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Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

Biochemistry (Easton), 2009-05, Vol.48 (20), p.4331-4343

2009

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Reprogramming RNA processing: an emerging therapeutic landscape

Trends in pharmacological sciences (Regular ed.), 2022-05, Vol.43 (5), p.437-454

2022

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The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity

The Journal of biological chemistry, 2019-11, Vol.294 (45), p.16966-16977

2019

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Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication

Virology (New York, N.Y.), 2009-04, Vol.387 (1), p.5-10

2009

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Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket

Cell chemical biology, 2020-03, Vol.27 (3), p.259-268.e5

2020

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Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target

Journal of Virology, 2012-11, Vol.86 (21), p.11595-11607

2012

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Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1

ACS medicinal chemistry letters, 2020-06, Vol.11 (6), p.1305-1309

2020

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Nature's Inventory of Halogenation Catalysts: Oxidative Strategies Predominate

Chemical reviews, 2006-08, Vol.106 (8), p.3364-3378

2006

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The Ins and Outs of Ring-Cleaving Dioxygenases

Critical reviews in biochemistry and molecular biology, 2006-07, Vol.41 (4), p.241-267

2006

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Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis

Nature, 2006-03, Vol.440 (7082), p.368-371

2006

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Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

Nature, 2005-08, Vol.436 (7054), p.1191-1194

2005

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CmaE: A Transferase Shuttling Aminoacyl Groups between Carrier Protein Domains in the Coronamic Acid Biosynthetic Pathway

Biochemistry (Easton), 2007-06, Vol.46 (25), p.7549-7557

2007

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Halogenation of Unactivated Carbon Centers in Natural Product Biosynthesis: Trichlorination of Leucine during Barbamide Biosynthesis

Journal of the American Chemical Society, 2006-03, Vol.128 (12), p.3900-3901

2006

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Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3358-3368

2013

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Dichlorination and Bromination of a Threonyl‐ S ‐Carrier Protein by the Non‐heme Fe II Halogenase SyrB2

Chembiochem : a European journal of chemical biology, 2006-05, Vol.7 (5), p.748-752

2006

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Development and validation of a high-throughput screening assay for the hepatitis C virus p7 viroporin

Journal of biomolecular screening, 2011-03, Vol.16 (3), p.363-369

2011

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The Mechanism-based Inactivation of 2,3-Dihydroxybiphenyl 1,2-Dioxygenase by Catecholic Substrates

The Journal of biological chemistry, 2002-01, Vol.277 (3), p.2019-2027

2002

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Definitive Evidence for Monoanionic Binding of 2,3-Dihydroxybiphenyl to 2,3-Dihydroxybiphenyl 1,2-Dioxygenase from UV Resonance Raman Spectroscopy, UV/Vis Absorption Spectroscopy, and Crystallography

Journal of the American Chemical Society, 2002-03, Vol.124 (11), p.2485-2496

2002

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Characterization of Extradiol Dioxygenases from a Polychlorinated Biphenyl-Degrading Strain That Possess Higher Specificities for Chlorinated Metabolites

Journal of Bacteriology, 2003-02, Vol.185 (4), p.1253-1260

2003

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Identification and analysis of a bottleneck in PCB biodegradation

Nature structural & molecular biology, 2002-12, Vol.9 (12), p.934-939

2002

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Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer

Molecular cancer therapeutics, 2022-06, Vol.21 (6), p.890-902

2022

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SyrB2 in Syringomycin E Biosynthesis Is a Nonheme FeIIα-Ketoglutarate- and O2-Dependent Halogenase

Proceedings of the National Academy of Sciences - PNAS, 2005-07, Vol.102 (29), p.10111-10116

2005

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Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete

Chemistry & biology, 2006-11, Vol.13 (11), p.1183-1191

2006

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Reactivity of Toluate Dioxygenase with Substituted Benzoates and Dioxygen

Journal of Bacteriology, 2002-08, Vol.184 (15), p.4096-4103

2002

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Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα WT and ERα MUT Breast Cancer

Cancer discovery, 2018-09, Vol.8 (9), p.1176-1193

2018

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Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

Reprogramming RNA processing: an emerging therapeutic landscape

The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity

Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication

Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket

Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target

Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1

Nature's Inventory of Halogenation Catalysts: Oxidative Strategies Predominate

The Ins and Outs of Ring-Cleaving Dioxygenases

Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis

Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

CmaE: A Transferase Shuttling Aminoacyl Groups between Carrier Protein Domains in the Coronamic Acid Biosynthetic Pathway

Halogenation of Unactivated Carbon Centers in Natural Product Biosynthesis: Trichlorination of Leucine during Barbamide Biosynthesis

Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo

Dichlorination and Bromination of a Threonyl‐ S ‐Carrier Protein by the Non‐heme Fe II Halogenase SyrB2

Development and validation of a high-throughput screening assay for the hepatitis C virus p7 viroporin

The Mechanism-based Inactivation of 2,3-Dihydroxybiphenyl 1,2-Dioxygenase by Catecholic Substrates

Definitive Evidence for Monoanionic Binding of 2,3-Dihydroxybiphenyl to 2,3-Dihydroxybiphenyl 1,2-Dioxygenase from UV Resonance Raman Spectroscopy, UV/Vis Absorption Spectroscopy, and Crystallography

Characterization of Extradiol Dioxygenases from a Polychlorinated Biphenyl-Degrading Strain That Possess Higher Specificities for Chlorinated Metabolites

Identification and analysis of a bottleneck in PCB biodegradation

Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer

SyrB2 in Syringomycin E Biosynthesis Is a Nonheme FeIIα-Ketoglutarate- and O2-Dependent Halogenase

Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete

Reactivity of Toluate Dioxygenase with Substituted Benzoates and Dioxygen

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα WT and ERα MUT Breast Cancer

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