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Novel live imaging techniques of cellular functions and in vivo tumors based on precise design of small molecule-based ‘Activatable’ fluorescence probes

Current opinion in chemical biology, 2012-12, Vol.16 (5-6), p.602-608

Urano, Yasuteru

2012

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N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production

Cell chemical biology, 2018-04, Vol.25 (4), p.447-459.e4

2018

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A Reversible Fluorescent Probe for Real‐Time Live‐Cell Imaging and Quantification of Endogenous Hydropolysulfides

Angewandte Chemie (International ed.), 2018-07, Vol.57 (30), p.9346-9350

International ed. in English, 2018

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Multicolor Activatable Raman Probes for Simultaneous Detection of Plural Enzyme Activities

Journal of the American Chemical Society, 2020-12, Vol.142 (49), p.20701-20707

2020

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Development of an Iminocoumarin-Based Zinc Sensor Suitable for Ratiometric Fluorescence Imaging of Neuronal Zinc

Journal of the American Chemical Society, 2007-11, Vol.129 (44), p.13447-13454

2007

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Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy

Journal of the American Chemical Society, 2017-10, Vol.139 (39), p.13713-13719

2017

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Design and Synthesis of a Library of BODIPY-Based Environmental Polarity Sensors Utilizing Photoinduced Electron-Transfer-Controlled Fluorescence ON/OFF Switching

Journal of the American Chemical Society, 2007-05, Vol.129 (17), p.5597-5604

2007

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Evolution of Group 14 Rhodamines as Platforms for Near-Infrared Fluorescence Probes Utilizing Photoinduced Electron Transfer

ACS chemical biology, 2011-06, Vol.6 (6), p.600-608

2011

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Asymmetric Rhodamine-Based Fluorescent Probe for Multicolour In Vivo Imaging

Chemistry : a European journal, 2016-01, Vol.22 (5), p.1696-1703

2016

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Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging

Journal of the American Chemical Society, 2020-05, Vol.142 (21), p.9625-9633, Article jacs.0c00451

2020

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Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

Nature medicine, 2018-02, Vol.24 (2), p.232-238

2018

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Enzyme-Loaded Polyion Complex Vesicles as in Vivo Nanoreactors Working Sustainably under the Blood Circulation: Characterization and Functional Evaluation

Biomacromolecules, 2017-04, Vol.18 (4), p.1189-1196

2017

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Recent Progress in Small Spirocyclic, Xanthene-Based Fluorescent Probes

Molecules (Basel, Switzerland), 2020-12, Vol.25 (24), p.5964

2020

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Development and Application of a Near-Infrared Fluorescence Probe for Oxidative Stress Based on Differential Reactivity of Linked Cyanine Dyes

Journal of the American Chemical Society, 2010-03, Vol.132 (8), p.2795-2801

2010

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Fluorescence Detection of Prostate Cancer by an Activatable Fluorescence Probe for PSMA Carboxypeptidase Activity

Journal of the American Chemical Society, 2019-07, Vol.141 (26), p.10409-10416

2019

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Mechanism-Based Molecular Design of Highly Selective Fluorescence Probes for Nitrative Stress

Journal of the American Chemical Society, 2006-08, Vol.128 (33), p.10640-10641

2006

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A spontaneously blinking fluorophore based on intramolecular spirocyclization for live-cell super-resolution imaging

Nature chemistry, 2014-08, Vol.6 (8), p.681

2014

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Development of a Ratiometric Fluorescent Zinc Ion Probe in Near-Infrared Region, Based on Tricarbocyanine Chromophore

Journal of the American Chemical Society, 2006-05, Vol.128 (20), p.6548-6549

2006

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Design of Photostable, Activatable Near‐Infrared Photoacoustic Probes Using Tautomeric Benziphthalocyanine as a Platform

