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Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Nature (London), 2014-08, Vol.512 (7512), p.69-73

2014

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GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

The Journal of experimental medicine, 2018-06, Vol.215 (6), p.1519-1529

2018

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FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes

The Journal of immunology (1950), 2014-02, Vol.192 (4), p.1835-1846

2014

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Dietary modulation of the microbiome affects autoinflammatory disease

Nature (London), 2014-12, Vol.516 (7530), p.246-249

2014

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A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Nature communications, 2018-05, Vol.9 (1), p.2036-15, Article 2036

2018

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Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (5), p.1541-1546

2015

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Deregulated inflammasome signaling in disease

Immunological reviews, 2011-09, Vol.243 (1), p.163-173

2011

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Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia

The Journal of immunology (1950), 2010-10, Vol.185 (7), p.4385-4392

2010

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Toxic proteins released from mitochondria in cell death

Oncogene, 2004-04, Vol.23 (16), p.2861-2874

2004

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Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Proceedings of the National Academy of Sciences - PNAS, 2016-12, Vol.113 (50), p.14384-14389

2016

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Therapeutic modulation of inflammasome pathways

Immunological reviews, 2020-09, Vol.297 (1), p.123-138

2020

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Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Scientific reports, 2023-10, Vol.13 (1), p.17992-17992, Article 17992

2023

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The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization

Nature immunology, 2011-10, Vol.12 (10), p.1010-1016

2011

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Comment on: Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3

Rheumatology (Oxford, England), 2023-05, Vol.62 (5), p.e166-e167

2023

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Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface

Immunity (Cambridge, Mass.), 2020-07, Vol.53 (1), p.6-8

2020

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Non-canonical inflammasome activation targets caspase-11

Nature (London), 2011-11, Vol.479 (7371), p.117-121

2011

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IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

Cell, 2009-08, Vol.138 (3), p.562-575

2009

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Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

Nature communications, 2014-02, Vol.5 (1), p.3209-3209, Article 3209

2014

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GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis

EMBO reports, 2022-10, Vol.23 (10), p.e54277-n/a

2022

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Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

The Journal of biological chemistry, 2012-10, Vol.287 (41), p.34474-34483

2012

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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

PLoS biology, 2019-09, Vol.17 (9), p.e3000354-e3000354

2019

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Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

Cell reports (Cambridge), 2017-12, Vol.21 (12), p.3427-3444

2017

Volltextzugriff (PDF)

Pyroptosis

Current biology, 2016-07, Vol.26 (13), p.R568-R572

2016

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Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection

Science advances, 2022-03, Vol.8 (9), p.eabj7293-eabj7293

2022

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Does caspase-12 suppress inflammasome activation?

Nature (London), 2016-06, Vol.534 (7605), p.E1-E4

2016

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Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes

Dietary modulation of the microbiome affects autoinflammatory disease

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

Deregulated inflammasome signaling in disease

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia

Toxic proteins released from mitochondria in cell death

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Therapeutic modulation of inflammasome pathways

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization

Comment on: Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3

Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface

Non-canonical inflammasome activation targets caspase-11

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis

Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

Pyroptosis

Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection

Does caspase-12 suppress inflammasome activation?

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