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Gossypol: prototype of inhibitors targeted to dinucleotide folds

Current medicinal chemistry, 2000-04, Vol.7 (4), p.479-498

2000

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Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications

The Journal of biological chemistry, 1992-03, Vol.267 (7), p.4364-4369

1992

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Synthesis and Anti-HIV Activity of 1,1'-Dideoxygossypol and Related Compounds

Journal of medicinal chemistry, 1995-06, Vol.38 (13), p.2427-2432

1995

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Selective Inhibitors of Human Lactate Dehydrogenases and Lactate Dehydrogenase from the Malarial Parasite Plasmodium falciparum

Journal of medicinal chemistry, 1998-09, Vol.41 (20), p.3879-3887

1998

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Inactivation of glutathione reductase by 4-hydroxynonenal and other endogenous aldehydes

Biochemical pharmacology, 1997-04, Vol.53 (8), p.1133-1140

1997

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Aldose reductase from human skeletal and heart muscle. Interconvertible forms related by thiol-disulfide exchange

The Journal of biological chemistry, 1990-12, Vol.265 (34), p.20982-20987

1990

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Isolation and characterization of the multiple glutathione S-transferases from human liver. Evidence for unique heme-binding sites

The Journal of biological chemistry, 1985-09, Vol.260 (21), p.11603-11610

1985

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Glyoxalase II: molecular characteristics, kinetics and mechanism

Biochemical Society transactions, 1993-05, Vol.21 (2), p.522-527

Vander Jagt, D L

1993

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Characterization of a hemoglobin-degrading, low molecular weight protease from Plasmodium falciparum

Molecular and biochemical parasitology, 1986, Vol.18 (3), p.389-400

1986

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Aldose reductase-catalyzed reduction of acrolein: implications in cyclophosphamide toxicity

Molecular pharmacology, 1994-04, Vol.45 (4), p.797-801

1994

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Oxidative stress indices in IDDM subjects with and without long-term diabetic complications

Clinical biochemistry, 2001-06, Vol.34 (4), p.265-270

2001

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Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications

Chemico-biological interactions, 2001-01, Vol.130 (1-3), p.549-562

2001

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Increased levels of methylglyoxal-metabolizing enzymes in mononuclear and polymorphonuclear cells from insulin-dependent diabetic patients with diabetic complications: aldose reductase, glyoxalase I, and glyoxalase II--a clinical research center study

The journal of clinical endocrinology and metabolism, 1996-02, Vol.81 (2), p.488-492

1996

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NADPH Production by the Malarial Parasite Plasmodium Falciparum

Blood, 1989-07, Vol.74 (1), p.471-474

1989

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The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum

Molecular and biochemical parasitology, 2001-11, Vol.118 (1), p.23-32

2001

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Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum

Molecular and biochemical parasitology, 1997-12, Vol.90 (1), p.235-246

1997

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Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms

The Journal of biological chemistry, 1990-07, Vol.265 (19), p.10912-10918

1990

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Inhibition of human aldose and aldehyde reductases by non-steroidal anti-inflammatory drugs

Advances in experimental medicine and biology, 1999, Vol.463, p.493

1999

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Anti-oxidant activities of curcumin and related enones

Bioorganic & medicinal chemistry, 2005-06, Vol.13 (11), p.3811-3820

2005

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Homocysteine Increases the Expression of Vascular Endothelial Growth Factor by a Mechanism Involving Endoplasmic Reticulum Stress and Transcription Factor ATF4

The Journal of biological chemistry, 2004-04, Vol.279 (15), p.14844-14852

2004

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Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy

The journal of clinical endocrinology and metabolism, 1998-08, Vol.83 (8), p.2886-2891

1998

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3-Alkyl-6-Chloro-2-pyrones: Selective Inhibitors of Pancreatic Cholesterol Esterase

Journal of medicinal chemistry, 1999-10, Vol.42 (20), p.4250-4256

1999

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Comparative Structural Analysis and Kinetic Properties of Lactate Dehydrogenases from the Four Species of Human Malarial Parasites

Biochemistry (Easton), 2004-05, Vol.43 (20), p.6219-6229

2004

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2-Propylthiouracil does not replace glutathione for the glutathione transferases

The Journal of biological chemistry, 1984-06, Vol.259 (12), p.7409-7410

1984

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Inhibition of aldose reductase by gossypol and gossypol-related compounds

Advances in experimental medicine and biology, 1999, Vol.463, p.487

1999

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Gossypol: prototype of inhibitors targeted to dinucleotide folds

Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications

Synthesis and Anti-HIV Activity of 1,1'-Dideoxygossypol and Related Compounds

Selective Inhibitors of Human Lactate Dehydrogenases and Lactate Dehydrogenase from the Malarial Parasite Plasmodium falciparum

Inactivation of glutathione reductase by 4-hydroxynonenal and other endogenous aldehydes

Aldose reductase from human skeletal and heart muscle. Interconvertible forms related by thiol-disulfide exchange

Isolation and characterization of the multiple glutathione S-transferases from human liver. Evidence for unique heme-binding sites

Glyoxalase II: molecular characteristics, kinetics and mechanism

Characterization of a hemoglobin-degrading, low molecular weight protease from Plasmodium falciparum

Aldose reductase-catalyzed reduction of acrolein: implications in cyclophosphamide toxicity

Oxidative stress indices in IDDM subjects with and without long-term diabetic complications

Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications

Increased levels of methylglyoxal-metabolizing enzymes in mononuclear and polymorphonuclear cells from insulin-dependent diabetic patients with diabetic complications: aldose reductase, glyoxalase I, and glyoxalase II--a clinical research center study

NADPH Production by the Malarial Parasite Plasmodium Falciparum

The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum

Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum

Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms

Inhibition of human aldose and aldehyde reductases by non-steroidal anti-inflammatory drugs

Anti-oxidant activities of curcumin and related enones

Homocysteine Increases the Expression of Vascular Endothelial Growth Factor by a Mechanism Involving Endoplasmic Reticulum Stress and Transcription Factor ATF4

Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy

3-Alkyl-6-Chloro-2-pyrones: Selective Inhibitors of Pancreatic Cholesterol Esterase

Comparative Structural Analysis and Kinetic Properties of Lactate Dehydrogenases from the Four Species of Human Malarial Parasites

2-Propylthiouracil does not replace glutathione for the glutathione transferases

Inhibition of aldose reductase by gossypol and gossypol-related compounds

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