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SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer's Disease

International journal of molecular sciences, 2021-03, Vol.22 (7), p.3365

2021

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Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus

Neurobiology of disease, 2010-01, Vol.37 (1), p.67-76

2010

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Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

Journal of medicinal chemistry, 2011-12, Vol.54 (24), p.8251-8270

2011

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Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking

The Journal of cell biology, 2020-10, Vol.219 (10)

2020

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Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension

Biochemical pharmacology, 2019-06, Vol.164, p.115-128

2019

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Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases

Frontiers in neuroscience, 2016-11, Vol.10, p.541-541

2016

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The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease

Journal of psychiatry & neuroscience, 2017-01, Vol.42 (1), p.59-69

2017

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Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro

Current Alzheimer research, 2013-10, Vol.10 (8), p.797-808

2013

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Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia

Current pharmaceutical design, 2014-01, Vol.20 (2), p.161-171

2014

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Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors

Journal of Neural Transmission, 2013-06, Vol.120 (6), p.893-902

2013

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VAP-1/SSAO Plasma Activity and Brain Expression in Human Hemorrhagic Stroke

Cerebrovascular diseases (Basel, Switzerland), 2012-01, Vol.33 (1), p.55-63

2012

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Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain

Glia, 2008-01, Vol.56 (2), p.190-199

2008

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SSAO/VAP‐1 protein expression during mouse embryonic development

Developmental dynamics, 2008-09, Vol.237 (9), p.2585-2593

2008

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Semicarbazide-sensitive amine oxidase substrates stimulate glucose transport and inhibit lipolysis in human adipocytes

The Journal of pharmacology and experimental therapeutics, 2001-05, Vol.297 (2), p.563

2001

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Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

Progress in neurobiology, 2017-04, Vol.151, p.4-34

2017

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Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation

European journal of medicinal chemistry, 2016-10, Vol.121, p.864-879

2016

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Molecular Determinants of MAO Selectivity in a Series of Indolylmethylamine Derivatives: Biological Activities, 3D-QSAR/CoMFA Analysis, and Computational Simulation of Ligand Recognition

Journal of medicinal chemistry, 2000-05, Vol.43 (9), p.1684-1691

2000

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PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress

FEBS letters, 2002-07, Vol.523 (1), p.90-94

2002

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Role of Semicarbazide-sensitive Amine Oxidase on Glucose Transport and GLUT4 Recruitment to the Cell Surface in Adipose Cells

The Journal of biological chemistry, 1998-04, Vol.273 (14), p.8025-8032

1998

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Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

European journal of medicinal chemistry, 2014-03, Vol.75, p.82-95

2014

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Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

Frontiers in neuroscience, 2016-05, Vol.10, p.205-205

2016

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Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

European journal of medicinal chemistry, 2014-06, Vol.80, p.543-561

2014

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Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase

The journal of histochemistry and cytochemistry, 2001-02, Vol.49 (2), p.209-217

2001

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Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease

Biochimica et biophysica acta, 2014-06, Vol.1844 (6), p.1104-1110

2014

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Involvement of SSAO/VAP-1 in Oxygen-Glucose Deprivation-Mediated Damage Using the Endothelial hSSAO/VAP-1-Expressing Cells as an Experimental Model of Cerebral Ischemia

Cerebrovascular diseases (Basel, Switzerland), 2014-01, Vol.37 (3), p.171-180

2014

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SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer's Disease

Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking

Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension

Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro

Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia

Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors

VAP-1/SSAO Plasma Activity and Brain Expression in Human Hemorrhagic Stroke

Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain

SSAO/VAP‐1 protein expression during mouse embryonic development

Semicarbazide-sensitive amine oxidase substrates stimulate glucose transport and inhibit lipolysis in human adipocytes

Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation

Molecular Determinants of MAO Selectivity in a Series of Indolylmethylamine Derivatives: Biological Activities, 3D-QSAR/CoMFA Analysis, and Computational Simulation of Ligand Recognition

PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress

Role of Semicarbazide-sensitive Amine Oxidase on Glucose Transport and GLUT4 Recruitment to the Cell Surface in Adipose Cells

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease

Involvement of SSAO/VAP-1 in Oxygen-Glucose Deprivation-Mediated Damage Using the Endothelial hSSAO/VAP-1-Expressing Cells as an Experimental Model of Cerebral Ischemia

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