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Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivo

British journal of clinical pharmacology, 2016-09, Vol.82 (3), p.673-682

Vauquelin, Georges

2016

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Distinct in vivo target occupancy by bivalent‐ and induced‐fit‐like binding drugs

British journal of pharmacology, 2017-12, Vol.174 (23), p.4233-4246

Vauquelin, Georges

2017

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Oscillatory behaviour in an emptying–filling box

Journal of fluid mechanics, 2015-10, Vol.781, p.712-726

Vauquelin, O.

2015

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On the 'micro'-pharmacodynamic and pharmacokinetic mechanisms that contribute to long-lasting drug action

Expert opinion on drug discovery, 2015-10, Vol.10 (10), p.1085-1098

Vauquelin, Georges

2015

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Link between a high k on for drug binding and a fast clinical action: to be or not to be?

MedChemComm, 2018-09, Vol.9 (9), p.1426-1438

Vauquelin, Georges

2018

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Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

British journal of pharmacology, 2013-04, Vol.168 (8), p.1771-1785

2013

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Link between a high kon for drug binding and a fast clinical action: to be or not to be?

MedChemComm, 2018-01, Vol.9 (9), p.1426-1438

Vauquelin, Georges

2018

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Competition in drug binding and … the race to equilibrium

Fundamental & clinical pharmacology, 2023-02, Vol.37 (1), p.147-157

2023

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Effects of target binding kinetics on in vivo drug efficacy: k off , k on and rebinding

British journal of pharmacology, 2016-08, Vol.173 (15), p.2319-2334

Vauquelin, Georges

2016

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Effects of target binding kinetics on in vivo drug efficacy: koff, kon and rebinding

British journal of pharmacology, 2016-08, Vol.173 (15), p.2319-2334

Vauquelin, Georges

2016

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Long‐lasting target binding and rebinding as mechanisms to prolong in vivo drug action

British journal of pharmacology, 2010-10, Vol.161 (3), p.488-508

2010

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Simplified models for heterobivalent ligand binding: when are they applicable and which are the factors that affect their target residence time

Naunyn-Schmiedeberg's archives of pharmacology, 2013-11, Vol.386 (11), p.949-962

Vauquelin, Georges

2013

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Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time

Expert opinion on drug discovery, 2010-10, Vol.5 (10), p.927-941

Vauquelin, Georges

2010

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Maladie cœliaque

La revue de medecine interne, 2023-10, Vol.44 (10), p.539-545

2023

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Link between a high kon for drug binding and a fast clinical action: to be or not to be?Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00296g

MedChemComm, 2018-09, Vol.9 (9), p.1426-1438

Vauquelin, Georges

2018

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Sartan-AT1 receptor interactions: in vitro evidence for insurmountable antagonism and inverse agonism

Molecular and cellular endocrinology, 2009-04, Vol.302 (2), p.237-243

2009

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Experimental simulations of fire-induced smoke control in tunnels using an “air–helium reduced scale model”: Principle, limitations, results and future

Tunnelling and underground space technology, 2008-03, Vol.23 (2), p.171-178

Vauquelin, Olivier

2008

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Celiac disease

La revue de medecine interne, 2023-10, Vol.44 (10), p.539-545

2023

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Au Neubourg, un cinéma « Art déco» restauré à l’identique

Études Normandes, 2020, Vol.16 (1), p.49

Vauquelin, Isabelle

2020

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Distinct In Vitro Binding Profile of the Somatostatin Receptor Subtype 2 Antagonist [ 177 Lu]Lu-OPS201 Compared to the Agonist [ 177 Lu]Lu-DOTA-TATE

Pharmaceuticals (Basel, Switzerland), 2021-12, Vol.14 (12), p.1265

2021

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Ligands, their receptors and … plasma membranes

Molecular and cellular endocrinology, 2009-11, Vol.311 (1), p.1-10

2009

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Characterization of bubbles dynamics in aperiodic formation

International journal of heat and mass transfer, 2021-12, Vol.180, p.121646, Article 121646

2021

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Study of Woad ( Isatis tinctoria L.)-Extracted Indoxyl Precursors Conversion into Dyes: Influence of the Oxidative Media on Indigo Recovery Yields and Indigotin/Indirubin Ratio Measured by HPLC-DAD Method

Molecules (Basel, Switzerland), 2024-10, Vol.29 (20), p.4804

2024

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Burning rate of elevated pool fire in a well-ventilated compartment: Effects of radiative heat fluxes

Fire safety journal, 2023-12, Vol.141, p.103933, Article 103933

2023

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Determination of drug-receptor residence times by radioligand binding and functional assays: experimental strategies and physiological relevance

MedChemComm, 2012, Vol.3 (6), p.645-651

Vauquelin, Georges

2012

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Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivo

Distinct in vivo target occupancy by bivalent‐ and induced‐fit‐like binding drugs

Oscillatory behaviour in an emptying–filling box

On the 'micro'-pharmacodynamic and pharmacokinetic mechanisms that contribute to long-lasting drug action

Link between a high k on for drug binding and a fast clinical action: to be or not to be?

Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

Link between a high kon for drug binding and a fast clinical action: to be or not to be?

Competition in drug binding and … the race to equilibrium

Effects of target binding kinetics on in vivo drug efficacy: k off , k on and rebinding

Effects of target binding kinetics on in vivo drug efficacy: koff, kon and rebinding

Long‐lasting target binding and rebinding as mechanisms to prolong in vivo drug action

Simplified models for heterobivalent ligand binding: when are they applicable and which are the factors that affect their target residence time

Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time

Maladie cœliaque

Link between a high kon for drug binding and a fast clinical action: to be or not to be?Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00296g

Sartan-AT1 receptor interactions: in vitro evidence for insurmountable antagonism and inverse agonism

Experimental simulations of fire-induced smoke control in tunnels using an “air–helium reduced scale model”: Principle, limitations, results and future

Celiac disease

Au Neubourg, un cinéma « Art déco» restauré à l’identique

Distinct In Vitro Binding Profile of the Somatostatin Receptor Subtype 2 Antagonist [ 177 Lu]Lu-OPS201 Compared to the Agonist [ 177 Lu]Lu-DOTA-TATE

Ligands, their receptors and … plasma membranes

Characterization of bubbles dynamics in aperiodic formation

Study of Woad ( Isatis tinctoria L.)-Extracted Indoxyl Precursors Conversion into Dyes: Influence of the Oxidative Media on Indigo Recovery Yields and Indigotin/Indirubin Ratio Measured by HPLC-DAD Method

Burning rate of elevated pool fire in a well-ventilated compartment: Effects of radiative heat fluxes

Determination of drug-receptor residence times by radioligand binding and functional assays: experimental strategies and physiological relevance

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