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RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals

The journal of clinical endocrinology and metabolism, 2015-04, Vol.100 (4), p.1639-1645

2015

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Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia

Atherosclerosis, 2017-09, Vol.264, p.100-107

2017

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Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation

Molecules (Basel, Switzerland), 2019-05, Vol.24 (10), p.1892

2019

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Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment

The journal of clinical endocrinology and metabolism, 2018-07, Vol.103 (7), p.2601-2612

2018

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Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (12), p.E1471-E1479

2015

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Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells

Cancer research (Chicago, Ill.), 2009-04, Vol.69 (7), p.3060-3068

2009

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Dual melanocortin‐4 receptor and GLP‐1 receptor agonism amplifies metabolic benefits in diet‐induced obese mice

EMBO molecular medicine, 2015-03, Vol.7 (3), p.288-298

2015

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Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists

Molecular endocrinology (Baltimore, Md.), 2015-11, Vol.29 (11), p.1619-1633

2015

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Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity

Hepatology communications, 2021-08, Vol.5 (8), p.1412-1425

2021

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Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity

Journal of medicinal chemistry, 2006-12, Vol.49 (26), p.7584-7587

2006

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Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

Molecular and Cellular Biology, 2002-07, Vol.22 (14), p.5027-5035

2002

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Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity

Biochemistry (Easton), 2004-05, Vol.43 (20), p.6091-6100

2004

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Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Molecular metabolism (Germany), 2017-10, Vol.6 (10), p.1321-1329

2017

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neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (18), p.7154-7158

2006

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Magel2‐null mice are hyper‐responsive to setmelanotide, a melanocortin 4 receptor agonist

British journal of pharmacology, 2016-09, Vol.173 (17), p.2614-2621

2016

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Melanin-Concentrating Hormone Receptor Subtypes 1 and 2: Species-Specific Gene Expression

Genomics (San Diego, Calif.), 2002-06, Vol.79 (6), p.785-792

2002

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Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

European journal of pharmacology, 2003-08, Vol.475 (1), p.37-47

2003

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Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade

American journal of physiology. Regulatory, integrative and comparative physiology, 2000-07, Vol.279 (1), p.47-R52

2000

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A Pair-Feeding Study Reveals That a Y5 Antagonist Causes Weight Loss in Diet-Induced Obese Mice by Modulating Food Intake and Energy Expenditure

Molecular pharmacology, 2007-02, Vol.71 (2), p.602-608

2007

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Effects of a Novel Y5 Antagonist in Obese Mice: Combination With Food Restriction or Sibutramine

Obesity (Silver Spring, Md.), 2008-07, Vol.16 (7), p.1510-1515

2008

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Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

Nature (London), 1997-05, Vol.387 (6630), p.288-292

1997

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Role of the Y1 Receptor in the Regulation of Neuropeptide Y-Mediated Feeding: Comparison of Wild-Type, Y1 Receptor-Deficient, and Y5 Receptor-Deficient Mice

Endocrinology (Philadelphia), 2000-03, Vol.141 (3), p.1011-1016

2000

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2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (20), p.5270-5274

2006

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Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

Nature (London), 1994-10, Vol.371 (6499), p.707-711

1994

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RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals

Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia

Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation

Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment

Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs

Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells

Dual melanocortin‐4 receptor and GLP‐1 receptor agonism amplifies metabolic benefits in diet‐induced obese mice

Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists

Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity

Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity

Design and Pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice

Magel2‐null mice are hyper‐responsive to setmelanotide, a melanocortin 4 receptor agonist

Melanin-Concentrating Hormone Receptor Subtypes 1 and 2: Species-Specific Gene Expression

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade

A Pair-Feeding Study Reveals That a Y5 Antagonist Causes Weight Loss in Diet-Induced Obese Mice by Modulating Food Intake and Energy Expenditure

Effects of a Novel Y5 Antagonist in Obese Mice: Combination With Food Restriction or Sibutramine

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

Role of the Y1 Receptor in the Regulation of Neuropeptide Y-Mediated Feeding: Comparison of Wild-Type, Y1 Receptor-Deficient, and Y5 Receptor-Deficient Mice

2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

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