Angewandte Chemie (International ed.), 2019-06, Vol.58 (23), p.7788-7791

International ed. in English, 2019

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Development of a Series of Practical Fluorescent Chemical Tools To Measure pH Values in Living Samples

Journal of the American Chemical Society, 2018-05, Vol.140 (18), p.5925-5933

2018

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Rational Design of Highly Sensitive Fluorescence Probes for Protease and Glycosidase Based on Precisely Controlled Spirocyclization

Journal of the American Chemical Society, 2013-01, Vol.135 (1), p.409-414

2013

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Evaluation of Enzymatic Activities in Living Systems with Small-molecular Fluorescent Substrate Probes

Analytical Sciences, 2015/04/10, Vol.31(4), pp.257-265

2015

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Development of a Highly Specific Rhodamine-Based Fluorescence Probe for Hypochlorous Acid and Its Application to Real-Time Imaging of Phagocytosis

Journal of the American Chemical Society, 2007-06, Vol.129 (23), p.7313-7318

2007

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Polysulfides (H 2 S n ) produced from the interaction of hydrogen sulfide (H 2 S) and nitric oxide (NO) activate TRPA1 channels

Scientific reports, 2017-04, Vol.7 (1), p.45995-45995, Article 45995

2017

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General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process

Journal of the American Chemical Society, 2022-11, Vol.144 (43), p.19778-19790

2022

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Novel live imaging techniques of cellular functions and in vivo tumors based on precise design of small molecule-based ‘Activatable’ fluorescence probes

N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production

A Reversible Fluorescent Probe for Real‐Time Live‐Cell Imaging and Quantification of Endogenous Hydropolysulfides

Multicolor Activatable Raman Probes for Simultaneous Detection of Plural Enzyme Activities

Development of an Iminocoumarin-Based Zinc Sensor Suitable for Ratiometric Fluorescence Imaging of Neuronal Zinc

Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy

Design and Synthesis of a Library of BODIPY-Based Environmental Polarity Sensors Utilizing Photoinduced Electron-Transfer-Controlled Fluorescence ON/OFF Switching

Evolution of Group 14 Rhodamines as Platforms for Near-Infrared Fluorescence Probes Utilizing Photoinduced Electron Transfer

Asymmetric Rhodamine-Based Fluorescent Probe for Multicolour In Vivo Imaging

Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

Enzyme-Loaded Polyion Complex Vesicles as in Vivo Nanoreactors Working Sustainably under the Blood Circulation: Characterization and Functional Evaluation

Recent Progress in Small Spirocyclic, Xanthene-Based Fluorescent Probes

Development and Application of a Near-Infrared Fluorescence Probe for Oxidative Stress Based on Differential Reactivity of Linked Cyanine Dyes

Fluorescence Detection of Prostate Cancer by an Activatable Fluorescence Probe for PSMA Carboxypeptidase Activity

Mechanism-Based Molecular Design of Highly Selective Fluorescence Probes for Nitrative Stress

A spontaneously blinking fluorophore based on intramolecular spirocyclization for live-cell super-resolution imaging

Development of a Ratiometric Fluorescent Zinc Ion Probe in Near-Infrared Region, Based on Tricarbocyanine Chromophore

Design of Photostable, Activatable Near‐Infrared Photoacoustic Probes Using Tautomeric Benziphthalocyanine as a Platform

Development of a Series of Practical Fluorescent Chemical Tools To Measure pH Values in Living Samples

Rational Design of Highly Sensitive Fluorescence Probes for Protease and Glycosidase Based on Precisely Controlled Spirocyclization

Evaluation of Enzymatic Activities in Living Systems with Small-molecular Fluorescent Substrate Probes

Development of a Highly Specific Rhodamine-Based Fluorescence Probe for Hypochlorous Acid and Its Application to Real-Time Imaging of Phagocytosis

Polysulfides (H 2 S n ) produced from the interaction of hydrogen sulfide (H 2 S) and nitric oxide (NO) activate TRPA1 channels

General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process

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