018

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Targeting Base Excision Repair as a Sensitization Strategy in Radiotherapy

Seminars in radiation oncology, 2010-10, Vol.20 (4), p.241-249

2010

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Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2)

Drug metabolism and disposition, 2008-04, Vol.36 (4), p.631-640

2008

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Strategies to improve radiotherapy with targeted drugs

Nature reviews. Cancer, 2011-04, Vol.11 (4), p.239-253

2011

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Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status

International journal of radiation oncology, biology, physics, 2006-02, Vol.64 (2), p.562-572

2006

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Mechanism of cell killing after ionizing radiation by a dominant negative DNA polymerase beta

DNA repair, 2009-03, Vol.8 (3), p.336-346

2009

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Ionizing Radiation Sensitivity of DNA Polymerase Lambda-Deficient Cells

Radiation research, 2007-12, Vol.168 (6), p.683-688

2007

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Involvement of DNA Polymerase Beta in Repair of Ionizing Radiation Damage as Measured by In Vitro Plasmid Assays

Radiation research, 2007-09, Vol.168 (3), p.281-291

2007

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Novel therapeutics in combination with radiotherapy to improve cancer treatment: Rationale, mechanisms of action and clinical perspective

Drug resistance updates, 2010-02, Vol.13 (1), p.29-43

2010

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Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non-Small Cell Lung Cancer

Clinical cancer research, 2021-03, Vol.27 (5), p.1256-1266

2021

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HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β

Nature communications, 2014-11, Vol.5 (1), p.5513-5513, Article 5513

2014

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Abstract C009: Clinical pharmacokinetic and pharmacodynamic analyses support biological effectivity of the PARP inhibitor olaparib as radiosensitizer at low doses

Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.C009-C009

2019

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Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development

Molecular cancer therapeutics, 2021-09, Vol.20 (9), p.1614-1626

2021

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Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells

Radiotherapy and oncology, 2015-09, Vol.116 (3), p.358-365

2015

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NAD+ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study

Radiotherapy and oncology, 2014-02, Vol.110 (2), p.348-354

2014

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Disease outcome and associated factors after definitive platinum based chemoradiotherapy for advanced stage HPV-negative head and neck cancer

Radiotherapy and oncology, 2022-10, Vol.175, p.112-121

2022

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Drug Sensitivity Prediction Models Reveal a Link between DNA Repair Defects and Poor Prognosis in HNSCC

Cancer research (Chicago, Ill.), 2019-11, Vol.79 (21), p.5597-5611

2019

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Abstract IA-007: Exploiting DNA repair defects in head and neck squamous cell carcinoma

Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemo-radiotherapy

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells

Improved pharmacodynamic (PD) assessment of low dose PARP inhibitor PD activity for radiotherapy and chemotherapy combination trials

DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity

Correction: Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemo-radiotherapy

Phase I feasibility study of Olaparib in combination with loco-regional radiotherapy in head and neck squamous cell carcinoma

Biological Determinants of Chemo-Radiotherapy Response in HPV-Negative Head and Neck Cancer: A Multicentric External Validation

Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association

Targeting Base Excision Repair as a Sensitization Strategy in Radiotherapy

Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2)

Strategies to improve radiotherapy with targeted drugs

Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status

Mechanism of cell killing after ionizing radiation by a dominant negative DNA polymerase beta

Ionizing Radiation Sensitivity of DNA Polymerase Lambda-Deficient Cells

Involvement of DNA Polymerase Beta in Repair of Ionizing Radiation Damage as Measured by In Vitro Plasmid Assays

Novel therapeutics in combination with radiotherapy to improve cancer treatment: Rationale, mechanisms of action and clinical perspective

Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non-Small Cell Lung Cancer

HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β

Abstract C009: Clinical pharmacokinetic and pharmacodynamic analyses support biological effectivity of the PARP inhibitor olaparib as radiosensitizer at low doses

Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development

Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells

NAD+ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study

Disease outcome and associated factors after definitive platinum based chemoradiotherapy for advanced stage HPV-negative head and neck cancer

Drug Sensitivity Prediction Models Reveal a Link between DNA Repair Defects and Poor Prognosis in HNSCC

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