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Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

Nature cell biology, 2002-02, Vol.4 (2), p.95-105

2002

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Nature (London), 1995-07, Vol.376 (6535), p.37-43

1995

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Confinement of caspase-12 proteolytic activity to autoprocessing

Proceedings of the National Academy of Sciences - PNAS, 2008-03, Vol.105 (11), p.4133-4138

2008

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Purification and catalytic properties of human caspase family members

Cell death and differentiation, 1999-04, Vol.6 (4), p.362-369

1999

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High-frequency transposition for determining antibacterial mode of action

Nature chemical biology, 2011-10, Vol.7 (10), p.720

2011

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Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics

The Journal of experimental medicine, 2004-01, Vol.199 (2), p.199-207

2004

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Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

Nature, 2004-05, Vol.429 (6987), p.75-79

2004

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A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation

The Journal of biological chemistry, 2004-07, Vol.279 (27), p.27905-27914

2004

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The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

Nature structural biology, 1996-07, Vol.3 (7), p.619-625

1996

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Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

Cell death and differentiation, 1998-04, Vol.5 (4), p.271-288

1998

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Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases (∗)

The Journal of biological chemistry, 1995-06, Vol.270 (26), p.15870-15876

1995

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Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.805-808

2004

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Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1671-1674

2007

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Nicotinyl aspartyl ketones as inhibitors of caspase-3

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (13), p.2137-2140

2003

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Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors

Bioorganic & medicinal chemistry letters, 2005-09, Vol.15 (17), p.3886-3890

2005

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Solid phase synthesis of selective caspase-3 peptide inhibitors

Bioorganic & medicinal chemistry, 2004-03, Vol.12 (5), p.845-851

2004

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

The Journal of biological chemistry, 1997-07, Vol.272 (29), p.17907

1997

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Genomic organization of the human caspase-9 gene on Chromosome 1p36.1-p36.3

Mammalian genome, 1999-07, Vol.10 (7), p.757-760

1999

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A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

The Journal of biological chemistry, 1997-07, Vol.272 (29), p.17907-17911

1997

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Intact Cell Evidence for the Early Synthesis, and Subsequent Late Apopain-Mediated Suppression, of Poly(ADP-ribose) during Apoptosis

Experimental cell research, 1997-05, Vol.232 (2), p.313-321

1997

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Lipophilic versus hydrogen-bonding effect in P 3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors

Bioorganic & medicinal chemistry letters, 2005-09, Vol.15 (17), p.3886-3890

2005

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Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits

Proceedings of the National Academy of Sciences - PNAS, 1993-03, Vol.90 (5), p.2015-2019

1993

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Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells

Molecular pharmacology, 1994-05, Vol.45 (5), p.1043-1049

1994

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Interleukin-1[alpha]-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3

Mammalian genome, 1997-08, Vol.8 (8), p.611

1997

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Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Confinement of caspase-12 proteolytic activity to autoprocessing

Purification and catalytic properties of human caspase family members

High-frequency transposition for determining antibacterial mode of action

Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases (∗)

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones

Nicotinyl aspartyl ketones as inhibitors of caspase-3

Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors

Solid phase synthesis of selective caspase-3 peptide inhibitors

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

Genomic organization of the human caspase-9 gene on Chromosome 1p36.1-p36.3

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

Intact Cell Evidence for the Early Synthesis, and Subsequent Late Apopain-Mediated Suppression, of Poly(ADP-ribose) during Apoptosis

Lipophilic versus hydrogen-bonding effect in P 3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors

Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits

Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells

Interleukin-1[alpha]-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3

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