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JNJ-26481585, a Novel “Second-Generation” Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity

Clinical cancer research, 2009-11, Vol.15 (22), p.6841-6851

2009

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Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Angewandte Chemie (International ed.), 2012-05, Vol.51 (19), p.4637-4640

2012

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Histone deacetylase inhibitors: from chromatin remodeling to experimental cancer therapeutics

Current medicinal chemistry, 2003-11, Vol.10 (22), p.2343-2350

2003

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Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.310-317

2013

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Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.294-298

2010

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Diastereoselective Intramolecular Ritter Reaction: Generation of a Cis-Fused Hexahydro-4aH-indeno[1,2-b]pyridine Ring System with 4a,9b-Diangular Substituents

Organic letters, 2000-10, Vol.2 (20), p.3083-3086

2000

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CXCR4 as a novel target in immunology: moving away from typical antagonists

Future drug discovery, 2022-06, Vol.4 (2), p.FDD77

2022

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Synthesis and evaluation of novel HCV replication inhibitors

Molecular diversity, 2017-05, Vol.21 (2), p.475-481

2017

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2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.8150-8160

2010

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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4437-4443

2012

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1,5-Benzodiazepine inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2492-2496

2009

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Synthesis of cis-fused hexahydro-4aH-indeno[1,2-b]pyridines via intramolecular Ritter reaction and their conversion into tricyclic analogues of NK-1 and dopamine receptor ligands

Tetrahedron, 2002-05, Vol.58 (21), p.4225-4236

2002

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Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4431-4436

2012

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Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors

European journal of medicinal chemistry, 2005-06, Vol.40 (6), p.597-606

2005

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Novel analogues of 3-substituted-2,3-dihydro-1,4-dioxino[2,3- b]pyridines: modifications in the dioxane ring

Tetrahedron letters, 2003-11, Vol.44 (47), p.8545-8548

2003

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Synthesis of novel aza analogues of 2-substituted-2,3-dihydro-1,4-benzodioxins as potential new scaffolds for drug discovery

Tetrahedron letters, 2003-03, Vol.44 (11), p.2275-2277

2003

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cis-Fused hexahydro-4aH-indeno[1,2-b]pyridines: transformation of bridgehead ester group and conversion to tricyclic analogues of NK-1 and dopamine receptor ligands

Tetrahedron letters, 2001-07, Vol.42 (29), p.4919-4922

2001

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Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Angewandte Chemie, 2012-05, Vol.124 (19), p.4715-4718

2012

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cis-Fused hexahydro-4a H-indeno[1,2- b]pyridines: transformation of bridgehead ester group and conversion to tricyclic analogues of NK-1 and dopamine receptor ligands

Tetrahedron letters, 2001, Vol.42 (29), p.4919-4922

2001

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Synthesis of cis-fused hexahydro-4a H-indeno[1,2- b]pyridines via intramolecular Ritter reaction and their conversion into tricyclic analogues of NK-1 and dopamine receptor ligands

Tetrahedron, 2002, Vol.58 (21), p.4225-4236

2002

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Histone Deacetylase Inhibitors: From Chromatin Remodelling to Experimental Cancer Therapeutics

Frontiers in Medicinal Chemistry - Online, 2005-01, Vol.2 (1), p.299-315

2005

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Diastereoselective Intramolecular Ritter Reaction: Generation of a Cis- Fused Hexahydro-4a H -indeno[1,2- b ]pyridine Ring System with 4a,9b-Diangular Substituents

Organic letters, 2000-10, Vol.2 (20), p.3083-3086

2000

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Synthesis of cis-Fused Hexahydro-4aH-indeno[1,2-b]pyridines via Intramolecular Ritter Reaction and Their Conversion into Tricyclic Analogues of NK-1 and Dopamine Receptor Ligands

ChemInform, 2002-10, Vol.33 (41), p.146-146

2002

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Novel Analogues of 3-Substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines: Modifications in the Dioxane Ring

ChemInform, 2004-03, Vol.35 (9), p.no-no

2004

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ChemInform Abstract: Diastereoselective Intramolecular Ritter Reaction: Generation of a cis-Fused Hexahydro-4aH-indeno[1,2-b]pyridine Ring System with 4a,9b-Diangular Substituents

ChemInform, 2001-02, Vol.32 (6), p.no-no

2001

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JNJ-26481585, a Novel “Second-Generation” Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity

Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Histone deacetylase inhibitors: from chromatin remodeling to experimental cancer therapeutics

Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application

Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors

Diastereoselective Intramolecular Ritter Reaction: Generation of a Cis-Fused Hexahydro-4aH-indeno[1,2-b]pyridine Ring System with 4a,9b-Diangular Substituents

CXCR4 as a novel target in immunology: moving away from typical antagonists

Synthesis and evaluation of novel HCV replication inhibitors

2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase

Synthesis of cis-fused hexahydro-4aH-indeno[1,2-b]pyridines via intramolecular Ritter reaction and their conversion into tricyclic analogues of NK-1 and dopamine receptor ligands

Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series

Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors

Novel analogues of 3-substituted-2,3-dihydro-1,4-dioxino[2,3- b]pyridines: modifications in the dioxane ring

Synthesis of novel aza analogues of 2-substituted-2,3-dihydro-1,4-benzodioxins as potential new scaffolds for drug discovery

cis-Fused hexahydro-4aH-indeno[1,2-b]pyridines: transformation of bridgehead ester group and conversion to tricyclic analogues of NK-1 and dopamine receptor ligands

Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

cis-Fused hexahydro-4a H-indeno[1,2- b]pyridines: transformation of bridgehead ester group and conversion to tricyclic analogues of NK-1 and dopamine receptor ligands

Synthesis of cis-fused hexahydro-4a H-indeno[1,2- b]pyridines via intramolecular Ritter reaction and their conversion into tricyclic analogues of NK-1 and dopamine receptor ligands

Histone Deacetylase Inhibitors: From Chromatin Remodelling to Experimental Cancer Therapeutics

Diastereoselective Intramolecular Ritter Reaction: Generation of a Cis- Fused Hexahydro-4a H -indeno[1,2- b ]pyridine Ring System with 4a,9b-Diangular Substituents

Synthesis of cis-Fused Hexahydro-4aH-indeno[1,2-b]pyridines via Intramolecular Ritter Reaction and Their Conversion into Tricyclic Analogues of NK-1 and Dopamine Receptor Ligands

Novel Analogues of 3-Substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines: Modifications in the Dioxane Ring

ChemInform Abstract: Diastereoselective Intramolecular Ritter Reaction: Generation of a cis-Fused Hexahydro-4aH-indeno[1,2-b]pyridine Ring System with 4a,9b-Diangular Substituents

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