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Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells

Blood, 2006-02, Vol.107 (4), p.1617-1623

2006

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Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates

Anti-cancer agents in medicinal chemistry, 2010-01, Vol.10 (1), p.7-27

2010

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Synthesis and structure–activity relationships of 1,2,3,4-tetrahydropyrido[2,3- b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase

Bioorganic & medicinal chemistry, 2010-06, Vol.18 (12), p.4351-4362

2010

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Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.164-167

2011

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Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3877-3880

2011

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2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7325-7330

2011

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Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group

Bioorganic & medicinal chemistry, 2011-11, Vol.19 (21), p.6274-6284

2011

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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.133-137

2012

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Discovery of a Potent Inhibitor of Anaplastic Lymphoma Kinase with in Vivo Antitumor Activity

ACS medicinal chemistry letters, 2010-12, Vol.1 (9), p.493-498

2010

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2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (2), p.660-663

2011

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8-THP-DHI analogs as potent Type I dual TIE-2/VEGF-R2 receptor tyrosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3356-3360

2010

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First Synthesis of Cytotoxic 8,9-Secokaurene Diterpenoids. An Enantioselective Route to (−)-O-Methylshikoccin and (+)-O-Methylepoxyshikoccin

Journal of the American Chemical Society, 1997-10, Vol.119 (41), p.9662-9671

1997

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TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4- a]pyrrolo[3,4- c]carbazole analogs

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (7), p.2368-2372

2008

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CT2108A and B: New Fatty Acid Synthase Inhibitors as Antifungal Agents

Journal of natural products (Washington, D.C.), 2003-08, Vol.66 (8), p.1041-1046

2003

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Syntheses of C12,N13 Heterocyclic Bridged Fused Indenopyrrolocarbazoles

Journal of organic chemistry, 2002-05, Vol.67 (10), p.3235-3241

2002

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Stabilization demands of diethyl phosphonate substituted carbocations as revealed by substituent effects

Journal of organic chemistry, 1985-06, Vol.50 (12), p.2165-2170

1985

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Diels-Alder approach to bicyclic .alpha.-hydroxy ketones. Facile ketol rearrangements of strained .alpha.-hydroxy ketones

Journal of organic chemistry, 1985-05, Vol.50 (11), p.1932-1938

1985

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Designing Chemical Libraries for Lead Discovery

SLAS discovery, 1996-03, Vol.1 (2), p.65-73

1996

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Alkylation of allylic derivatives. 17. Cross-coupling reactions of diallylic pivalates with butyl- and phenylcopper reagents

Journal of organic chemistry, 1991-03, Vol.56 (7), p.2563-2572

1991

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Structural analysis of cis-[n.3.1]bicyclic ketones by x-ray crystallography. Impact of the observed conformational crossover by .pi.-facially diastereoselective nucleophilic additions to this class of ketones and on the stereochemical course of electrophilic reactions involving their methylene analogs

Journal of organic chemistry, 1992-01, Vol.57 (1), p.86-96

1992

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Cross coupling of allylic derivatives. 16. Regiochemistry of cross coupling of the isomeric (E,E)-3,5-heptadien-2-yl and (E,E)-2,5-heptadien-4-yl pivalates with organocopper and Grignard reagents

Journal of organic chemistry, 1990-04, Vol.55 (9), p.2757-2761

1990

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Alkylation of allylic derivatives. 14. Relationship of double-bond configuration between reactant and product for cross-coupling reactions of Z-allylic carboxylates with organocopper reagents

Journal of organic chemistry, 1989-05, Vol.54 (10), p.2369-2374

1989

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Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells

Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates

Synthesis and structure–activity relationships of 1,2,3,4-tetrahydropyrido[2,3- b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase

Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors

Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors

2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation

Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

Discovery of a Potent Inhibitor of Anaplastic Lymphoma Kinase with in Vivo Antitumor Activity

2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines

8-THP-DHI analogs as potent Type I dual TIE-2/VEGF-R2 receptor tyrosine kinase inhibitors

First Synthesis of Cytotoxic 8,9-Secokaurene Diterpenoids. An Enantioselective Route to (−)-O-Methylshikoccin and (+)-O-Methylepoxyshikoccin

TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4- a]pyrrolo[3,4- c]carbazole analogs

CT2108A and B: New Fatty Acid Synthase Inhibitors as Antifungal Agents

Syntheses of C12,N13 Heterocyclic Bridged Fused Indenopyrrolocarbazoles

Stabilization demands of diethyl phosphonate substituted carbocations as revealed by substituent effects

Diels-Alder approach to bicyclic .alpha.-hydroxy ketones. Facile ketol rearrangements of strained .alpha.-hydroxy ketones

Designing Chemical Libraries for Lead Discovery

Alkylation of allylic derivatives. 17. Cross-coupling reactions of diallylic pivalates with butyl- and phenylcopper reagents

Cross coupling of allylic derivatives. 16. Regiochemistry of cross coupling of the isomeric (E,E)-3,5-heptadien-2-yl and (E,E)-2,5-heptadien-4-yl pivalates with organocopper and Grignard reagents

Alkylation of allylic derivatives. 14. Relationship of double-bond configuration between reactant and product for cross-coupling reactions of Z-allylic carboxylates with organocopper reagents

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