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Recombinant protein production‐associated metabolic burden reflects anabolic constraints and reveals similarities to a carbon overfeeding response

Biotechnology and bioengineering, 2021-01, Vol.118 (1), p.94-105

2021

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Recombinant protein production associated growth inhibition results mainly from transcription and not from translation

Microbial cell factories, 2020-04, Vol.19 (1), p.83-83, Article 83

2020

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Counting young birds: A simple tool for the determination of avian population parameters

PloS one, 2023-02, Vol.18 (2), p.e0279899-e0279899

2023

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Is energy excess the initial trigger of carbon overflow metabolism? Transcriptional network response of carbon-limited Escherichia coli to transient carbon excess

Microbial cell factories, 2022-04, Vol.21 (1), p.67-67, Article 67

2022

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Recombinant protein production provoked accumulation of ATP, fructose-1,6-bisphosphate and pyruvate in E. coli K12 strain TG1

Microbial cell factories, 2021-08, Vol.20 (1), p.169-169, Article 169

2021

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Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress

Cardiovascular research, 2014-03, Vol.101 (4), p.587-596

2014

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Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview

Microbial cell factories, 2008-04, Vol.7 (1), p.11-11, Article 11

2008

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Strategies for the recovery of active proteins through refolding of bacterial inclusion body proteins

Microbial cell factories, 2004-09, Vol.3 (1), p.11-11

2004

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The effect of an rhBMP-2 absorbable collagen sponge-targeted system on bone formation in vivo

Biomaterials, 2009-04, Vol.30 (11), p.2032-2037

2009

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Side effects of chaperone gene co-expression in recombinant protein production

Microbial cell factories, 2010-09, Vol.9 (1), p.64-64, Article 64

2010

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Stress induced by recombinant protein production in Escherichia coli

Advances in biochemical engineering, biotechnology, 2004, Vol.89, p.73

2004

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Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes

Microbial cell factories, 2012-08, Vol.11 (1), p.103-103, Article 103

2012

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Fate of the UPR marker protein Kar2/Bip and autophagic processes in fed-batch cultures of secretory insulin precursor producing Pichia pastoris

Microbial cell factories, 2018-08, Vol.17 (1), p.123-123, Article 123

2018

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Metabolic flux analysis of Escherichia coli in glucose-limited continuous culture. I. Growth-rate-dependent metabolic efficiency at steady state

Microbiology (Society for General Microbiology), 2005-03, Vol.151 (Pt 3), p.693

2005

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The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate

Microbial cell factories, 2010-04, Vol.9 (1), p.23-23, Article 23

2010

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Transcriptional network analysis identifies key elements governing the recombinant protein production provoked reprogramming of carbon and energy metabolism in Escherichia coli BL21 (DE3)

Engineering reports (Hoboken, N.J.), 2021-09, Vol.3 (9), p.n/a

2021

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Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells

Cell biology international, 2016-05, Vol.40 (5), p.534-548

2016

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Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies

Advanced science, 2019-09, Vol.6 (18), p.1900849-n/a

2019

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Packaging protein drugs as bacterial inclusion bodies for therapeutic applications

Microbial cell factories, 2012-06, Vol.11 (1), p.76-76

2012

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Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin

Microbial cell factories, 2010-05, Vol.9 (1), p.31-31, Article 31

2010

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Agitation effects on morphology and protein productive fractions of filamentous and pelleted growth forms of recombinant Aspergillus niger

Process biochemistry (1991), 2006-10, Vol.41 (10), p.2103-2112

2006

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Inclusion body anatomy and functioning of chaperone-mediated in vivo inclusion body disassembly during high-level recombinant protein production in Escherichia coli

Journal of biotechnology, 2007, Vol.127 (2), p.244-257

2007

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Simple high-cell density fed-batch technique for high-level recombinant protein production with Pichia pastoris: Application to intracellular production of Hepatitis B surface antigen

Microbial cell factories, 2009-02, Vol.8 (1), p.13-13, Article 13

2009

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Optimized procedure for renaturation of recombinant human bone morphogenetic protein-2 at high protein concentration

Biotechnology and bioengineering, 2004-03, Vol.85 (6), p.601-609

2004

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Environment matters - An E. coli case study. How process technology affects cell physiology and product quality/quantity

Microbial cell factories, 2006-10, Vol.5 Suppl 1 (Suppl 1), p.S12-S12

Rinas, Ursula

2006

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Recombinant protein production‐associated metabolic burden reflects anabolic constraints and reveals similarities to a carbon overfeeding response

Recombinant protein production associated growth inhibition results mainly from transcription and not from translation

Counting young birds: A simple tool for the determination of avian population parameters

Is energy excess the initial trigger of carbon overflow metabolism? Transcriptional network response of carbon-limited Escherichia coli to transient carbon excess

Recombinant protein production provoked accumulation of ATP, fructose-1,6-bisphosphate and pyruvate in E. coli K12 strain TG1

Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress

Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview

Strategies for the recovery of active proteins through refolding of bacterial inclusion body proteins

The effect of an rhBMP-2 absorbable collagen sponge-targeted system on bone formation in vivo

Side effects of chaperone gene co-expression in recombinant protein production

Stress induced by recombinant protein production in Escherichia coli

Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes

Fate of the UPR marker protein Kar2/Bip and autophagic processes in fed-batch cultures of secretory insulin precursor producing Pichia pastoris

Metabolic flux analysis of Escherichia coli in glucose-limited continuous culture. I. Growth-rate-dependent metabolic efficiency at steady state

The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate

Transcriptional network analysis identifies key elements governing the recombinant protein production provoked reprogramming of carbon and energy metabolism in Escherichia coli BL21 (DE3)

Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells

Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies

Packaging protein drugs as bacterial inclusion bodies for therapeutic applications

Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin

Agitation effects on morphology and protein productive fractions of filamentous and pelleted growth forms of recombinant Aspergillus niger

Inclusion body anatomy and functioning of chaperone-mediated in vivo inclusion body disassembly during high-level recombinant protein production in Escherichia coli

Simple high-cell density fed-batch technique for high-level recombinant protein production with Pichia pastoris: Application to intracellular production of Hepatitis B surface antigen

Optimized procedure for renaturation of recombinant human bone morphogenetic protein-2 at high protein concentration

Environment matters - An E. coli case study. How process technology affects cell physiology and product quality/quantity

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