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BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS

Biotechnology advances, 2015-03, Vol.33 (2), p.277-287

2015

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A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models

Haematologica (Roma), 2020-03, Vol.105 (3), p.741

2020

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CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma

Journal of experimental & clinical cancer research, 2022-02, Vol.41 (1), p.49-17, Article 49

2022

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Selective depletion of metastatic stem cells as therapy for human colorectal cancer

EMBO molecular medicine, 2018-10, Vol.10 (10), p.n/a

2018

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GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases

Drug delivery, 2022-12, Vol.29 (1), p.1384-1397

2022

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Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles

Biomedicine & pharmacotherapy, 2023-08, Vol.164, p.114976-114976, Article 114976

2023

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An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

Journal of hematology and oncology, 2020-04, Vol.13 (1), p.36-19, Article 36

2020

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An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials

International journal of molecular sciences, 2022-04, Vol.23 (9), p.4958

2022

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Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models

Cancers, 2022-12, Vol.15 (1), p.85

2022

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Ion-dependent slow protein release from in vivo disintegrating micro-granules

Drug delivery, 2021-01, Vol.28 (1), p.2383-2391

2021

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A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice

Biomedicine & pharmacotherapy, 2022-06, Vol.150, p.112940-112940, Article 112940

2022

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Artificial Inclusion Bodies for Clinical Development

Advanced science, 2020-02, Vol.7 (3), p.1902420-n/a

2020

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Editorial: High added-value nanoparticles: Rethinking and recycling cell protein waste

Frontiers in bioengineering and biotechnology, 2022-09, Vol.10, p.1018014-1018014

2022

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Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4+ colorectal cancer models

Nanomedicine, 2016-10, Vol.12 (7), p.1987-1996

2016

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Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials

Pharmaceutics, 2022-01, Vol.14 (1), p.192

2022

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The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles

Pharmaceutics, 2022-11, Vol.14 (12), p.2644

2022

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T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo

Pharmaceutics, 2023-02, Vol.15 (3), p.727

2023

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Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors

Acta pharmaceutica Sinica. B, 2022-05, Vol.12 (5), p.2578-2591

2022

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Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids

Advanced science, 2024-06, Vol.11 (21), p.e2309427-n/a

2024

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The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies

Pharmaceutics, 2022-03, Vol.14 (3), p.602

2022

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Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Pharmaceutics, 2020-10, Vol.12 (11), p.1004

2020

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Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs

Scientific reports, 2016-10, Vol.6 (1), p.35765, Article 35765

2016

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Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4

Pharmaceutics, 2021-11, Vol.13 (11), p.1922

2021

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Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4+ Cancers

Cancers, 2021-06, Vol.13 (12), p.2929

2021

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Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation

Pharmaceutics, 2023-11, Vol.15 (11), p.2632

2023

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BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS

A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models

CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma

Selective depletion of metastatic stem cells as therapy for human colorectal cancer

GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases

Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials

Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models

Ion-dependent slow protein release from in vivo disintegrating micro-granules

A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice

Artificial Inclusion Bodies for Clinical Development

Editorial: High added-value nanoparticles: Rethinking and recycling cell protein waste

Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4+ colorectal cancer models

Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials

The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles

T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo

Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors

Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids

The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs

Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4

Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4+ Cancers

Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation

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