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The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

Behavioural brain research, 2016-04, Vol.303, p.26-33

2016

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An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients

Psychopharmacology, 2021-05, Vol.238 (5), p.1279-1289

2021

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A randomized, placebo-controlled, phase 1 study to evaluate the effects of TAK-063 on ketamine-induced changes in fMRI BOLD signal in healthy subjects

Psychopharmacology, 2020-02, Vol.237 (2), p.317-328

2020

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Phase 1 randomized study on the safety, tolerability, and pharmacodynamic cognitive and electrophysiological effects of a dopamine D1 receptor positive allosteric modulator in patients with schizophrenia

Neuropsychopharmacology (New York, N.Y.), 2021-05, Vol.46 (6), p.1145-1151

2021

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Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [ 11 C]PHNO PET

Neuropsychopharmacology (New York, N.Y.), 2022-06, Vol.47 (7), p.1405-1412

2022

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The effects of roflumilast, a phosphodiesterase type-4 inhibitor, on EEG biomarkers in schizophrenia: A randomised controlled trial

Journal of psychopharmacology (Oxford), 2021-01, Vol.35 (1), p.15-22

2021

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Role of melatonin receptors in the effects of melatonin on BDNF and neuroprotection in mouse cerebellar neurons

Journal of Neural Transmission, 2008-11, Vol.115 (11), p.1495-1499

2008

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Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice

Neuroscience letters, 2006-01, Vol.393 (1), p.23-26

2006

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Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro

European journal of pharmacology, 2001-01, Vol.411 (1-2), p.67-70

2001

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Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice

Neuroscience letters, 2008-05, Vol.436 (2), p.269-272

2008

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Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors

Neuroscience letters, 2008-12, Vol.447 (2-3), p.134-137

2008

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Diurnal rhythms in quinpirole-induced locomotor behaviors and striatal D2/D3 receptor levels in mice

Pharmacology, biochemistry and behavior, 2005-03, Vol.80 (3), p.371-377

2005

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Glia as a putative target for antidepressant treatments

Journal of affective disorders, 2003-06, Vol.75 (1), p.59-64

2003

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The pattern of melatonin receptor expression in the brain may influence antidepressant treatment

Medical hypotheses, 2007-01, Vol.69 (1), p.120-124

2007

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Aging‐associated up‐regulation of neuronal 5‐lipoxygenase expression: putative role in neuronal vulnerability

The FASEB journal, 1998-04, Vol.12 (6), p.439-449

1998

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The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system

Brain research. Molecular brain research., 2005-05, Vol.136 (1), p.45-53

2005

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Neuronal expression of arylalkylamine N-acetyltransferase (AANAT) mRNA in the rat brain

Neuroscience research, 2002-04, Vol.42 (4), p.309-316

2002

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Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Doses of TAK-935 in Healthy Subjects (P5.267)

Neurology, 2018-04, Vol.90 (15_supplement)

2018

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Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of TAK-935 in Healthy Subjects (P5.262)

Neurology, 2018-04, Vol.90 (15_supplement)

2018

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Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study

Neurobiology of aging, 2019-05, Vol.77, p.37-43

2019

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Phase 1 randomized study on the safety, tolerability, and pharmacodynamic cognitive and electrophysiological effects of a dopamine D 1 receptor positive allosteric modulator in patients with schizophrenia

Neuropsychopharmacology (New York, N.Y.), 2021-05, Vol.46 (6), p.1145

2021

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Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus

Neuroreport, 2003-08, Vol.14 (11), p.1471-1473

2003

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Pharmacokinetics of ASP4345 from Single Ascending-Dose and Multiple Ascending-Dose Phase I Studies

Clinical pharmacokinetics, 2021-01, Vol.60 (1), p.79-88

2021

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Characterization of Zinc-Induced Neuronal Death in Primary Cultures of Rat Cerebellar Granule Cells

Experimental neurology, 1997-07, Vol.146 (1), p.171-178

1997

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Single‐ and multiple‐dose safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of ASP0367, or bocidelpar sulfate, a novel modulator of peroxisome proliferator‐activated receptor delta in healthy adults: Results from a phase 1 study

Muscle & nerve, 2022-01, Vol.65 (1), p.110-120

2022

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The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients

A randomized, placebo-controlled, phase 1 study to evaluate the effects of TAK-063 on ketamine-induced changes in fMRI BOLD signal in healthy subjects

Phase 1 randomized study on the safety, tolerability, and pharmacodynamic cognitive and electrophysiological effects of a dopamine D1 receptor positive allosteric modulator in patients with schizophrenia

Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [ 11 C]PHNO PET

The effects of roflumilast, a phosphodiesterase type-4 inhibitor, on EEG biomarkers in schizophrenia: A randomised controlled trial

Role of melatonin receptors in the effects of melatonin on BDNF and neuroprotection in mouse cerebellar neurons

Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice

Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro

Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice

Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors

Diurnal rhythms in quinpirole-induced locomotor behaviors and striatal D2/D3 receptor levels in mice

Glia as a putative target for antidepressant treatments

The pattern of melatonin receptor expression in the brain may influence antidepressant treatment

Aging‐associated up‐regulation of neuronal 5‐lipoxygenase expression: putative role in neuronal vulnerability

The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system

Neuronal expression of arylalkylamine N-acetyltransferase (AANAT) mRNA in the rat brain

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Doses of TAK-935 in Healthy Subjects (P5.267)

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of TAK-935 in Healthy Subjects (P5.262)

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study

Phase 1 randomized study on the safety, tolerability, and pharmacodynamic cognitive and electrophysiological effects of a dopamine D 1 receptor positive allosteric modulator in patients with schizophrenia

Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus

Pharmacokinetics of ASP4345 from Single Ascending-Dose and Multiple Ascending-Dose Phase I Studies

Characterization of Zinc-Induced Neuronal Death in Primary Cultures of Rat Cerebellar Granule Cells

Single‐ and multiple‐dose safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of ASP0367, or bocidelpar sulfate, a novel modulator of peroxisome proliferator‐activated receptor delta in healthy adults: Results from a phase 1 study

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