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Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review

European journal of pharmaceutical sciences, 2020-04, Vol.147, p.105280, Article 105280

2020

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Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models

Clinical pharmacokinetics, 2016-06, Vol.55 (6), p.673-696

2016

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Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions

Biopharmaceutics & drug disposition, 2017-04, Vol.38 (3), p.209-230

2017

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Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Drug metabolism and disposition, 2007-08, Vol.35 (8), p.1333-1340

2007

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Impact of In Vitro Passive Permeability in a P-gp-transfected LLC-PK1 Model on the Prediction of the Rat and Human Unbound Brain-to-Plasma Concentration Ratio

Pharmaceutical research, 2020-09, Vol.37 (9), p.175-175, Article 175

2020

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A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age‐dependent differences in absorption

Clinical and translational science, 2022-10, Vol.15 (10), p.2392-2402

2022

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Paracellular Porosity and Pore Size of the Human Intestinal Epithelium in Tissue and Cell Culture Models

Journal of pharmaceutical sciences, 2010-04, Vol.99 (4), p.2166-2175

2010

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Application of Azamulin to Determine the Contribution of CYP3A4/5 to Drug Metabolic Clearance Using Human Hepatocytes

Drug metabolism and disposition, 2020-09, Vol.48 (9), p.778-787

2020

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Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination

The AAPS journal, 2016-05, Vol.18 (3), p.589-604

2016

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Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells

European journal of pharmaceutical sciences, 2006-07, Vol.28 (4), p.291-299

2006

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Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered medicines

Advanced drug delivery reviews, 2022-02, Vol.181, p.114084-114084, Article 114084

2022

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pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: Implications for drug-drug interactions

Pharmaceutical research, 2003-08, Vol.20 (8), p.1141-1148

2003

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The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux

European journal of pharmaceutical sciences, 2006-09, Vol.29 (1), p.70-81

2006

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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

European journal of pharmaceutical sciences, 2008-12, Vol.35 (5), p.383-396

2008

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Comprehensive study on regional human intestinal permeability and prediction of fraction absorbed of drugs using the Ussing chamber technique

European journal of pharmaceutical sciences, 2013-01, Vol.48 (1-2), p.166-180

2013

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Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro

Drug metabolism and disposition, 2008-03, Vol.36 (3), p.604-613

2008

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Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations

Drug metabolism and disposition, 2006-11, Vol.34 (11), p.1893-1902

2006

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Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics

Drug metabolism and disposition, 2021-12, Vol.49 (12), p.1038-1046

2021

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Characterization of fluids from the stomach and proximal jejunum in men and women

Pharmaceutical research, 1997-04, Vol.14 (4), p.497-502

1997

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Correlation of Drug Absorption with Molecular Surface Properties

Journal of pharmaceutical sciences, 1996-01, Vol.85 (1), p.32-39

1996

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In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug interactions

Drug metabolism and disposition, 2009-06, Vol.37 (6), p.1286-1294

2009

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Impact of extracellular protein binding on passive and active drug transport across caco-2 cells

Pharmaceutical research, 2006-02, Vol.23 (2), p.350-359

2006

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(-)- N -3-Benzylphenobarbital Is Superior to Omeprazole and (+)- N -3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes

Drug metabolism and disposition, 2020-11, Vol.48 (11), p.1121-1128

2020

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Lysosomal trapping of amodiaquine: impact on transport across intestinal epithelia models

Biopharmaceutics & drug disposition, 2008-09, Vol.29 (6), p.324-334

2008

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Impact of input parameters on the prediction of hepatic plasma clearance using the well-stirred model

Current drug metabolism, 2010-09, Vol.11 (7), p.583-594

2010

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Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review

Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models

Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Impact of In Vitro Passive Permeability in a P-gp-transfected LLC-PK1 Model on the Prediction of the Rat and Human Unbound Brain-to-Plasma Concentration Ratio

A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age‐dependent differences in absorption

Paracellular Porosity and Pore Size of the Human Intestinal Epithelium in Tissue and Cell Culture Models

Application of Azamulin to Determine the Contribution of CYP3A4/5 to Drug Metabolic Clearance Using Human Hepatocytes

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells

Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered medicines

pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: Implications for drug-drug interactions

The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Comprehensive study on regional human intestinal permeability and prediction of fraction absorbed of drugs using the Ussing chamber technique

Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro

Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations

Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics

Characterization of fluids from the stomach and proximal jejunum in men and women

Correlation of Drug Absorption with Molecular Surface Properties

In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug interactions

Impact of extracellular protein binding on passive and active drug transport across caco-2 cells

(-)- N -3-Benzylphenobarbital Is Superior to Omeprazole and (+)- N -3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes

Lysosomal trapping of amodiaquine: impact on transport across intestinal epithelia models

Impact of input parameters on the prediction of hepatic plasma clearance using the well-stirred model

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