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Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031

Scientific reports, 2019-05, Vol.9 (1), p.7643, Article 7643

2019

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Systems Biology Reveals New Strategies for Personalizing Cancer Medicine and Confirms the Role of PTEN in Resistance to Trastuzumab

Cancer research (Chicago, Ill.), 2009-08, Vol.69 (16), p.6713-6720

2009

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Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system

Scientific reports, 2015-06, Vol.5 (1), p.10775-10775, Article 10775

2015

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OP2 Knock-out of MG23 cardioprotects against pressure-overload induced cardiac hypertrophy and cardiac dysfunction

Heart (British Cardiac Society), 2024-04, Vol.110 (Suppl 2), p.A3-A3

2024

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NUC-7738 regulates β-catenin signalling resulting in reduced proliferation and self-renewal of AML cells

PloS one, 2022-12, Vol.17 (12), p.e0278209-e0278209

2022

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HoechstGAN: Virtual Lymphocyte Staining Using Generative Adversarial Networks

2023 IEEE/CVF Winter Conference on Applications of Computer Vision (WACV), 2023, p.4986-4996

2023

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Evaluation of the dual mTOR/PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models

Scientific reports, 2019-12, Vol.9 (1), p.18742-9, Article 18742

2019

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Lymphocyte Classification from Hoechst Stained Slides with Deep Learning

Cancers, 2022-12, Vol.14 (23), p.5957

2022

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Defining the mode of action of cisplatin combined with NUC-1031, a phosphoramidate modification of gemcitabine

Translational oncology, 2024-12, Vol.50, p.102114, Article 102114

2024

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Spatial Analysis of NQO1 in Non-Small Cell Lung Cancer Shows Its Expression Is Independent of NRF1 and NRF2 in the Tumor Microenvironment

Biomolecules (Basel, Switzerland), 2022-11, Vol.12 (11), p.1652

2022

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Use of High-Plex Data Reveals Novel Insights into the Tumour Microenvironment of Clear Cell Renal Cell Carcinoma

Cancers, 2022-11, Vol.14 (21), p.5387

2022

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Whole-Slide Images and Patches of Clear Cell Renal Cell Carcinoma Tissue Sections Counterstained with Hoechst 33342, CD3, and CD8 Using Multiple Immunofluorescence

Data (Basel), 2023-02, Vol.8 (2), p.40

2023

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Transcription Factor NFE2L1 Decreases in Glomerulonephropathies after Podocyte Damage

Cells (Basel, Switzerland), 2023-08, Vol.12 (17), p.2165

2023

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YAP Translocation Precedes Cytoskeletal Rearrangement in Podocyte Stress Response: A Podometric Investigation of Diabetic Nephropathy

Frontiers in physiology, 2021-07, Vol.12, p.625762-625762

2021

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NUC-7738 regulates [beta]-catenin signalling resulting in reduced proliferation and self-renewal of AML cells

PloS one, 2022-12, Vol.17 (12), p.e0278209

2022

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Tissue-Specific Immunopathology in Fatal COVID-19

American journal of respiratory and critical care medicine, 2021-01, Vol.203 (2), p.192-201

2021

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Defining corticosteroid-regulated sodium transport within the distal nephron

Physiology (Bethesda, Md.), 2023-05, Vol.38 (S1)

2023

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Abstract P026: NUC-7738 alters oxidative phosphorylation and causes terminal differentiation in acute myeloid leukemia cells

Molecular cancer therapeutics, 2021-12, Vol.20 (12_Supplement), p.P026-P026

2021

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DESI-MSI-guided exploration of metabolic-phenotypic relationships reveals a correlation between PI 38:3 and proliferating cells in clear cell renal cell carcinoma via single-section co-registration of multimodal imaging

Analytical and bioanalytical chemistry, 2024-07, Vol.416 (18), p.4015-4028

2024

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Abstract 2082: NUC 3373 induces a cytoplasmic translocation of thymidylate synthase in colorectal carcinoma cell lines

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2082-2082

2019

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The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance Mechanisms In Vitro and in a First-In-Human Phase I Clinical Trial

Clinical cancer research, 2021-12, Vol.27 (23), p.6500-6513

2021

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Abstract 1855: NUC-1031 overcomes resistance associated with gemcitabine in cancer patients

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1855-1855

2018

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Abstract 572: Genome-scale CRISPR/Cas9 screen identifies factors required for sensitivity to pyrimidine nucleoside analogs

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.572-572

2018

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Abstract C122: NUC-7738, a novel ProTide modification of 3’-deoxyadenosine, activates AMPK and kills renal cancer cells in vitro

Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.C122-C122

2019

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Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models

Oncotarget, 2015-09, Vol.6 (28), p.24856-24870

2015

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Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031

Systems Biology Reveals New Strategies for Personalizing Cancer Medicine and Confirms the Role of PTEN in Resistance to Trastuzumab

Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system

OP2 Knock-out of MG23 cardioprotects against pressure-overload induced cardiac hypertrophy and cardiac dysfunction

NUC-7738 regulates β-catenin signalling resulting in reduced proliferation and self-renewal of AML cells

HoechstGAN: Virtual Lymphocyte Staining Using Generative Adversarial Networks

Evaluation of the dual mTOR/PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models

Lymphocyte Classification from Hoechst Stained Slides with Deep Learning

Defining the mode of action of cisplatin combined with NUC-1031, a phosphoramidate modification of gemcitabine

Spatial Analysis of NQO1 in Non-Small Cell Lung Cancer Shows Its Expression Is Independent of NRF1 and NRF2 in the Tumor Microenvironment

Use of High-Plex Data Reveals Novel Insights into the Tumour Microenvironment of Clear Cell Renal Cell Carcinoma

Whole-Slide Images and Patches of Clear Cell Renal Cell Carcinoma Tissue Sections Counterstained with Hoechst 33342, CD3, and CD8 Using Multiple Immunofluorescence

Transcription Factor NFE2L1 Decreases in Glomerulonephropathies after Podocyte Damage

YAP Translocation Precedes Cytoskeletal Rearrangement in Podocyte Stress Response: A Podometric Investigation of Diabetic Nephropathy

NUC-7738 regulates [beta]-catenin signalling resulting in reduced proliferation and self-renewal of AML cells

Tissue-Specific Immunopathology in Fatal COVID-19

Defining corticosteroid-regulated sodium transport within the distal nephron

Abstract P026: NUC-7738 alters oxidative phosphorylation and causes terminal differentiation in acute myeloid leukemia cells

DESI-MSI-guided exploration of metabolic-phenotypic relationships reveals a correlation between PI 38:3 and proliferating cells in clear cell renal cell carcinoma via single-section co-registration of multimodal imaging

Abstract 2082: NUC 3373 induces a cytoplasmic translocation of thymidylate synthase in colorectal carcinoma cell lines

The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance Mechanisms In Vitro and in a First-In-Human Phase I Clinical Trial

Abstract 1855: NUC-1031 overcomes resistance associated with gemcitabine in cancer patients

Abstract 572: Genome-scale CRISPR/Cas9 screen identifies factors required for sensitivity to pyrimidine nucleoside analogs

Abstract C122: NUC-7738, a novel ProTide modification of 3’-deoxyadenosine, activates AMPK and kills renal cancer cells in vitro

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models

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