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Translational systems biology of inflammation and healing

Wound repair and regeneration, 2010-01, Vol.18 (1), p.3-7

Vodovotz, Yoram

2010

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Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

JAMA : the journal of the American Medical Association, 2019-05, Vol.321 (20), p.2003

2019

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Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-Based Precision Medicine

2nd Edition 2021, 2020

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Towards systems immunology of critical illness at scale: from single cell ‘omics to digital twins

Trends in immunology, 2023-05, Vol.44 (5), p.345-355

Vodovotz, Yoram

2023

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Editorial: Combining mechanistic modeling with machine learning to study multiscale biological processes

Frontiers in Systems Biology (Online), 2024-02, Vol.4

2024

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IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model

PLoS medicine, 2017-07, Vol.14 (7), p.e1002365

2017

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Time for trauma immunology

PLoS medicine, 2017-07, Vol.14 (7), p.e1002342-e1002342

2017

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Translational systems biology of inflammation

PLoS computational biology, 2008-04, Vol.4 (4), p.e1000014-e1000014

2008

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A putative "chemokine switch" that regulates systemic acute inflammation in humans

Scientific reports, 2021-05, Vol.11 (1), p.9703-9703, Article 9703

2021

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Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks

Molecular medicine (Cambridge, Mass.), 2021-06, Vol.27 (1), p.65-65, Article 65

2021

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Therapeutic strategies in inflammasome mediated diseases of the liver

Journal of hepatology, 2013-05, Vol.58 (5), p.1047-1052

2013

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Translational Systems Biology: Concepts and Practice for the Future of Biomedical Research

1, 2014

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Dynamics of Systemic Inflammation as a Function of Developmental Stage in Pediatric Acute Liver Failure

Frontiers in immunology, 2021-01, Vol.11, p.610861-610861

2021

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Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure

PloS one, 2013-11, Vol.8 (11), p.e78202-e78202

2013

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Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model

Frontiers in immunology, 2021-10, Vol.12, p.754127-754127

2021

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Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies

PloS one, 2013-12, Vol.8 (12), p.e79804-e79804

2013

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Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties

Scientific reports, 2023-04, Vol.13 (1), p.6618-6618, Article 6618

2023

Volltextzugriff (PDF)

What’s next for computational systems biology?

Frontiers in Systems Biology (Online), 2023-09, Vol.3

2023

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Effect of CHRFAM7A Δ2bp gene variant on secondary inflammation after spinal cord injury

PloS one, 2021-05, Vol.16 (5), p.e0251110-e0251110

2021

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Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study

International urology and nephrology, 2010-09, Vol.42 (3), p.629-635

2010

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Hemorrhagic Shock Induces NAD(P)H Oxidase Activation in Neutrophils: Role of HMGB1-TLR4 Signaling

Journal of Immunology, 2007-05, Vol.178 (10), p.6573-6580

2007

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A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice

PLoS computational biology, 2018-11, Vol.14 (11), p.e1006582-e1006582

2018

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A multiscale inflammatory map: linking individual stress to societal dysfunction

Frontiers in Science, 2024-03, Vol.1

2024

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The influence of microbial colonization on inflammatory versus pro-healing trajectories in combat extremity wounds

Scientific reports, 2024-03, Vol.14 (1), p.5006-5006, Article 5006

2024

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Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries

PloS one, 2019-06, Vol.14 (6), p.e0217577

2019

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Translational systems biology of inflammation and healing

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-Based Precision Medicine

Towards systems immunology of critical illness at scale: from single cell ‘omics to digital twins

Editorial: Combining mechanistic modeling with machine learning to study multiscale biological processes

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model

Time for trauma immunology

Translational systems biology of inflammation

A putative "chemokine switch" that regulates systemic acute inflammation in humans

Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks

Therapeutic strategies in inflammasome mediated diseases of the liver

Translational Systems Biology: Concepts and Practice for the Future of Biomedical Research

Dynamics of Systemic Inflammation as a Function of Developmental Stage in Pediatric Acute Liver Failure

Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure

Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model

Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies

Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties

What’s next for computational systems biology?

Effect of CHRFAM7A Δ2bp gene variant on secondary inflammation after spinal cord injury

Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study

Hemorrhagic Shock Induces NAD(P)H Oxidase Activation in Neutrophils: Role of HMGB1-TLR4 Signaling

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice

A multiscale inflammatory map: linking individual stress to societal dysfunction

The influence of microbial colonization on inflammatory versus pro-healing trajectories in combat extremity wounds

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries

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