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Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases

Biochemical pharmacology, 2006-11, Vol.72 (10), p.1197-1206

2006

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CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family

The Journal of biological chemistry, 2001-07, Vol.276 (27), p.25302-25308

2001

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CEP‐1347/KT‐7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aβ‐induced cortical neuron apoptosis

Journal of neurochemistry, 2001-05, Vol.77 (3), p.849-863

2001

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Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

Epilepsia (Copenhagen), 1994-03, Vol.35 (2), p.450-460

1994

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Neurotrophic 3,9-Bis[(alkylthio)methyl]- and -Bis(alkoxymethyl)-K-252a Derivatives

Journal of medicinal chemistry, 1997-06, Vol.40 (12), p.1863-1869

1997

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Insulin-like Growth Factor-I: Potential for Treatment of Motor Neuronal Disorders

Experimental neurology, 1993-11, Vol.124 (1), p.73-88

1993

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Insulin-like growth factor-I prevents development of a vincristine neuropathy in mice

Brain research, 1997-11, Vol.774 (1), p.20-26

1997

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Aroyl(aminoacyl)pyrroles, a New Class of Anticonvulsant Agents

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1578-1584

1997

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Structure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives

Journal of medicinal chemistry, 2003-02, Vol.46 (4), p.652-652

2003

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CEP-1347 increases ChAT activity in culture and promotes cholinergic neurone survival following fimbria-fornix lesion

Neuroreport, 2000-07, Vol.11 (10), p.2271-2276

2000

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Pharmacological Induction of Nerve Growth Factor mRNA in Adult Rat Brain

Experimental neurology, 1993-10, Vol.123 (2), p.295-302

1993

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Pyrroloisoquinoline antidepressants. 3. A focus on serotonin

Journal of medicinal chemistry, 1990-10, Vol.33 (10), p.2793-2797

1990

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Structure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives

Journal of medicinal chemistry, 1998-04, Vol.41 (8), p.1315-1343

1998

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CEP-751 inhibits trk receptor tyrosine kinase activityin vitro and exhibits anti-tumor activity

International journal of cancer, 1997-08, Vol.72 (4), p.673-679

1997

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Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587)

Clinical cancer research, 1998-08, Vol.4 (8), p.1887-1898

1998

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Orally Active Benzamide Antipsychotic Agents with Affinity for Dopamine D2, Serotonin 5-HT1A, and Adrenergic α1 Receptors

Journal of medicinal chemistry, 1998-06, Vol.41 (12), p.1997-2009

1998

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2-Substituted 1-azabicycloalkanes, a new class of non-opiate antinociceptive agents

Journal of medicinal chemistry, 1992-07, Vol.35 (15), p.2855-2863

1992

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A New Arylpiperazine Antipsychotic with High D2/D3/5-HT1A/.alpha.1A-Adrenergic Affinity and a Low Potential for Extrapyramidal Effects

Journal of medicinal chemistry, 1994-04, Vol.37 (8), p.1060-1062

1994

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Deposition of β/A4 Immunoreactivity and Neuronal Pathology in Transgenic Mice Expressing the Carboxyl-Terminal Fragment of the Alzheimer Amyloid Precursor in the Brain

Proceedings of the National Academy of Sciences - PNAS, 1992-11, Vol.89 (22), p.10857-10861

1992

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Differential analgesic cross-tolerance to morphine between lipophilic and hydrophilic narcotic agonists

Life sciences (1973), 1984-01, Vol.34 (1), p.13-21

1984

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CEP‐751 inhibits trk receptor tyrosine kinase activity in vitro and exhibits anti‐tumor activity

International journal of cancer, 1997-08, Vol.72 (4), p.673-679

1997

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A characterization of kyotorphin (Tyr-Arg)-induced antinociception

European journal of pharmacology, 1982-04, Vol.79 (3), p.167-173

1982

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[ 3H][D-Ala 2,NMePhe 4,Gly-ol 5]-enkephalin (mu-opioid) binding in beige-J mice

Peptides (New York, N.Y. : 1980), 1988-05, Vol.9 (3), p.637-642

1988

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Aurintricarboxylic Acid Protects Hippocampal Neurons from NMDA‐and Ischemia‐Induced Toxicity In Vivo

Journal of neurochemistry, 1993-07, Vol.61 (1), p.378-381

1993

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Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases

CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family

CEP‐1347/KT‐7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aβ‐induced cortical neuron apoptosis

Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

Neurotrophic 3,9-Bis[(alkylthio)methyl]- and -Bis(alkoxymethyl)-K-252a Derivatives

Insulin-like Growth Factor-I: Potential for Treatment of Motor Neuronal Disorders

Insulin-like growth factor-I prevents development of a vincristine neuropathy in mice

Aroyl(aminoacyl)pyrroles, a New Class of Anticonvulsant Agents

Structure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives

CEP-1347 increases ChAT activity in culture and promotes cholinergic neurone survival following fimbria-fornix lesion

Pharmacological Induction of Nerve Growth Factor mRNA in Adult Rat Brain

Pyrroloisoquinoline antidepressants. 3. A focus on serotonin

Structure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives

CEP-751 inhibits trk receptor tyrosine kinase activityin vitro and exhibits anti-tumor activity

Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587)

Orally Active Benzamide Antipsychotic Agents with Affinity for Dopamine D2, Serotonin 5-HT1A, and Adrenergic α1 Receptors

2-Substituted 1-azabicycloalkanes, a new class of non-opiate antinociceptive agents

A New Arylpiperazine Antipsychotic with High D2/D3/5-HT1A/.alpha.1A-Adrenergic Affinity and a Low Potential for Extrapyramidal Effects

Deposition of β/A4 Immunoreactivity and Neuronal Pathology in Transgenic Mice Expressing the Carboxyl-Terminal Fragment of the Alzheimer Amyloid Precursor in the Brain

Differential analgesic cross-tolerance to morphine between lipophilic and hydrophilic narcotic agonists

CEP‐751 inhibits trk receptor tyrosine kinase activity in vitro and exhibits anti‐tumor activity

A characterization of kyotorphin (Tyr-Arg)-induced antinociception

[ 3H][D-Ala 2,NMePhe 4,Gly-ol 5]-enkephalin (mu-opioid) binding in beige-J mice

Aurintricarboxylic Acid Protects Hippocampal Neurons from NMDA‐and Ischemia‐Induced Toxicity In Vivo

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