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Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

Diabetes (New York, N.Y.), 2009-01, Vol.58 (1), p.250-259

2009

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Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies for the Treatment of Obesity, Do Agonists = Antagonists?

Endocrine reviews, 2020-02, Vol.41 (1), p.1-21

2020

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Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

Endocrinology (Philadelphia), 2012-01, Vol.153 (1), p.69-80

2012

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Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

Endocrinology (Philadelphia), 2012-09, Vol.153 (9), p.4192-4203

2012

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Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects

American journal of physiology: endocrinology and metabolism, 2009-11, Vol.297 (5), p.E1105-E1114

2009

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

Nature (London), 2013-12, Vol.504 (7480), p.437-440

2013

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FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists

Journal of bone and mineral research, 2017-04, Vol.32 (4), p.834-845

2017

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Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

Cell metabolism, 2015-05, Vol.21 (5), p.731-738

2015

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Co-receptor Requirements for Fibroblast Growth Factor-19 Signaling

The Journal of biological chemistry, 2007-10, Vol.282 (40), p.29069-29072

2007

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Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity

Journal of medicinal chemistry, 2008-05, Vol.51 (9), p.2758-2765

2008

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Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

Diabetes (New York, N.Y.), 2006-07, Vol.55 (7), p.2042-2050

2006

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Growth differentiation factor 15 as a potential therapeutic for treating obesity

Molecular metabolism (Germany), 2021-04, Vol.46, p.101117-101117, Article 101117

2021

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Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

Science translational medicine, 2017-10, Vol.9 (412)

2017

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Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Nature communications, 2020-10, Vol.11 (1), p.4981-4981, Article 4981

2020

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Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

PloS one, 2012-11, Vol.7 (11), p.e49345-e49345

2012

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FGF21 promotes metabolic homeostasis via white adipose and leptin in mice

PloS one, 2012-07, Vol.7 (7), p.e40164

2012

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Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice

Arteriosclerosis, thrombosis, and vascular biology, 2001-10, Vol.21 (10), p.1567-1570

2001

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The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15

PloS one, 2020-08, Vol.15 (8), p.e0231234-e0231234

2020

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FGF21 acts as a negative regulator of bile acid synthesis

Journal of endocrinology, 2018-05, Vol.237 (2), p.139-152

2018

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A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice

Lipids in health and disease, 2014-10, Vol.13 (1), p.167-167, Article 167

2014

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Hsa-miRNA-23a-3p promotes atherogenesis in a novel mouse model of atherosclerosis

Journal of lipid research, 2020-12, Vol.61 (12), p.1764-1775

2020

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Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

Science translational medicine, 2018-12, Vol.10 (472)

2018

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A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys

Endocrinology (Philadelphia), 2017-05, Vol.158 (5), p.1314-1327

2017

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FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPAR[alpha] and PPAR[gamma] Agonists

Journal of bone and mineral research, 2017-04, Vol.32 (4), p.834

2017

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Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models

Current drug targets, 2008-03, Vol.9 (3), p.174-189

2008

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Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies for the Treatment of Obesity, Do Agonists = Antagonists?

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists

Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

Co-receptor Requirements for Fibroblast Growth Factor-19 Signaling

Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity

Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

Growth differentiation factor 15 as a potential therapeutic for treating obesity

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

FGF21 promotes metabolic homeostasis via white adipose and leptin in mice

Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice

The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15

FGF21 acts as a negative regulator of bile acid synthesis

A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice

Hsa-miRNA-23a-3p promotes atherogenesis in a novel mouse model of atherosclerosis

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys

FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPAR[alpha] and PPAR[gamma] Agonists

Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models

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