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Anticancer mechanisms and clinical application of alkylphospholipids

Biochimica et biophysica acta, 2013-03, Vol.1831 (3), p.663-674

2013

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Ceramide: second messenger or modulator of membrane structure and dynamics?

Biochemical journal, 2003-01, Vol.369 (Pt 2), p.199-211

2003

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Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts

Biochemical journal, 2007-01, Vol.401 (2), p.541-549

2007

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Alkyl-lysophospholipid Accumulates in Lipid Rafts and Induces Apoptosis via Raft-dependent Endocytosis and Inhibition of Phosphatidylcholine Synthesis

The Journal of biological chemistry, 2002-10, Vol.277 (42), p.39541-39547

2002

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Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport

The Journal of biological chemistry, 2004-06, Vol.279 (25), p.26167-26175

2004

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Properties and functions of diacylglycerol kinases

Cellular Signalling, 2000-10, Vol.12 (9), p.595-605

2000

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Diacylglycerol kinase-α phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility

Oncogene, 2008-02, Vol.27 (7), p.942-956

2008

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A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells

Molecular cancer therapeutics, 2007-08, Vol.6 (8), p.2337-2345

2007

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Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis

Cancer research (Chicago, Ill.), 1999-05, Vol.59 (10), p.2457-2463

1999

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Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts

Clinical cancer research, 2006-03, Vol.12 (5), p.1615-1622

2006

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N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx

British journal of cancer, 2004-02, Vol.90 (4), p.917-925

2004

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Combining anti-tumor alkyl-phospholipid analogs and radiotherapy: rationale and clinical outlook

Anti-cancer agents in medicinal chemistry, 2014-05, Vol.14 (4), p.618-628

2014

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Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine

Biochemical journal, 2003-09, Vol.374 (Pt 3), p.747-753

2003

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Coformulated N-octanoyl-glucosylceramide improves cellular delivery and cytotoxicity of liposomal doxorubicin

The Journal of pharmacology and experimental therapeutics, 2005-11, Vol.315 (2), p.704-710

2005

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Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy

Cancer treatment reviews, 2007-04, Vol.33 (2), p.191-202

2007

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Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects

Current pharmaceutical design, 2008-07, Vol.14 (21), p.2061-2074

2008

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Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis

International journal of radiation oncology, biology, physics, 2001-02, Vol.49 (2), p.415-419

2001

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The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

FEBS letters, 1994-11, Vol.354 (3), p.263-266

1994

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AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

Radiation oncology (London, England), 2009-10, Vol.4 (1), p.47-47, Article 47

2009

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CD95 (Fas/APO-1) Induces Ceramide Formation and Apoptosis in the Absence of a Functional Acid Sphingomyelinase

The Journal of biological chemistry, 1998-03, Vol.273 (13), p.7560-7565

1998

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CD95/Fas-induced Ceramide Formation Proceeds with Slow Kinetics and Is Not Blocked by Caspase-3/CPP32 Inhibition

The Journal of biological chemistry, 1997-09, Vol.272 (39), p.24308-24312

1997

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14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation

Biochemical journal, 2000-01, Vol.345 Pt 2 (2), p.297-306

2000

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The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis

Radiotherapy and oncology, 1998-06, Vol.47 (3), p.225-232

1998

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Glucosylceramide Synthase Does Not Attenuate the Ceramide Pool Accumulating during Apoptosis Induced by CD95 or Anti-cancer Regimens

The Journal of biological chemistry, 2000-11, Vol.275 (44), p.34810-34817

2000

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Cloning of a Novel Human Diacylglycerol Kinase (DGKÎ¸) Containing Three Cysteine-rich Domains, a Proline-rich Region, and a Pleckstrin Homology Domain with an Overlapping Ras-associating Domain

The Journal of biological chemistry, 1997-04, Vol.272 (16), p.10422-10428

1997

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Anticancer mechanisms and clinical application of alkylphospholipids

Ceramide: second messenger or modulator of membrane structure and dynamics?

Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts

Alkyl-lysophospholipid Accumulates in Lipid Rafts and Induces Apoptosis via Raft-dependent Endocytosis and Inhibition of Phosphatidylcholine Synthesis

Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport

Properties and functions of diacylglycerol kinases

Diacylglycerol kinase-α phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility

A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells

Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis

Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts

N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx

Combining anti-tumor alkyl-phospholipid analogs and radiotherapy: rationale and clinical outlook

Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine

Coformulated N-octanoyl-glucosylceramide improves cellular delivery and cytotoxicity of liposomal doxorubicin

Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy

Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects

Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis

The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

CD95 (Fas/APO-1) Induces Ceramide Formation and Apoptosis in the Absence of a Functional Acid Sphingomyelinase

CD95/Fas-induced Ceramide Formation Proceeds with Slow Kinetics and Is Not Blocked by Caspase-3/CPP32 Inhibition

14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation

The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis

Glucosylceramide Synthase Does Not Attenuate the Ceramide Pool Accumulating during Apoptosis Induced by CD95 or Anti-cancer Regimens

Cloning of a Novel Human Diacylglycerol Kinase (DGKÎ¸) Containing Three Cysteine-rich Domains, a Proline-rich Region, and a Pleckstrin Homology Domain with an Overlapping Ras-associating Domain

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