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Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

Nature biotechnology, 2017-09, Vol.35 (9), p.845-851

2017

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The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members

Clinical cancer research, 2007-12, Vol.13 (24), p.7264-7270

2007

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Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

Nature biotechnology, 2016-07, Vol.34 (7), p.738-745

2016

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Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (44), p.17942-17947

2012

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Direct inhibition of the NOTCH transcription factor complex

Nature (London), 2009-11, Vol.462 (7270), p.182-188

2009

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Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase

The Journal of biological chemistry, 2017-03, Vol.292 (12), p.5007-5017

2017

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Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide

Journal of the American Chemical Society, 2007-03, Vol.129 (9), p.2456-2457

2007

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Nonspecifically bound proteins spin while diffusing along DNA

Nature structural & molecular biology, 2009-12, Vol.16 (12), p.1224-1229

2009

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Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (44), p.18497-18502

2009

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The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase

Nature communications, 2020-09, Vol.11 (1), p.4437-4437, Article 4437

2020

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Regulation of MLL1 H3K4 methyltransferase activity by its core components

Nature structural & molecular biology, 2006-08, Vol.13 (8), p.713-719

2006

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Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA

Nature (London), 2005-03, Vol.434 (7033), p.612-618

2005

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Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

Nature communications, 2017-09, Vol.8 (1), p.660-11, Article 660

2017

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Recognition and reprogramming of E3 ubiquitin ligase surfaces by α-helical peptides

Nature communications, 2023-11, Vol.14 (1), p.6992-6992, Article 6992

2023

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A Base-Excision DNA-Repair Protein Finds Intrahelical Lesion Bases by Fast Sliding in Contact with DNA

Proceedings of the National Academy of Sciences - PNAS, 2006-04, Vol.103 (15), p.5752-5757

2006

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Mirror-image ligand discovery enabled by single-shot fast-flow synthesis of D-proteins

Nature communications, 2024-02, Vol.15 (1), p.1813-1813, Article 1813

2024

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Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix

Science (American Association for the Advancement of Science), 2004-09, Vol.305 (5689), p.1466-1470

2004

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Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme

Nature (London), 2009-12, Vol.462 (7274), p.762-766

2009

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IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex

Cell reports (Cambridge), 2017-01, Vol.18 (2), p.432-442

2017

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Structure of a DNA Glycosylase Searching for Lesions

Science (American Association for the Advancement of Science), 2006-02, Vol.311 (5764), p.1153-1157

2006

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Stapled Peptides for Intracellular Drug Targets

Methods in Enzymology, 2012, Vol.503, p.3-33

2012

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An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides

Journal of the American Chemical Society, 2000-06, Vol.122 (24), p.5891-5892

2000

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Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase

The Journal of biological chemistry, 2005-11, Vol.280 (44), p.37041-37047

2005

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Stereochemical effects of all-hydrocarbon tethers in i, i+4 stapled peptides

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2533-2536

2009

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DNA Lesion Recognition by the Bacterial Repair Enzyme MutM

The Journal of biological chemistry, 2003-12, Vol.278 (51), p.51543-51548

2003

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Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Direct inhibition of the NOTCH transcription factor complex

Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase

Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide

Nonspecifically bound proteins spin while diffusing along DNA

Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase

The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase

Regulation of MLL1 H3K4 methyltransferase activity by its core components

Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA

Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

Recognition and reprogramming of E3 ubiquitin ligase surfaces by α-helical peptides

A Base-Excision DNA-Repair Protein Finds Intrahelical Lesion Bases by Fast Sliding in Contact with DNA

Mirror-image ligand discovery enabled by single-shot fast-flow synthesis of D-proteins

Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix

Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme

IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex

Structure of a DNA Glycosylase Searching for Lesions

Stapled Peptides for Intracellular Drug Targets

An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides

Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase

Stereochemical effects of all-hydrocarbon tethers in i, i+4 stapled peptides

DNA Lesion Recognition by the Bacterial Repair Enzyme MutM

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