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Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent

Scientific reports, 2020-07, Vol.10 (1), p.12772-13, Article 12772

2020

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Folate–Vinca Alkaloid Conjugates for Cancer Therapy: A Structure–Activity Relationship

Bioconjugate chemistry, 2014-03, Vol.25 (3), p.560-568

2014

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Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate

Bioorganic & medicinal chemistry letters, 2020-04, Vol.30 (7), p.126987-126987, Article 126987

2020

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Detecting Functional and Accessible Folate Receptor Expression in Cancer and Polycystic Kidneys

Molecular pharmaceutics, 2019-09, Vol.16 (9), p.3985-3995

2019

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Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates

Bioconjugate chemistry, 2017-12, Vol.28 (12), p.2921-2931

2017

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Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus

Molecular medicine (Cambridge, Mass.), 2015-07, Vol.21 (1), p.584-596

2015

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Carbohydrate-Based Synthetic Approach to Control Toxicity Profiles of Folate−Drug Conjugates

Journal of organic chemistry, 2010-06, Vol.75 (11), p.3685-3691

2010

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Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis

Clinical immunology (Orlando, Fla.), 2014-01, Vol.150 (1), p.64-77

2014

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Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (4), p.1202-1205

2011

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Intramolecular Chiral Relay at Stereogenic Nitrogen. Synthesis and Application of a New Chiral Auxiliary Derived from (1R,2S)-Norephedrine and Acetone

Journal of organic chemistry, 2004-02, Vol.69 (3), p.714-718

2004

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Abstract 757: Novel warheads for targeted therapies of cancer: The concept and design of oxime-ether-based pro-PBDs

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.757-757

2018

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Abstract 216: pro -Pyrrolobenzodiazepine ( pro -PBD) bioconjugates, the legacy: Design and synthesis of pro -PBD conjugates containing self-immolative substituted disulfide linkers

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.216-216

2019

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Abstract 5147: Novel warheads for targeted therapies of cancer: The concept and design of proPBDs

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5147-5147

2017

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Abstract 4017: Development and application of an immunohistochemistry-based assay for evaluating functional and accessible folate receptor expression in vivo

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4017-4017

2017

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Abstract 4462: Structure-activity relationship studies for PSMA-targeted tubulysin conjugates

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4462-4462

2014

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Abstract 4495: Small molecule approach for targeting tumor-associated macrophages via a functional FRβ

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.4495-4495

2015

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Pictorial Visual Rotation Ability of Engineering Design Graphics Students

Engineering design graphics journal, 2015-12, Vol.79 (1)

2015

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Abstract 4499: Total synthesis of tubulysins: A new chemical reaction leads to analogues with enhanced cytotoxicity

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.4499-4499

2013

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Redesigned High Schools for Transformed STEM Learning: Performance Assessment Pilot Outcome

Journal of STEM education, 2015-10, Vol.16 (4), p.27

2015

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Abstract 2518: Structure-activity relationships of folate-vinca alkaloid conjugates

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.2518-2518

2011

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Abstract 5515: Design and synthesis of releasable folate-drug conjugates possessing optimized carbohydrate-based spacer units

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.5515-5515

2010

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Oxadiazinones as chiral auxiliaries: increased diastereoselectivities in the glycolate aldol reaction of oxadiazinones

Tetrahedron: asymmetry, 2004-11, Vol.15 (21), p.3449-3455

2004

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Synthesis, asymmetric aldol reactions, and x-ray crystallography of some oxadiazinanone derivatives

Journal of heterocyclic chemistry, 2008-09, Vol.45 (5), p.1265-1274

2008

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Effective instructional element utilization in North Carolina technology education programs for students with specific learning disabilities

Ernst, Jeremy Vaughn

2006

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Oxadiazinones as Chiral Auxiliaries: Increased Diastereoselectivities in the Glycolate Aldol Reaction of Oxadiazinones

ChemInform, 2005-03, Vol.36 (12), p.no-no

2005

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Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent

Folate–Vinca Alkaloid Conjugates for Cancer Therapy: A Structure–Activity Relationship

Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate

Detecting Functional and Accessible Folate Receptor Expression in Cancer and Polycystic Kidneys

Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates

Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus

Carbohydrate-Based Synthetic Approach to Control Toxicity Profiles of Folate−Drug Conjugates

Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis

Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation

Intramolecular Chiral Relay at Stereogenic Nitrogen. Synthesis and Application of a New Chiral Auxiliary Derived from (1R,2S)-Norephedrine and Acetone

Abstract 757: Novel warheads for targeted therapies of cancer: The concept and design of oxime-ether-based pro-PBDs

Abstract 216: pro -Pyrrolobenzodiazepine ( pro -PBD) bioconjugates, the legacy: Design and synthesis of pro -PBD conjugates containing self-immolative substituted disulfide linkers

Abstract 5147: Novel warheads for targeted therapies of cancer: The concept and design of proPBDs

Abstract 4017: Development and application of an immunohistochemistry-based assay for evaluating functional and accessible folate receptor expression in vivo

Abstract 4462: Structure-activity relationship studies for PSMA-targeted tubulysin conjugates

Abstract 4495: Small molecule approach for targeting tumor-associated macrophages via a functional FRβ

Pictorial Visual Rotation Ability of Engineering Design Graphics Students

Abstract 4499: Total synthesis of tubulysins: A new chemical reaction leads to analogues with enhanced cytotoxicity

Redesigned High Schools for Transformed STEM Learning: Performance Assessment Pilot Outcome

Abstract 2518: Structure-activity relationships of folate-vinca alkaloid conjugates

Abstract 5515: Design and synthesis of releasable folate-drug conjugates possessing optimized carbohydrate-based spacer units

Oxadiazinones as chiral auxiliaries: increased diastereoselectivities in the glycolate aldol reaction of oxadiazinones

Synthesis, asymmetric aldol reactions, and x-ray crystallography of some oxadiazinanone derivatives

Effective instructional element utilization in North Carolina technology education programs for students with specific learning disabilities

Oxadiazinones as Chiral Auxiliaries: Increased Diastereoselectivities in the Glycolate Aldol Reaction of Oxadiazinones

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