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Serelaxin in clinical development: past, present and future

British journal of pharmacology, 2017-05, Vol.174 (10), p.921-932

Unemori, Elaine

2017

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Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study

The Lancet (British edition), 2009-04, Vol.373 (9673), p.1429-1439

2009

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Intravenous Recombinant Human Relaxin in Compensated Heart Failure: A Safety, Tolerability, and Pharmacodynamic Trial

Journal of cardiac failure, 2009-04, Vol.15 (3), p.182-190

2009

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Relaxin Modulates Cardiac Fibroblast Proliferation, Differentiation, and Collagen Production and Reverses Cardiac Fibrosis in Vivo

Endocrinology (Philadelphia), 2004-09, Vol.145 (9), p.4125-4133

2004

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Early drop in systolic blood pressure and worsening renal function in acute heart failure: renal results of Pre-RELAX-AHF

European journal of heart failure, 2011-09, Vol.13 (9), p.961-967

2011

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Relaxin: Review of Biology and Potential Role in Treating Heart Failure

Current heart failure reports, 2010-06, Vol.7 (2), p.75-82

2010

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Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation

Reproductive biology and endocrinology, 2016-03, Vol.14 (1), p.11-11, Article 11

2016

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Design of the RELAXin in Acute Heart Failure Study

The American heart journal, 2012-02, Vol.163 (2), p.149-155.e1

2012

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Relaxin, a pleiotropic vasodilator for the treatment of heart failure

Heart failure reviews, 2009-12, Vol.14 (4), p.321-329

2009

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Liver Function, In-Hospital, and Post-Discharge Clinical Outcome in Patients With Acute Heart Failure—Results From the Relaxin for the Treatment of Patients With Acute Heart Failure Study

Journal of cardiac failure, 2014-06, Vol.20 (6), p.407-413

2014

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Relaxin family peptide receptors – from orphans to therapeutic targets

Drug discovery today, 2008-08, Vol.13 (15), p.640-651

2008

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Effect of Serelaxin on Mode of Death in Acute Heart Failure

Journal of the American College of Cardiology, 2014-10, Vol.64 (15), p.1591-1598

2014

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A Randomized, Double-Blind, Placebo-Controlled Trial of Relaxin for Cervical Ripening in Post-Delivery Date Pregnancies

Annals of the New York Academy of Sciences, 2009-04, Vol.1160 (1), p.385-386

2009

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Cytokine-Stimulated Human Vascular Smooth Muscle Cells Synthesize a Complement of Enzymes Required for Extracellular Matrix Digestion

Circulation research, 1994-07, Vol.75 (1), p.181-189

1994

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Relaxin Modulates Fibroblast Function, Collagen Production, and Matrix Metalloproteinase-2 Expression by Cardiac Fibroblasts

Annals of the New York Academy of Sciences, 2005-05, Vol.1041 (1), p.190-193

2005

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Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites

Wound repair and regeneration, 2000-09, Vol.8 (5), p.361-370

2000

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Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women

Human reproduction (Oxford), 1999-03, Vol.14 (3), p.800-806

1999

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Effect of Serelaxin on Cardiac, Renal, and Hepatic Biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) Development Program: Correlation With Outcomes

Journal of the American College of Cardiology, 2013-01, Vol.61 (2), p.196-206

2013

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Serelaxin in acute heart failure patients with preserved left ventricular ejection fraction: results from the RELAX-AHF trial

European heart journal, 2014-04, Vol.35 (16), p.1041-1050

2014

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Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

Journal of cellular physiology, 1992-12, Vol.153 (3), p.557-562

1992

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Relaxin activates the MAP kinase pathway in human endometrial stromal cells

Journal of cellular biochemistry, 2002, Vol.85 (3), p.536-544

2002

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Peptide hormone relaxin: from bench to bedside

American journal of physiology. Regulatory, integrative and comparative physiology, 2018-06, Vol.314 (6), p.R753-R760

2018

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Recombinant human relaxin reduces hypoxic pulmonary hypertension in the rat

Pulmonary pharmacology & therapeutics, 2005-01, Vol.18 (5), p.346-353

2005

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Effects of serelaxin in subgroups of patients with acute heart failure: results from RELAX-AHF

European heart journal, 2013-10, Vol.34 (40), p.3128-3136

2013

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Effect of serelaxin on mode of death in acute heart failure: results from the RELAX-AHF study

Journal of the American College of Cardiology, 2014-10, Vol.64 (15), p.1591-1598

2014

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Serelaxin in clinical development: past, present and future

Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study

Intravenous Recombinant Human Relaxin in Compensated Heart Failure: A Safety, Tolerability, and Pharmacodynamic Trial

Relaxin Modulates Cardiac Fibroblast Proliferation, Differentiation, and Collagen Production and Reverses Cardiac Fibrosis in Vivo

Early drop in systolic blood pressure and worsening renal function in acute heart failure: renal results of Pre-RELAX-AHF

Relaxin: Review of Biology and Potential Role in Treating Heart Failure

Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation

Design of the RELAXin in Acute Heart Failure Study

Relaxin, a pleiotropic vasodilator for the treatment of heart failure

Liver Function, In-Hospital, and Post-Discharge Clinical Outcome in Patients With Acute Heart Failure—Results From the Relaxin for the Treatment of Patients With Acute Heart Failure Study

Relaxin family peptide receptors – from orphans to therapeutic targets

Effect of Serelaxin on Mode of Death in Acute Heart Failure

A Randomized, Double-Blind, Placebo-Controlled Trial of Relaxin for Cervical Ripening in Post-Delivery Date Pregnancies

Cytokine-Stimulated Human Vascular Smooth Muscle Cells Synthesize a Complement of Enzymes Required for Extracellular Matrix Digestion

Relaxin Modulates Fibroblast Function, Collagen Production, and Matrix Metalloproteinase-2 Expression by Cardiac Fibroblasts

Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites

Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women

Effect of Serelaxin on Cardiac, Renal, and Hepatic Biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) Development Program: Correlation With Outcomes

Serelaxin in acute heart failure patients with preserved left ventricular ejection fraction: results from the RELAX-AHF trial

Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

Relaxin activates the MAP kinase pathway in human endometrial stromal cells

Peptide hormone relaxin: from bench to bedside

Recombinant human relaxin reduces hypoxic pulmonary hypertension in the rat

Effects of serelaxin in subgroups of patients with acute heart failure: results from RELAX-AHF

Effect of serelaxin on mode of death in acute heart failure: results from the RELAX-AHF study

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