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1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology

Current pharmaceutical design, 2016-01, Vol.22 (21), p.3201-3211

Uto, Yoshikazu

2016

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Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors

Chemistry and physics of lipids, 2016-05, Vol.197, p.3-12

Uto, Yoshikazu

2016

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A Novel Inhibitor of Stearoyl-CoA Desaturase-1 Attenuates Hepatic Lipid Accumulation, Liver Injury and Inflammation in Model of Nonalcoholic Steatohepatitis

Biological and Pharmaceutical Bulletin, 2013/02/01, Vol.36(2), pp.259-267

2013

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Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015)

Expert opinion on therapeutic patents, 2016-03, Vol.26 (3), p.309-322

2016

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Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010)

Expert opinion on therapeutic patents, 2011-02, Vol.21 (2), p.131-146

2011

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1,2-Benzisoxazole compounds: a patent review (2009 - 2014)

Expert opinion on therapeutic patents, 2015-06, Vol.25 (6), p.643-662

Uto, Yoshikazu

2015

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Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020)

Expert opinion on therapeutic patents, 2021-05, Vol.31 (5), p.387-397

2021

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Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676)

Expert opinion on therapeutic patents, 2015-03, Vol.25 (3), p.373-377

Uto, Yoshikazu

2015

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Total Synthesis and Revision of Stereochemistry of the Marine Metabolite Trunkamide A

Journal of organic chemistry, 2000-02, Vol.65 (4), p.1037-1049

2000

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Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4159-4166

2009

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Total Synthesis of a Stereoisomer of Bistramide C and Assignment of Configuration of the Natural Product

Chemistry : a European journal, 2002-04, Vol.8 (7), p.1670-1681

2002

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Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4151-4158

2009

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Benzisoxazole analogs as glycogen synthase activators, a patent evaluation (WO2011057956)

Expert opinion on therapeutic patents, 2012-06, Vol.22 (6), p.701-707

Uto, Yoshikazu

2012

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Piperidine and pyrrolidine analogs as glycogen synthase activators; a patent evaluation (WO2011058122)

Expert opinion on therapeutic patents, 2012-01, Vol.22 (1), p.89-93

Uto, Yoshikazu

2012

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Synthesis of Functionalized Oxazolines and Oxazoles with DAST and Deoxo-Fluor

Organic letters, 2000-04, Vol.2 (8), p.1165-1168

2000

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Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3H-spiro [1,5-benzoxazepine-2,4'-piperidine] analogs

European journal of medicinal chemistry, 2011-05, Vol.46 (5), p.1892-1896

2011

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Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4′-piperidine] analogs

European journal of medicinal chemistry, 2010-11, Vol.45 (11), p.4788-4796

2010

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Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.341-345

2010

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Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine]

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.746-754

2010

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Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3 H-spiro[1,5-benzoxazepine-2,4′-piperidine] analogs

European journal of medicinal chemistry, 2011, Vol.46 (5), p.1892-1896

2011

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Total synthesis of the putative structure of the marine metabolite trunkamide A

Tetrahedron letters, 1999-07, Vol.40 (28), p.5165-5169

1999

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Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2- hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamid e and its biological evaluation

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4159-4166

2009

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Synthesis of Functionalized Oxazolines and Oxazoles with DAST and Deoxo-Fluor

Organic letters, 2002-12, Vol.4 (26), p.4743-4743

2002

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Studies toward the total synthesis and stereochemical assignment of Lissoclinum metabolites: Trunkamide A and bistramide C

Uto, Yoshikazu

2001

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ChemInform Abstract: Novel Spiropiperidine-Based Stearoyl-CoA Desaturase-1 Inhibitors: Identification of 1′-{6-[5-(Pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl] pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro [chromene-2,4′-piperidine]

ChemInform, 2010-06, Vol.41 (24), p.no-no

2010

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1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology

Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors

A Novel Inhibitor of Stearoyl-CoA Desaturase-1 Attenuates Hepatic Lipid Accumulation, Liver Injury and Inflammation in Model of Nonalcoholic Steatohepatitis

Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015)

Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010)

1,2-Benzisoxazole compounds: a patent review (2009 - 2014)

Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020)

Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676)

Total Synthesis and Revision of Stereochemistry of the Marine Metabolite Trunkamide A

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation

Total Synthesis of a Stereoisomer of Bistramide C and Assignment of Configuration of the Natural Product

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide

Benzisoxazole analogs as glycogen synthase activators, a patent evaluation (WO2011057956)

Piperidine and pyrrolidine analogs as glycogen synthase activators; a patent evaluation (WO2011058122)

Synthesis of Functionalized Oxazolines and Oxazoles with DAST and Deoxo-Fluor

Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3H-spiro [1,5-benzoxazepine-2,4'-piperidine] analogs

Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4′-piperidine] analogs

Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats

Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine]

Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3 H-spiro[1,5-benzoxazepine-2,4′-piperidine] analogs

Total synthesis of the putative structure of the marine metabolite trunkamide A

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2- hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamid e and its biological evaluation

Synthesis of Functionalized Oxazolines and Oxazoles with DAST and Deoxo-Fluor

Studies toward the total synthesis and stereochemical assignment of Lissoclinum metabolites: Trunkamide A and bistramide C

ChemInform Abstract: Novel Spiropiperidine-Based Stearoyl-CoA Desaturase-1 Inhibitors: Identification of 1′-{6-[5-(Pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl] pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro [chromene-2,4′-piperidine]

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