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A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

Cell, 2016-04, Vol.165 (3), p.643-655

2016

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Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma

Cancer research (Chicago, Ill.), 2014-11, Vol.74 (21), p.6364-6374

2014

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Crystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like Activity

Journal of Virology, 2007-11, Vol.81 (22), p.12272-12284

2007

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Mechanism for Coordinated RNA Packaging and Genome Replication by Rotavirus Polymerase VP1

Structure (London), 2008-11, Vol.16 (11), p.1678-1688

2008

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Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression

Pharmaceutics, 2021-12, Vol.13 (12), p.2109

2021

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Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion

PloS one, 2009-06, Vol.4 (6), p.e5766

2009

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Histidine Triad-like Motif of the Rotavirus NSP2 Octamer Mediates both RTPase and NTPase Activities

Journal of molecular biology, 2006-09, Vol.362 (3), p.539-554

2006

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Assembly of a Notch Transcriptional Activation Complex Requires Multimerization

Molecular and Cellular Biology, 2011-04, Vol.31 (7), p.1396-1408

2011

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Role of the Histidine Triad-like Motif in Nucleotide Hydrolysis by the Rotavirus RNA-packaging Protein NSP2

The Journal of biological chemistry, 2004-03, Vol.279 (11), p.10624-10633

2004

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Role of Human DNA Polymerase κ in Extension Opposite from a cis–syn Thymine Dimer

Journal of molecular biology, 2011-04, Vol.408 (2), p.252-261

2011

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Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2)

Bioorganic & medicinal chemistry, 2016-02, Vol.24 (4), p.521-544

2016

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Coupling of Rotavirus Genome Replication and Capsid Assembly

Advances in Virus Research, 2007, Vol.69, p.167-201

2007

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NACK Is an Integral Component of the Notch Transcriptional Activation Complex and Is Critical for Development and Tumorigenesis

Cancer research (Chicago, Ill.), 2014-09, Vol.74 (17), p.4741-4751

2014

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Rotavirus Glycoprotein NSP4 Is a Modulator of Viral Transcription in the Infected Cell

Journal of Virology, 2005-12, Vol.79 (24), p.15165-15174

2005

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Structure-Function Analysis of Rotavirus NSP2 Octamer by Using a Novel Complementation System

Journal of Virology, 2006-08, Vol.80 (16), p.7984-7994

2006

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Replication and transcription of the rotavirus genome

Current pharmaceutical design, 2004-11, Vol.10 (30), p.3769-3777

2004

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A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent

Molecular cell, 2020-07, Vol.79 (1), p.180-190.e4

2020

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Discovery of 8‑Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3‑d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.578-599

2014

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Hierarchical Phosphorylation within the Ankyrin Repeat Domain Defines a Phosphoregulatory Loop That Regulates Notch Transcriptional Activity

The Journal of biological chemistry, 2011-08, Vol.286 (33), p.28844-28857

2011

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Rigosertib Blocks RAS Signaling By Acting As a Small Molecule RAS Mimetic That Binds to the RAS-Binding Domains of RAS Effector Proteins

Blood, 2014-12, Vol.124 (21), p.5616-5616

2014

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Abstract 694: Structure-function analysis of RPL18A, a putative binding target of rigosertib

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.694-694

2015

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Bioinformatic prediction of polymerase elements in the rotavirus VP1 protein

Biological research, 2006, Vol.39 (4), p.649-659

2006

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Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyri d o[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2)

Bioorganic & medicinal chemistry, 2016-02, Vol.24 (4), p.521-544

2016

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Structure of Human DNA Polymerase [kappa] Inserting dATP Opposite an 8-OxoG DNA Lesion

PloS one, 2009-06, Vol.4 (6), p.e5766

2009

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Structure of Human DNA Polymerase Io Inserting dATP Opposite an 8-OxoG DNA Lesion

PloS one, 2009-01, Vol.4 (6), p.e5766-e5766

2009

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A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma

Crystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like Activity

Mechanism for Coordinated RNA Packaging and Genome Replication by Rotavirus Polymerase VP1

Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression

Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion

Histidine Triad-like Motif of the Rotavirus NSP2 Octamer Mediates both RTPase and NTPase Activities

Assembly of a Notch Transcriptional Activation Complex Requires Multimerization

Role of the Histidine Triad-like Motif in Nucleotide Hydrolysis by the Rotavirus RNA-packaging Protein NSP2

Role of Human DNA Polymerase κ in Extension Opposite from a cis–syn Thymine Dimer

Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2)

Coupling of Rotavirus Genome Replication and Capsid Assembly

NACK Is an Integral Component of the Notch Transcriptional Activation Complex and Is Critical for Development and Tumorigenesis

Rotavirus Glycoprotein NSP4 Is a Modulator of Viral Transcription in the Infected Cell

Structure-Function Analysis of Rotavirus NSP2 Octamer by Using a Novel Complementation System

Replication and transcription of the rotavirus genome

A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent

Discovery of 8‑Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3‑d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

Hierarchical Phosphorylation within the Ankyrin Repeat Domain Defines a Phosphoregulatory Loop That Regulates Notch Transcriptional Activity

Rigosertib Blocks RAS Signaling By Acting As a Small Molecule RAS Mimetic That Binds to the RAS-Binding Domains of RAS Effector Proteins

Abstract 694: Structure-function analysis of RPL18A, a putative binding target of rigosertib

Bioinformatic prediction of polymerase elements in the rotavirus VP1 protein

Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyri d o[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2)

Structure of Human DNA Polymerase [kappa] Inserting dATP Opposite an 8-OxoG DNA Lesion

Structure of Human DNA Polymerase Io Inserting dATP Opposite an 8-OxoG DNA Lesion

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