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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

PloS one, 2018-11, Vol.13 (11), p.e0206279-e0206279

2018

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A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1616-1620

2014

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A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry

Rapid communications in mass spectrometry, 2015-11, Vol.29 (22), p.2175-2183

2015

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Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model

PloS one, 2012-04, Vol.7 (4), p.e34822

2012

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In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

Drug metabolism and disposition, 2003-08, Vol.31 (8), p.1005-1015

2003

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Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.243-253

2005

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Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects

Drug metabolism and disposition, 2013-02, Vol.41 (2), p.445-456

2013

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Epoxidation of Olefins by Cytochrome P450: Evidence from Site-Specific Mutagenesis for Hydroperoxo-Iron as an Electrophilic Oxidant

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (7), p.3555-3560

1998

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Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor, in humans

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2185-2198

2008

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Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Drug metabolism and disposition, 2012-03, Vol.40 (3), p.625-634

2012

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Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

Journal of the American Chemical Society, 2000-03, Vol.122 (12), p.2677-2686

2000

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IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

Drug metabolism and disposition, 2003-10, Vol.31 (10), p.1240-1250

2003

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A rapid and specific derivatization procedure to identify acyl-glucuronides by mass spectrometry

Rapid communications in mass spectrometry, 2010-07, Vol.24 (14), p.2109-2121

2010

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Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections

Journal of medicinal chemistry, 2009-12, Vol.52 (23), p.7446-7457

2009

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Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4

Proceedings of the National Academy of Sciences - PNAS, 1996-05, Vol.93 (10), p.4644-4648

1996

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On the Mechanism of Action of Cytochrome P450: Evaluation of Hydrogen Abstraction in Oxygen-Dependent Alcohol Oxidation

Biochemistry (Easton), 1994-05, Vol.33 (21), p.6442-6449

1994

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The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Rapid communications in mass spectrometry, 2010-07, Vol.24 (14), p.2151-2161

2010

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Discrete Species of Activated Oxygen Yield Different Cytochrome P450 Heme Adducts from Aldehydes

Biochemistry (Easton), 1999-08, Vol.38 (32), p.10511-10518

1999

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Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

Journal of the American Chemical Society, 1991-07, Vol.113 (15), p.5886-5887

1991

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Metabolism and disposition of a gamma-aminobutyric acid type A receptor partial agonist in humans

Drug metabolism and disposition, 2008-04, Vol.36 (4), p.655-662

2008

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Old yellow enzyme: Aromatization of cyclic enones and the mechanism of a novel dismutation reaction

Biochemistry (Easton), 1995-04, Vol.34 (13), p.4246-4256

1995

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Aromatization of a Bicyclic Steroid Analog, 3-Oxodecalin-4-ene-10-carboxaldehyde, by Liver Microsomal Cytochrome P450 2B4

Biochemistry (Easton), 1994-11, Vol.33 (46), p.13651-13661

1994

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Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

Journal of the American Chemical Society, 1998-09, Vol.120 (37), p.9718-9719

1998

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Mechanism-Based Inactivation of Cytochrome P450 2B4 by Aldehydes: Relationship to Aldehyde Deformylation via a Peroxyhemiacetal Intermediate

Biochemistry (Easton), 1997-04, Vol.36 (16), p.4895-4902

1997

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A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes

Rapid communications in mass spectrometry, 2015-11, Vol.29 (22), p.2175-2183

2015

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry

Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model

In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects

Epoxidation of Olefins by Cytochrome P450: Evidence from Site-Specific Mutagenesis for Hydroperoxo-Iron as an Electrophilic Oxidant

Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor, in humans

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

A rapid and specific derivatization procedure to identify acyl-glucuronides by mass spectrometry

Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections

Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4

On the Mechanism of Action of Cytochrome P450: Evaluation of Hydrogen Abstraction in Oxygen-Dependent Alcohol Oxidation

The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Discrete Species of Activated Oxygen Yield Different Cytochrome P450 Heme Adducts from Aldehydes

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

Metabolism and disposition of a gamma-aminobutyric acid type A receptor partial agonist in humans

Old yellow enzyme: Aromatization of cyclic enones and the mechanism of a novel dismutation reaction

Aromatization of a Bicyclic Steroid Analog, 3-Oxodecalin-4-ene-10-carboxaldehyde, by Liver Microsomal Cytochrome P450 2B4

Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

Mechanism-Based Inactivation of Cytochrome P450 2B4 by Aldehydes: Relationship to Aldehyde Deformylation via a Peroxyhemiacetal Intermediate

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes

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