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Pour une meilleure approche des taux de ciclosporine (Sandimmun)

Immuno-analyse & biologie spécialisée, 1992, Vol.7 (5), p.43-45

Vernillet, L

1992

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Multicentre phase II study and pharmacokinetic analysis of irinotecan in chemotherapy-naive patients with glioblastoma

Annals of oncology, 2003-04, Vol.14 (4), p.603-614

2003

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Phase I Dose-Finding Study of a New Taxane, RPR 109881A, Administered as a One-Hour Intravenous Infusion Days 1 and 8 to Patients With Advanced Solid Tumors

Journal of clinical oncology, 2000-12, Vol.18 (24), p.4098-4108

2000

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Effects of age and gender on febuxostat pharmacokinetics, pharmacodynamics, and safety in healthy subjects

Clinical pharmacology and therapeutics, 2005-02, Vol.77 (2), p.P50-P50

2005

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Effect of food or antacid on febuxostat pharmacokinetics and pharmacodynamics in healthy subjects

Clinical pharmacology and therapeutics, 2005-02, Vol.77 (2), p.P50-P50

2005

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Effect of febuxostat on pharmacokinetics of desipramine, a CYP2D6 substrate, in healthy subjects

Clinical pharmacology and therapeutics, 2005-02, Vol.77 (2), p.P43-P43

2005

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Metabolism of Irinotecan (CPT-11) by CYP3A4 and CYP3A5 in Humans

Clinical cancer research, 2000-05, Vol.6 (5), p.2012

2000

Volltextzugriff (PDF)

The Effect of Mild and Moderate Hepatic Impairment on Pharmacokinetics, Pharmacodynamics, and Safety of Febuxostat, a Novel Nonpurine Selective Inhibitor of Xanthine Oxidase

Journal of clinical pharmacology, 2006-01, Vol.46 (1), p.88-102

2006

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Docetaxel in combination with 5-fluorouracil in patients with metastatic breast cancer previously treated with anthracycline-based chemotherapy: a phase I, dose-finding study

European journal of cancer (1990), 2000-09, Vol.36 (14), p.1773-1780

2000

Volltextzugriff (PDF)

Pharmacokinetics and pharmacodynamics of febuxostat, a new non-purine selective inhibitor of xanthine oxidase in subjects with renal impairment

American journal of therapeutics, 2005-01, Vol.12 (1), p.22

2005

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Phase I study of irinotecan and raltitrexed in patients with advanced gastrointestinal tract adenocarcinoma

British journal of cancer, 2000-07, Vol.83 (2), p.146-152

2000

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Dosage Adjustment and Pharmacokinetic Profile of Irinotecan in Cancer Patients With Hepatic Dysfunction

Journal of clinical oncology, 2002-11, Vol.20 (21), p.4303-4312

2002

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Phase I dose-finding and pharmacokinetic study of docetaxel and vinorelbine as first-line chemotherapy for metastatic breast cancer

Annals of oncology, 2001-07, Vol.12 (7), p.909-918

2001

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Phase I study of docetaxel in combination with cyclophosphamide as first-line chemotherapy for metastatic breast cancer

British journal of cancer, 2002-11, Vol.87 (10), p.1072-1078

2002

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355 POSTER Updated safety and efficacy data from a first-in-human, first-in-class, phase I study of Hedgehog pathway antagonist, GDC-0449

European journal of cancer supplements, 2008, Vol.6 (12), p.112-113

2008

Volltextzugriff (PDF)

A rapid reversed phase high performance liquid chromatographic method for the determination of docetaxel (Taxotere®) in human plasma using a column switching technique

Journal of pharmaceutical and biomedical analysis, 1998-09, Vol.17 (8), p.1243-1247

1998

Volltextzugriff (PDF)

Metabolism of irinotecan (CPT-11) by human hepatic microsomes : Participation of cytochrome P-450 3A and drug interactions

Cancer research (Chicago, Ill.), 1998-02, Vol.58 (3), p.468-472

1998

Volltextzugriff (PDF)

PI-55Population pharmacokinetics and pharmacodynamics of febuxostat in a phase-III study of patients with gout

Clinical pharmacology and therapeutics, 2006-02, Vol.79 (2), p.P21-P21

2006

Volltextzugriff (PDF)

PI-70Effect of erythromycin on the pharmacokinetics of asoprisnil and its active metabolite J912 in healthy female subjects

Clinical pharmacology and therapeutics, 2006-02, Vol.79 (2), p.P25-P25

2006

Volltextzugriff (PDF)

