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Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells

PloS one, 2015-02, Vol.10 (2), p.e0116703-e0116703

2015

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Uptake, Efficacy, and Systemic Distribution of Naked, Inhaled Short Interfering RNA (siRNA) and Locked Nucleic Acid (LNA) Antisense

Molecular therapy, 2011-12, Vol.19 (12), p.2163-2168

2011

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Identification and quantification of GC-rich oligodeoxynucleotides in tissue extracts by capillary gel electrophoresis

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-03, Vol.847 (2), p.153-161

2007

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Structure-Activity Relationship Studies on the Immune Stimulatory Effects of Base-Modified CpG Toll-Like Receptor 9 Agonists

ChemMedChem, 2006-09, Vol.1 (9), p.1007-1014

2006

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Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells

Molecular therapy. Nucleic acids, 2012, Vol.1 (4), p.e16-e16, Article e16

2012

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The synthesis of polyamide nucleic acids using a novel monomethoxytrityl protecting-group strategy

Tetrahedron, 1995-10, Vol.51 (44), p.12069-12082

1995

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Therapeutic oligonucleotides

Kurreck, Jens

1, 2008

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PNA: Synthetic Polyamide Nucleic Acids with Unusual Binding Properties

Angewandte Chemie (International ed.), 1998-11, Vol.37 (20), p.2796-2823

1998

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Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers

Nucleic acids research, 2015-10, Vol.43 (19), p.9123-9132

2015

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Peptide nucleic acids (PNA) and PNA-DNA chimeras: from high binding affinity towards biological function

Biological chemistry, 1998-08, Vol.379 (8-9), p.1045-1052

Uhlmann, E

1998

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Guanine modification of inhibitory oligonucleotides potentiates their suppressive function

The Journal of immunology (1950), 2013-09, Vol.191 (6), p.3240-3253

2013

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Antisense oligonucleotides: a new therapeutic principle

Chemical reviews, 1990-06, Vol.90 (4), p.543-584

1990

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Antisense-Oligonucleotide - ein universelles Therapieprinzip

Chemie in unserer Zeit, 1998-06, Vol.32 (3), p.150-160

Uhlmann, Eugen

1998

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Synthesis and Properties of PNA/DNA Chimeras

Angewandte Chemie (International ed.), 1996-12, Vol.35 (22), p.2632-2635

1996

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c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption

Nature (London), 1996-10, Vol.383 (6600), p.528-531

1996

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Dual or triple activation of TLR7, TLR8, and/or TLR9 by single-stranded oligoribonucleotides

Nucleic acid therapeutics, 2011-12, Vol.21 (6), p.423-436

2011

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Expression of Met-(−1) angiogenin in Escherichia coli: Conversion to the authentic <Glu-1 protein

Analytical biochemistry, 1988, Vol.175 (2), p.450-461

1988

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Synthesis and duplex stability of oligodeoxynucleotides containing stereoregular or stereorandom octylphosphonate linkages

Tetrahedron, 1996-07, Vol.52 (30), p.10011-10024

1996

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Guanine-Modified Inhibitory Oligonucleotides Efficiently Impair TLR7- and TLR9-Mediated Immune Responses of Human Immune Cells: e0116703

PloS one, 2015-02, Vol.10 (2)

2015

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C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level

Immunobiology (1979), 2004-01, Vol.209 (1), p.141-154

2004

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Biodistribution and metabolism of immunostimulatory oligodeoxynucleotide CPG 7909 in mouse and rat tissues following subcutaneous administration

Biochemical pharmacology, 2005-03, Vol.69 (6), p.981-991

2005

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Oligonucleotide technologies: synthesis, production, regulations and applications

Expert opinion on biological therapy, 2001-03, Vol.1 (2), p.319-328

Uhlmann, Eugen

2001

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Use of minimally modified antisense oligonucleotides for specific inhibition of gene expression

Methods in Enzymology, 2000, Vol.313, p.268-284

2000

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Novel synthetic routes to PNA monomers and PNA-DNA linker molecules

Tetrahedron, 1997-10, Vol.53 (43), p.14671-14686

1997

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Antisense‐Oligonucleotide – ein universelles Therapieprinzip

Chemie in unserer Zeit, 1998-06, Vol.32 (3), p.150-160

Uhlmann, Eugen

1998

Volltextzugriff (PDF)

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Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells

Uptake, Efficacy, and Systemic Distribution of Naked, Inhaled Short Interfering RNA (siRNA) and Locked Nucleic Acid (LNA) Antisense

Identification and quantification of GC-rich oligodeoxynucleotides in tissue extracts by capillary gel electrophoresis

Structure-Activity Relationship Studies on the Immune Stimulatory Effects of Base-Modified CpG Toll-Like Receptor 9 Agonists

Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells

The synthesis of polyamide nucleic acids using a novel monomethoxytrityl protecting-group strategy

Therapeutic oligonucleotides

PNA: Synthetic Polyamide Nucleic Acids with Unusual Binding Properties

Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers

Peptide nucleic acids (PNA) and PNA-DNA chimeras: from high binding affinity towards biological function

Guanine modification of inhibitory oligonucleotides potentiates their suppressive function

Antisense oligonucleotides: a new therapeutic principle

Antisense-Oligonucleotide - ein universelles Therapieprinzip

Synthesis and Properties of PNA/DNA Chimeras

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption

Dual or triple activation of TLR7, TLR8, and/or TLR9 by single-stranded oligoribonucleotides

Expression of Met-(−1) angiogenin in Escherichia coli: Conversion to the authentic <Glu-1 protein

Synthesis and duplex stability of oligodeoxynucleotides containing stereoregular or stereorandom octylphosphonate linkages

Guanine-Modified Inhibitory Oligonucleotides Efficiently Impair TLR7- and TLR9-Mediated Immune Responses of Human Immune Cells: e0116703

C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level

Biodistribution and metabolism of immunostimulatory oligodeoxynucleotide CPG 7909 in mouse and rat tissues following subcutaneous administration

Oligonucleotide technologies: synthesis, production, regulations and applications

Use of minimally modified antisense oligonucleotides for specific inhibition of gene expression

Novel synthetic routes to PNA monomers and PNA-DNA linker molecules

Antisense‐Oligonucleotide – ein universelles Therapieprinzip

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