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Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors

Bioorganic & medicinal chemistry letters, 2020-04, Vol.30 (8), p.127060, Article 127060

2020

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Gene Expression Profiling of Gliadin Effects on Intestinal Epithelial Cells Suggests Novel Non-Enzymatic Functions of Pepsin and Trypsin

PloS one, 2013-06, Vol.8 (6), p.e66307-e66307

2013

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Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics

Drug metabolism and disposition, 2011-03, Vol.39 (3), p.412-418

2011

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Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors

Biochemical pharmacology, 2006-02, Vol.71 (5), p.683-692

2006

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A Cyclopent-2-enecarbonyl Group Mimics Proline at the P2 Position of Prolyl Oligopeptidase Inhibitors

Journal of medicinal chemistry, 2004-11, Vol.47 (23), p.5605-5607

2004

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Beneficial Effect of Prolyl Oligopeptidase Inhibition on Spatial Memory in Young but Not in Old Scopolamine‐Treated Rats

Basic & clinical pharmacology & toxicology, 2007-02, Vol.100 (2), p.132-138

2007

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2( S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2( S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors

Bioorganic & medicinal chemistry, 2007-03, Vol.15 (5), p.2024-2031

2007

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Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters

Journal of comparative neurology (1911), 2008-04, Vol.507 (5), p.1694-1708

2008

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Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues

Histochemistry and cell biology, 2008-11, Vol.130 (5), p.993-1003

2008

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Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site

Biochemical journal, 2004-09, Vol.382 (Pt 3), p.1003-1008

2004

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Synthesis and Characterization of the Novel Fluorescent Prolyl Oligopeptidase Inhibitor 4-Fluoresceinthiocarbamoyl- 6-aminocaproyl-l-prolyl-2(S)-(Hydroxy- acetyl)pyrrolidine

Journal of medicinal chemistry, 2005-11, Vol.48 (23), p.7093-7095

2005

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Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819

Biochemical pharmacology, 2002-08, Vol.64 (3), p.463-471

2002

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Distribution of immunoreactive prolyl oligopeptidase in human and rat brain

Neurochemical research, 2007-08, Vol.32 (8), p.1365-1374

2007

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Evolutionary relationships of the prolyl oligopeptidase family enzymes

European journal of biochemistry, 2004-07, Vol.271 (13), p.2705-2715

2004

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Characterization of membrane-bound prolyl endopeptidase from brain

The FEBS journal, 2008-09, Vol.275 (17), p.4415-4427

2008

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Dicarboxylic Acid Azacycle l-Prolyl-pyrrolidine Amides as Prolyl Oligopeptidase Inhibitors and Three-Dimensional Quantitative Structure−Activity Relationship of the Enzyme−Inhibitor Interactions

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.4772-4782

2005

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Enzymatic detoxification of gluten by germinating wheat proteases: Implications for new treatment of celiac disease

Annals of medicine (Helsinki), 2009, Vol.41 (5), p.390-400

2009

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Dicarboxylic Acid bis(l-Prolyl-pyrrolidine) Amides as Prolyl Oligopeptidase Inhibitors

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4581-4584

2002

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Prolamin Hydrolysis in Wheat Sourdoughs with Differing Proteolytic Activities

Journal of agricultural and food chemistry, 2007-02, Vol.55 (3), p.978-984

2007

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4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors

Bioorganic & medicinal chemistry, 2002-07, Vol.10 (7), p.2199-2206

2002

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Prolyl Endopeptidase Is Involved in Cellular Signalling in Human Neuroblastoma SH-SY5Y Cells

Neuro-Signals, 2011, Vol.19 (2), p.97-109

2011

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Conformationally rigid N-acyl-5-alkyl- l-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors

Bioorganic & medicinal chemistry, 2003-08, Vol.11 (17), p.3611-3619

2003

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New Prolyl Oligopeptidase Inhibitors Developed from Dicarboxylic Acid Bis(l-prolyl-pyrrolidine) Amides

Journal of medicinal chemistry, 2003-10, Vol.46 (21), p.4543-4551

2003

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Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease

Scandinavian journal of gastroenterology, 2007-01, Vol.42 (5), p.562-571

2007

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An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (21), p.5590-5593

2006

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Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors

Gene Expression Profiling of Gliadin Effects on Intestinal Epithelial Cells Suggests Novel Non-Enzymatic Functions of Pepsin and Trypsin

Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors

A Cyclopent-2-enecarbonyl Group Mimics Proline at the P2 Position of Prolyl Oligopeptidase Inhibitors

Beneficial Effect of Prolyl Oligopeptidase Inhibition on Spatial Memory in Young but Not in Old Scopolamine‐Treated Rats

2( S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2( S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors

Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters

Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues

Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site

Synthesis and Characterization of the Novel Fluorescent Prolyl Oligopeptidase Inhibitor 4-Fluoresceinthiocarbamoyl- 6-aminocaproyl-l-prolyl-2(S)-(Hydroxy- acetyl)pyrrolidine

Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819

Distribution of immunoreactive prolyl oligopeptidase in human and rat brain

Evolutionary relationships of the prolyl oligopeptidase family enzymes

Characterization of membrane-bound prolyl endopeptidase from brain

Dicarboxylic Acid Azacycle l-Prolyl-pyrrolidine Amides as Prolyl Oligopeptidase Inhibitors and Three-Dimensional Quantitative Structure−Activity Relationship of the Enzyme−Inhibitor Interactions

Enzymatic detoxification of gluten by germinating wheat proteases: Implications for new treatment of celiac disease

Dicarboxylic Acid bis(l-Prolyl-pyrrolidine) Amides as Prolyl Oligopeptidase Inhibitors

Prolamin Hydrolysis in Wheat Sourdoughs with Differing Proteolytic Activities

4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors

Prolyl Endopeptidase Is Involved in Cellular Signalling in Human Neuroblastoma SH-SY5Y Cells

Conformationally rigid N-acyl-5-alkyl- l-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors

New Prolyl Oligopeptidase Inhibitors Developed from Dicarboxylic Acid Bis(l-prolyl-pyrrolidine) Amides

Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease

An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors

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