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Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

Journal of medicinal chemistry, 2008-09, Vol.51 (17), p.5172-5175

2008

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Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1309-1313

2017

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Angiotensin (1–7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor

Cellular signalling, 2018-10, Vol.50, p.9-24

2018

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Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor

Pharmacological research, 2018-05, Vol.131, p.185-198

2018

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Differential tissue and ligand-dependent signaling of GPR109A receptor: Implications for anti-atherosclerotic therapeutic potential

Cellular signalling, 2013-10, Vol.25 (10), p.2003-2016

2013

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Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.645

2013

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Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

Bioorganic & medicinal chemistry letters, 2020-03, Vol.30 (5), p.126929, Article 126929

2020

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Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor

ACS medicinal chemistry letters, 2014-12, Vol.5 (12), p.1313-1317

2014

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Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (15), p.3034-3038

2015

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Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat

Bioorganic & medicinal chemistry letters, 2015-03, Vol.25 (5), p.1030-1035

2015

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Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4332-4335

2014

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Design of a new series of potent and selective beta-3 adrenergic receptor (β3-AdrR) antagonists for the treatment of acute decompensated heart failure

Results in Chemistry, 2022-01, Vol.4, p.100518, Article 100518

2022

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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.322-326

2015

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Discovery of APD371: Identification of a Highly Potent and Selective CB 2 Agonist for the Treatment of Chronic Pain

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1309-1313

2017

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(7‑Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2‑a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists

ACS medicinal chemistry letters, 2014-12, Vol.5 (12), p.1334-1339

2014

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Singlet State Cis,Trans Photoisomerization and Intersystem Crossing of 1-Arylpropenes

Journal of the American Chemical Society, 1994-11, Vol.116 (23), p.10477-10485

1994

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Functional Activity of Etrasimod and a Diverse Panel of Sphingosine‐1‐Phosphate Receptor (S1PR1) Modulators at S1P4 Receptors

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Etrasimod, a Novel Sphingosine‐1‐Phosphate Receptor (S1PR1) Modulator, Lacks Functional Activity at S1P2 Receptors

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Photocycloaddition of 4,4-Dimethylcyclohexenone to 1,1-Diphenylethylene. Evidence for a Triplet Exciplex Intermediate

Journal of the American Chemical Society, 1996-09, Vol.118 (36), p.8741-8742

1996

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Discovery of a lead series of potent benzodiazepine 5-HT 2C receptor agonists with high selectivity in functional and binding assays

Bioorganic & medicinal chemistry letters, 2020-03, Vol.30 (5), p.126929

2020

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Kinetics of 5-HT 2B Receptor Signaling: Profound Agonist-Dependent Effects on Signaling Onset and Duration

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.645-659

2013

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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxam i des as potent and selective CB sub(2) receptor agonists

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.322-326

2015

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Alkene Triplets as 1,2-Biradicals: The Photoaddition of p-Acetylstyrene to Styrene

Journal of the American Chemical Society, 1994-09, Vol.116 (18), p.8138-8145

1994

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Photodimerization of 1-Phenylcyclohexene. A Novel Transient−Transient Component

Journal of the American Chemical Society, 1996-02, Vol.118 (7), p.1682-1689

1996

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Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain

Angiotensin (1–7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor

Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor

Differential tissue and ligand-dependent signaling of GPR109A receptor: Implications for anti-atherosclerotic therapeutic potential

Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration

Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

Discovery of 2‑(((1r,4r)‑4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor

Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists

Design of a new series of potent and selective beta-3 adrenergic receptor (β3-AdrR) antagonists for the treatment of acute decompensated heart failure

Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists

Discovery of APD371: Identification of a Highly Potent and Selective CB 2 Agonist for the Treatment of Chronic Pain

(7‑Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2‑a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists

Singlet State Cis,Trans Photoisomerization and Intersystem Crossing of 1-Arylpropenes

Functional Activity of Etrasimod and a Diverse Panel of Sphingosine‐1‐Phosphate Receptor (S1PR1) Modulators at S1P4 Receptors

Etrasimod, a Novel Sphingosine‐1‐Phosphate Receptor (S1PR1) Modulator, Lacks Functional Activity at S1P2 Receptors

Photocycloaddition of 4,4-Dimethylcyclohexenone to 1,1-Diphenylethylene. Evidence for a Triplet Exciplex Intermediate

Discovery of a lead series of potent benzodiazepine 5-HT 2C receptor agonists with high selectivity in functional and binding assays

Kinetics of 5-HT 2B Receptor Signaling: Profound Agonist-Dependent Effects on Signaling Onset and Duration

Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxam i des as potent and selective CB sub(2) receptor agonists

Alkene Triplets as 1,2-Biradicals: The Photoaddition of p-Acetylstyrene to Styrene

Photodimerization of 1-Phenylcyclohexene. A Novel Transient−Transient Component

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