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The use of Toll-like receptor 7/8 agonists as vaccine adjuvants

Expert review of vaccines, 2013-07, Vol.12 (7), p.809-819

2013

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Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'

Nature (London), 2011-04, Vol.472 (7344), p.471-475

2011

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Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation

The Journal of immunology (1950), 2014-11, Vol.193 (9), p.4722-4731

2014

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Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies

Journal for immunotherapy of cancer, 2019-09, Vol.7 (1), p.244-244, Article 244

2019

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Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8

The Journal of immunology (1950), 2005-02, Vol.174 (3), p.1259-1268

2005

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Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides

The Journal of immunology (1950), 2006-11, Vol.177 (10), p.6584-6587

2006

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First in Human Phase I Trial of 852A, a Novel Systemic Toll-like Receptor 7 Agonist, to Activate Innate Immune Responses in Patients with Advanced Cancer

Clinical cancer research, 2007-12, Vol.13 (23), p.7119-7125

2007

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TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth

JCI insight, 2017-03, Vol.2 (6), p.e91020-e91020

2017

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Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists

International immunology, 2006-07, Vol.18 (7), p.1115-1126

2006

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Comparison of human B cell activation by TLR7 and TLR9 agonists

BMC immunology, 2008-07, Vol.9 (1), p.39-39

2008

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Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors

Journal for immunotherapy of cancer, 2014-05, Vol.2 (1), p.12-12

2014

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Binding of Soluble Yeast β-Glucan to Human Neutrophils and Monocytes is Complement-Dependent

Frontiers in immunology, 2013, Vol.4, p.230-230

2013

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Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists

BMC immunology, 2007-10, Vol.8 (1), p.26-26

2007

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Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells

Journal of translational medicine, 2007-01, Vol.5 (1), p.5-5, Article 5

2007

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Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity

The Journal of immunology (1950), 2015-03, Vol.194 (6), p.2786-2795

2015

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Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with high-risk melanoma

Cancer immunology research, 2015-03, Vol.3 (3), p.278-287

2015

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TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN

Journal of interferon & cytokine research, 2008-04, Vol.28 (4), p.253-263

2008

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Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination

The Journal of biological chemistry, 2016-02, Vol.291 (8), p.3895-3904

2016

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Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN

The Journal of experimental medicine, 2004-03, Vol.199 (6), p.775-784

2004

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TLR-7 and -8 agonists as vaccine adjuvants

Expert review of vaccines, 2011-04, Vol.10 (4), p.405-407

2011

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Differential regulation of oxidative burst by distinct β-glucan-binding receptors and signaling pathways in human peripheral blood mononuclear cells

Glycobiology (Oxford), 2014-04, Vol.24 (4), p.379-391

2014

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Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod

Cellular immunology, 2002-07, Vol.218 (1), p.74-86

2002

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Oligodeoxynucleotides Differentially Modulate Activation of TLR7 and TLR8 by Imidazoquinolines

Journal of Immunology, 2006-12, Vol.177 (11), p.8164-8170

2006

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Resiquimod and other immune response modifiers as vaccine adjuvants

Expert review of vaccines, 2007-10, Vol.6 (5), p.835-847

2007

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Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats

Antiviral research, 2007-01, Vol.73 (1), p.1-11

2007

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The use of Toll-like receptor 7/8 agonists as vaccine adjuvants

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'

Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation

Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies

Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8

Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides

First in Human Phase I Trial of 852A, a Novel Systemic Toll-like Receptor 7 Agonist, to Activate Innate Immune Responses in Patients with Advanced Cancer

TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth

Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists

Comparison of human B cell activation by TLR7 and TLR9 agonists

Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors

Binding of Soluble Yeast β-Glucan to Human Neutrophils and Monocytes is Complement-Dependent

Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists

Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells

Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity

Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with high-risk melanoma

TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN

Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination

Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN

TLR-7 and -8 agonists as vaccine adjuvants

Differential regulation of oxidative burst by distinct β-glucan-binding receptors and signaling pathways in human peripheral blood mononuclear cells

Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod

Oligodeoxynucleotides Differentially Modulate Activation of TLR7 and TLR8 by Imidazoquinolines

Resiquimod and other immune response modifiers as vaccine adjuvants

Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats

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