PI-55

Clinical pharmacology and therapeutics, 2006-02, Vol.79 (2), p.P21-P21

2006

Volltextzugriff (PDF)

PI-70

Clinical pharmacology and therapeutics, 2006-02, Vol.79 (2), p.P25-P25

2006

Volltextzugriff (PDF)

A first-in-human, first-in-class, phase (ph) I study of systemic Hedgehog (Hh) pathway antagonist, GDC-0449, in patients (pts) with advanced solid tumors

Journal of clinical oncology, 2008-05, Vol.26 (15_suppl), p.3516-3516

2008

Volltextzugriff (PDF)

Pharmacokinetic, Metabolic, and Pharmacodynamic Profiles in a Dose-Escalating Study of Irinotecan and Cisplatin

Journal of clinical oncology, 2000-01, Vol.18 (1), p.195-203

2000

Volltextzugriff (PDF)

Phase I and Pharmacokinetic Study of Irinotecan Administered as a Low-Dose, Continuous Intravenous Infusion Over 14 Days in Patients With Malignant Solid Tumors

Journal of clinical oncology, 1999-06, Vol.17 (6), p.1897-1905

1999

Volltextzugriff (PDF)

A Phase I Study of Docetaxel Plus Cyclophosphamide in Solid Tumors followed by a Phase II Study as First-Line Therapy in Metastatic Breast Cancer

Clinical cancer research, 2003-07, Vol.9 (7), p.2426

2003

Volltextzugriff (PDF)

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Pour une meilleure approche des taux de ciclosporine (Sandimmun)

Multicentre phase II study and pharmacokinetic analysis of irinotecan in chemotherapy-naive patients with glioblastoma

Phase I Dose-Finding Study of a New Taxane, RPR 109881A, Administered as a One-Hour Intravenous Infusion Days 1 and 8 to Patients With Advanced Solid Tumors

Effects of age and gender on febuxostat pharmacokinetics, pharmacodynamics, and safety in healthy subjects

Effect of food or antacid on febuxostat pharmacokinetics and pharmacodynamics in healthy subjects

Effect of febuxostat on pharmacokinetics of desipramine, a CYP2D6 substrate, in healthy subjects

Metabolism of Irinotecan (CPT-11) by CYP3A4 and CYP3A5 in Humans

The Effect of Mild and Moderate Hepatic Impairment on Pharmacokinetics, Pharmacodynamics, and Safety of Febuxostat, a Novel Nonpurine Selective Inhibitor of Xanthine Oxidase

Docetaxel in combination with 5-fluorouracil in patients with metastatic breast cancer previously treated with anthracycline-based chemotherapy: a phase I, dose-finding study

Pharmacokinetics and pharmacodynamics of febuxostat, a new non-purine selective inhibitor of xanthine oxidase in subjects with renal impairment

Phase I study of irinotecan and raltitrexed in patients with advanced gastrointestinal tract adenocarcinoma

Dosage Adjustment and Pharmacokinetic Profile of Irinotecan in Cancer Patients With Hepatic Dysfunction

Phase I dose-finding and pharmacokinetic study of docetaxel and vinorelbine as first-line chemotherapy for metastatic breast cancer

Phase I study of docetaxel in combination with cyclophosphamide as first-line chemotherapy for metastatic breast cancer

355 POSTER Updated safety and efficacy data from a first-in-human, first-in-class, phase I study of Hedgehog pathway antagonist, GDC-0449

A rapid reversed phase high performance liquid chromatographic method for the determination of docetaxel (Taxotere®) in human plasma using a column switching technique

Metabolism of irinotecan (CPT-11) by human hepatic microsomes : Participation of cytochrome P-450 3A and drug interactions

PI-55Population pharmacokinetics and pharmacodynamics of febuxostat in a phase-III study of patients with gout

PI-70Effect of erythromycin on the pharmacokinetics of asoprisnil and its active metabolite J912 in healthy female subjects

PI-55

PI-70

A first-in-human, first-in-class, phase (ph) I study of systemic Hedgehog (Hh) pathway antagonist, GDC-0449, in patients (pts) with advanced solid tumors

Pharmacokinetic, Metabolic, and Pharmacodynamic Profiles in a Dose-Escalating Study of Irinotecan and Cisplatin

Phase I and Pharmacokinetic Study of Irinotecan Administered as a Low-Dose, Continuous Intravenous Infusion Over 14 Days in Patients With Malignant Solid Tumors

A Phase I Study of Docetaxel Plus Cyclophosphamide in Solid Tumors followed by a Phase II Study as First-Line Therapy in Metastatic Breast Cancer

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