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Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH

PloS one, 2024-04, Vol.19 (4), p.e0301711-e0301711

2024

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Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model

PloS one, 2024-03, Vol.19 (3), p.e0298211-e0298211

2024

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The cyclophilin inhibitor CRV431 inhibits liver HBV DNA and HBsAg in transgenic mice

PloS one, 2019-06, Vol.14 (6), p.e0217433-e0217433

2019

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A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models

The Journal of pharmacology and experimental therapeutics, 2019-11, Vol.371 (2), p.231

2019

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Structurally distinct cyclosporin and sanglifehrin analogs CRV431 and NV556 suppress established HCV infection in humanized-liver mice

PloS one, 2020-08, Vol.15 (8), p.e0237236-e0237236

2020

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The Cyclophilin Inhibitor Rencofilstat Decreases HCV-Induced Hepatocellular Carcinoma Independently of Its Antiviral Activity

Viruses, 2023-10, Vol.15 (10), p.2099

2023

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Cyclophilin inhibition as a potential treatment for nonalcoholic steatohepatitis (NASH)

Expert opinion on investigational drugs, 2020-02, Vol.29 (2), p.163-178

2020

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Differential Effects of Voclosporin and Tacrolimus on Insulin Secretion From Human Islets

Endocrinology (Philadelphia), 2020-11, Vol.161 (11), p.1

2020

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Development, Characterization, and Pharmacokinetic Evaluation of a CRV431 Loaded Self-Microemulsifying Drug Delivery System

Journal of pharmacy & pharmaceutical sciences, 2018-01, Vol.21 (1s), p.335s

2018

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The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance

PloS one, 2021-05, Vol.16 (5), p.e0251934-e0251934

2021

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In Vitro Phase I Metabolism of CRV431, a Novel Oral Drug Candidate for Chronic Hepatitis B

Pharmaceutics, 2017-11, Vol.9 (4), p.51

2017

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Rencofilstat, a cyclophilin inhibitor: A phase 2a, multicenter, single‐blind, placebo‐controlled study in F2/F3 NASH

Hepatology communications, 2022-12, Vol.6 (12), p.3379-3392

2022

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The Novel Cyclophilin Inhibitor CPI-431-32 Concurrently Blocks HCV and HIV-1 Infections via a Similar Mechanism of Action

PloS one, 2015-08, Vol.10 (8), p.e0134707

2015

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Polyreactive antibodies to glatiramer acetate promote myelin repair in murine model of demyelinating disease

The FASEB journal, 2002-08, Vol.16 (10), p.1260-1262

2002

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Mice lacking Cyclophilin B, but not Cyclophilin A, are significantly protected from the development of major features of NAFLD/NASH in a diet and chemical-induced model

Journal of hepatology, 2023-06, Vol.78, p.S748

2023

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WED-420 - Mice lacking Cyclophilin B, but not Cyclophilin A, are significantly protected from the development of major features of NAFLD/NASH in a diet and chemical-induced model

Journal of hepatology, 2023-06, Vol.78, p.S748-S748

2023

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Cyclophilin D knockout promotes cell death pathways in preventing HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH

Journal of hepatology, 2022-07, Vol.77, p.S650

2022

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Cyclophilin inhibition with rencofilstat shifts the liver transcriptome and lipidome in preclinical models toward resolution of non-alcoholic steatohepatitis

Journal of hepatology, 2023-06, Vol.78, p.S770

2023

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WED-455 - Cyclophilin inhibition with rencofilstat shifts the liver transcriptome and lipidome in preclinical models toward resolution of non-alcoholic steatohepatitis

Journal of hepatology, 2023-06, Vol.78, p.S770-S770

2023

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Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells

The Journal of immunology (1950), 2010-06, Vol.184 (11), p.6552-6552

2010

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Rencofilstat, a pan-cyclophilin inhibitor, exerts diverse metabolic and transcriptional anti-tumor activities in a murine NASH-HCC model

Journal of hepatology, 2022-07, Vol.77, p.S660

2022

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Integrated transcriptomics of CRV431 treatment in a Phase 2a NASH trial confirms anti-fibrotic effect of pan-cyclophilin inhibition and identifies CRV431-specific biomarkers

Journal of hepatology, 2022-07, Vol.77, p.S726-S727

2022

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Synergistic anti-tumor activity with a combination of anti-PD1 antibody and the cyclophilin inhibitor, rencofilstat, in the Hep53.4 fatty liver model of hepatocellular carcinoma

Journal of hepatology, 2022-07, Vol.77, p.S660

2022

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Genetically Dominant Spinal Cord Repair in a Murine Model of Chronic Progressive Multiple Sclerosis

Journal of neuropathology and experimental neurology, 2005-01, Vol.64 (1), p.46-57

2005

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Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler's virus infection

International immunology, 2005-05, Vol.17 (5), p.569-579

2005

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Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH

Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model

The cyclophilin inhibitor CRV431 inhibits liver HBV DNA and HBsAg in transgenic mice

A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models

Structurally distinct cyclosporin and sanglifehrin analogs CRV431 and NV556 suppress established HCV infection in humanized-liver mice

The Cyclophilin Inhibitor Rencofilstat Decreases HCV-Induced Hepatocellular Carcinoma Independently of Its Antiviral Activity

Cyclophilin inhibition as a potential treatment for nonalcoholic steatohepatitis (NASH)

Differential Effects of Voclosporin and Tacrolimus on Insulin Secretion From Human Islets

Development, Characterization, and Pharmacokinetic Evaluation of a CRV431 Loaded Self-Microemulsifying Drug Delivery System

The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance

In Vitro Phase I Metabolism of CRV431, a Novel Oral Drug Candidate for Chronic Hepatitis B

Rencofilstat, a cyclophilin inhibitor: A phase 2a, multicenter, single‐blind, placebo‐controlled study in F2/F3 NASH

The Novel Cyclophilin Inhibitor CPI-431-32 Concurrently Blocks HCV and HIV-1 Infections via a Similar Mechanism of Action

Polyreactive antibodies to glatiramer acetate promote myelin repair in murine model of demyelinating disease

Mice lacking Cyclophilin B, but not Cyclophilin A, are significantly protected from the development of major features of NAFLD/NASH in a diet and chemical-induced model

WED-420 - Mice lacking Cyclophilin B, but not Cyclophilin A, are significantly protected from the development of major features of NAFLD/NASH in a diet and chemical-induced model

Cyclophilin D knockout promotes cell death pathways in preventing HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH

Cyclophilin inhibition with rencofilstat shifts the liver transcriptome and lipidome in preclinical models toward resolution of non-alcoholic steatohepatitis

WED-455 - Cyclophilin inhibition with rencofilstat shifts the liver transcriptome and lipidome in preclinical models toward resolution of non-alcoholic steatohepatitis

Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells

Rencofilstat, a pan-cyclophilin inhibitor, exerts diverse metabolic and transcriptional anti-tumor activities in a murine NASH-HCC model

Integrated transcriptomics of CRV431 treatment in a Phase 2a NASH trial confirms anti-fibrotic effect of pan-cyclophilin inhibition and identifies CRV431-specific biomarkers

Synergistic anti-tumor activity with a combination of anti-PD1 antibody and the cyclophilin inhibitor, rencofilstat, in the Hep53.4 fatty liver model of hepatocellular carcinoma

Genetically Dominant Spinal Cord Repair in a Murine Model of Chronic Progressive Multiple Sclerosis

Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler's virus infection

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