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Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?

Frontiers in pharmacology, 2020-11, Vol.11, p.582310

Vela, José Miguel

2020

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Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice

Scientific reports, 2018-03, Vol.8 (1), p.3873-13, Article 3873

2018

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Sigma 1 receptor: A new therapeutic target for pain

European journal of pharmacology, 2013-09, Vol.716 (1-3), p.78-93

2013

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WLB-87848, a Selective σ1 Receptor Agonist, with an Unusually Positioned NH Group as Positive Ionizable Moiety and Showing Neuroprotective Activity

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.9150-9164

2024

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A New Pharmacophore Model for the Design of Sigma-1 Ligands Validated on a Large Experimental Dataset

Frontiers in pharmacology, 2019-05, Vol.10, p.519-519

2019

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Synthesis and Biological Evaluation of the 1‑Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4‑{2-[5-Methyl-1-(naphthalen-2-yl)‑1H‑pyrazol-3-yloxy]ethyl}morpholine (S1RA, E‑52862)

Journal of medicinal chemistry, 2012-10, Vol.55 (19), p.8211-8224

2012

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Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice

The journal of pain, 2012-11, Vol.13 (11), p.1107-1121

2012

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Sigma-1 receptor antagonism as opioid adjuvant strategy: Enhancement of opioid antinociception without increasing adverse effects

European journal of pharmacology, 2013-07, Vol.711 (1-3), p.63-72

2013

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Resilience to Pain-Related Depression in σ1 Receptor Knockout Mice Is Associated with the Reversal of Pain-Induced Brain Changes in Affect-Related Genes

ACS chemical neuroscience, 2023-10, Vol.14 (19), p.3714-3725

2023

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5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice

Pain (Amsterdam), 2009-02, Vol.141 (3), p.239-247

2009

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Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain

Advances in experimental medicine and biology, 2017-01, Vol.964, p.85-107

2017

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Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models

International journal of molecular sciences, 2022-10, Vol.23 (19), p.11933

2022

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Co-crystals as a new approach to multimodal analgesia and the treatment of pain

Journal of Pain Research, 2019-09, Vol.12, p.2679-2689

2019

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Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury

Pain (Amsterdam), 2009-10, Vol.145 (3), p.294-303

2009

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Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice

International journal of molecular sciences, 2023-01, Vol.24 (2), p.1761

2023

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Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice

Pain (Amsterdam), 2008-07, Vol.137 (3), p.520-531

2008

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Synthesis and Structure–Activity Relationship Study of a New Series of Selective σ1 Receptor Ligands for the Treatment of Pain: 4‑Aminotriazoles

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2441-2451

2015

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Mite diversity (Acari: Tetranychidae, Tydeidae, Iolinidae, Phytoseiidae) and within-tree distribution in citrus orchards in southern Spain, with special reference to Eutetranychus orientalis

Experimental & applied acarology, 2017-10, Vol.73 (2), p.191-207

2017

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Predicting the Antinociceptive Efficacy of σ1 Receptor Ligands by a Novel Receptor Fluorescence Resonance Energy Transfer (FRET) Based Biosensor

Journal of medicinal chemistry, 2014-01, Vol.57 (1), p.238-242

2014

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Some techniques for the study of useful characters in the taxonomy of the genus Timarcha Samouelle, 1819 (Coleoptera, Chrysomelidae)

European journal of taxonomy, 2020-04 (630)

2020

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Temperature-specific competition in predatory mites: Implications for biological pest control in a changing climate

Agriculture, ecosystems & environment, 2016-01, Vol.216, p.89-97

2016

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Population Dynamics and Tree Damage of the Invasive Chestnut Gall Wasp, Dryocosmus kuriphilus, in Its Southernmost European Distributional Range

Insects (Basel, Switzerland), 2021-10, Vol.12 (10), p.900

2021

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Prenatal Immune Challenge Disrupts Sensorimotor Gating in Adult Rats: Implications for the Etiopathogenesis of Schizophrenia

Neuropsychopharmacology (New York, N.Y.), 2002-02, Vol.26 (2), p.204-215

2002

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Antidepressive-like Behavior-Related Metabolomic Signatures of Sigma-1 Receptor Knockout Mice

Biomedicines, 2022-07, Vol.10 (7), p.1572

2022

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Potentiation of Morphine Analgesia by Adjuvant Activation of 5-HT7 Receptors

Journal of Pharmacological Sciences, 2011, Vol.116(4), pp.388-391

2011

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Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?

Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice

Sigma 1 receptor: A new therapeutic target for pain

WLB-87848, a Selective σ1 Receptor Agonist, with an Unusually Positioned NH Group as Positive Ionizable Moiety and Showing Neuroprotective Activity

A New Pharmacophore Model for the Design of Sigma-1 Ligands Validated on a Large Experimental Dataset

Synthesis and Biological Evaluation of the 1‑Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4‑{2-[5-Methyl-1-(naphthalen-2-yl)‑1H‑pyrazol-3-yloxy]ethyl}morpholine (S1RA, E‑52862)

Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice

Sigma-1 receptor antagonism as opioid adjuvant strategy: Enhancement of opioid antinociception without increasing adverse effects

Resilience to Pain-Related Depression in σ1 Receptor Knockout Mice Is Associated with the Reversal of Pain-Induced Brain Changes in Affect-Related Genes

5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice

Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain

Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models

Co-crystals as a new approach to multimodal analgesia and the treatment of pain

Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury

Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice

Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice

Synthesis and Structure–Activity Relationship Study of a New Series of Selective σ1 Receptor Ligands for the Treatment of Pain: 4‑Aminotriazoles

Mite diversity (Acari: Tetranychidae, Tydeidae, Iolinidae, Phytoseiidae) and within-tree distribution in citrus orchards in southern Spain, with special reference to Eutetranychus orientalis

Predicting the Antinociceptive Efficacy of σ1 Receptor Ligands by a Novel Receptor Fluorescence Resonance Energy Transfer (FRET) Based Biosensor

Some techniques for the study of useful characters in the taxonomy of the genus Timarcha Samouelle, 1819 (Coleoptera, Chrysomelidae)

Temperature-specific competition in predatory mites: Implications for biological pest control in a changing climate

Population Dynamics and Tree Damage of the Invasive Chestnut Gall Wasp, Dryocosmus kuriphilus, in Its Southernmost European Distributional Range

Prenatal Immune Challenge Disrupts Sensorimotor Gating in Adult Rats: Implications for the Etiopathogenesis of Schizophrenia

Antidepressive-like Behavior-Related Metabolomic Signatures of Sigma-1 Receptor Knockout Mice

Potentiation of Morphine Analgesia by Adjuvant Activation of 5-HT7 Receptors

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