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Atazanavir: effects on P-glycoprotein transport and CYP3A metabolism in vitro

Drug metabolism and disposition, 2005-06, Vol.33 (6), p.764-770

2005

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Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models

Journal of clinical pharmacology, 2001-11, Vol.41 (11), p.1149-1179

2001

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The influence of age and sex on the clearance of cytochrome P450 3A substrates

Clinical pharmacokinetics, 2005, Vol.44 (1), p.33-60

2005

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In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5

Drug metabolism and disposition, 2003-07, Vol.31 (7), p.938-944

2003

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Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine

Drug metabolism and disposition, 2003-03, Vol.31 (3), p.289-293

2003

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Effects of the antifungal agents on oxidative drug metabolism: Clinical relevance

Clinical pharmacokinetics, 2000-02, Vol.38 (2), p.111-180

2000

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CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants

Drug metabolism and disposition, 2000-10, Vol.28 (10), p.1176

2000

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Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms

The Journal of pharmacology and experimental therapeutics, 2001-12, Vol.299 (3), p.998

2001

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Saint John's wort: An in vitro analysis of P‐glycoprotein induction due to extended exposure

British journal of pharmacology, 2001-12, Vol.134 (8), p.1601-1608

2001

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Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: Effect of ketoconazole

Clinical pharmacology and therapeutics, 1999-11, Vol.66 (5), p.461-471

1999

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Gender Has a Small but Statistically Significant Effect on Clearance of CYP3A Substrate Drugs

Journal of clinical pharmacology, 2008-11, Vol.48 (11), p.1350-1355

2008

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Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches

Drug metabolism and disposition, 2000-12, Vol.28 (12), p.1493

2000

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UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S)

The Journal of pharmacology and experimental therapeutics, 2005-06, Vol.313 (3), p.1340-1346

2005

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Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram

Drug metabolism and disposition, 2001-08, Vol.29 (8), p.1102

2001

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Inhibition of human cytochromes P450 by components of Ginkgo biloba

Journal of pharmacy and pharmacology, 2004-08, Vol.56 (8), p.1039-1044

2004

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Drug metabolism and drug interactions: application and clinical value of in vitro models

Current drug metabolism, 2003-10, Vol.4 (5), p.423-459

2003

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Pharmacokinetic and Pharmacodynamic Interactions Between Zolpidem and Caffeine

Clinical pharmacology and therapeutics, 2007-07, Vol.82 (1), p.54-62

2007

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Mechanism of cytochrome P450-3A inhibition by ketoconazole

Journal of pharmacy and pharmacology, 2011-02, Vol.63 (2), p.214-221

2011

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UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.656-665

2004

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Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

Drug metabolism and disposition, 2002-11, Vol.30 (11), p.1257-1265

2002

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Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4

Drug metabolism and disposition, 2000-10, Vol.28 (10), p.1168

2000

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In Vitro Approaches to Predicting Drug Interactions In Vivo

Biochemical pharmacology, 1998, Vol.55 (2), p.113-122

1998

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Interaction of Warfarin With Drugs, Natural Substances, and Foods

Journal of clinical pharmacology, 2005-02, Vol.45 (2), p.127-132

2005

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Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate

The Journal of pharmacology and experimental therapeutics, 2001-04, Vol.297 (1), p.326

2001

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Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6

Drug metabolism and disposition, 2003-01, Vol.31 (1), p.133-139

2003

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Atazanavir: effects on P-glycoprotein transport and CYP3A metabolism in vitro

Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models

The influence of age and sex on the clearance of cytochrome P450 3A substrates

In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5

Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine

Effects of the antifungal agents on oxidative drug metabolism: Clinical relevance

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms

Saint John's wort: An in vitro analysis of P‐glycoprotein induction due to extended exposure

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: Effect of ketoconazole

Gender Has a Small but Statistically Significant Effect on Clearance of CYP3A Substrate Drugs

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S)

Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram

Inhibition of human cytochromes P450 by components of Ginkgo biloba

Drug metabolism and drug interactions: application and clinical value of in vitro models

Pharmacokinetic and Pharmacodynamic Interactions Between Zolpidem and Caffeine

Mechanism of cytochrome P450-3A inhibition by ketoconazole

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4

In Vitro Approaches to Predicting Drug Interactions In Vivo

Interaction of Warfarin With Drugs, Natural Substances, and Foods

Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate

Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6

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