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Pharmacological properties of ASP7657, a novel, potent, and selective prostaglandin EP4 receptor antagonist

Naunyn-Schmiedeberg's archives of pharmacology, 2018-12, Vol.391 (12), p.1319-1326

2018

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Renoprotective effects of the novel prostaglandin EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized chronic kidney disease rats

Naunyn-Schmiedeberg's archives of pharmacology, 2019-04, Vol.392 (4), p.451-459

2019

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Synthesis and Biological Evaluation of Quinuclidine Derivatives Incorporating Phenothiazine Moieties as Squalene Synthase Inhibitors

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(10), pp.1204-1209

2004

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Pharmacokinetic/pharmacodynamic modeling of roxadustat's effect on LDL cholesterol in patients in Japan with dialysis-dependent chronic kidney disease and anemia

Drug metabolism and pharmacokinetics, 2022-10, Vol.46, p.100461-100461, Article 100461

2022

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Effect of antiemetics on zolbetuximab-induced gastric injury and emesis in ferrets

Journal of pharmacological sciences, 2024-11, Vol.156 (3), p.161-170

2024

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YM‐53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species

British journal of pharmacology, 2000-09, Vol.131 (1), p.63-70

2000

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Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors

Bioorganic & medicinal chemistry, 2004-11, Vol.12 (22), p.5899-5908

2004

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Roxadustat (Evrenzo® tablet), a therapeutic drug for renal anemia: pharmacological characteristics and clinical evidence in Japan

Folia Pharmacologica Japonica, 2021, Vol.156(3), pp.187-197

2021

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Characterization of the Pharmacology of YM-198313 on Volume-Regulated Anion Channels

Biological and Pharmaceutical Bulletin, 2005, Vol.28(7), pp.1187-1191

2005

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Syntheses and biological evaluation of novel quinuclidine derivatives as squalene synthase inhibitors

Bioorganic & medicinal chemistry, 2003-05, Vol.11 (11), p.2403-2414

2003

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腎性貧血治療薬ロキサデュスタット（エベレンゾ®錠）の薬理学的特徴および国内臨床試験成績

日本薬理学雑誌, 2021, Vol.156(3), pp.187-197

2021

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Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat

The Journal of clinical investigation, 2006-02, Vol.116 (2), p.395-404

2006

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Enhancing effects of NaCl and Na phosphate on human gustatory responses to amino acids

Chemical senses, 1992-12, Vol.17 (6), p.811-815

1992

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Effect of YM‐53601, a novel squalene synthase inhibitor, on the clearance rate of plasma LDL and VLDL in hamsters

British journal of pharmacology, 2002-10, Vol.137 (4), p.561-567

2002

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YM‐53601, a novel squalene synthase inhibitor, suppresses lipogenic biosynthesis and lipid secretion in rodents

British journal of pharmacology, 2003-05, Vol.139 (1), p.140-146

2003

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Experimental model of escape phenomenon in hamsters and the effectiveness of YM‐53601 in the model

British journal of pharmacology, 2002-03, Vol.135 (6), p.1572-1578

2002

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Syntheses of 3-Ethylidenequinuclidine derivatives as squalene synthase inhibitors. Part 2: enzyme inhibition and effects on plasma lipid levels

Bioorganic & medicinal chemistry, 2003-08, Vol.11 (17), p.3735-3745

2003

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O-20137 A novel volume-regulated anion channel inhibitor, YM-255693, prevents ischemia-induced arrhythmia in rats

Journal of Pharmacological Sciences, 2004, Vol.94 (suppl.1), p.108-108

2004

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Enhancement of canine taste responses to umami substances by salts

American journal of physiology. Regulatory, integrative and comparative physiology, 1994-03, Vol.35 (3), p.R944

1994

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Large enhancement of canine taste responses to amino acids by salts

American journal of physiology. Regulatory, integrative and comparative physiology, 1993-06, Vol.33 (6), p.R1071-R1076

1993

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Cholesterol-lowering effect of YM-16638 in cynomolgus monkeys

Drug development research, 1996-06, Vol.38 (2), p.86-92

1996

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Synthesis and Biological Evaluation of Quinuclidine Derivatives Incorporating Phenothiazine Moieties as Squalene Synthase Inhibitors

ChemInform, 2005-03, Vol.36 (13), p.no-no

2005

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Endogenous dopamine release induced by repetitive transcranial magnetic stimulation over the primary motor cortex: an [11C]raclopride positron emission tomography study in anesthetized macaque monkeys

Biological psychiatry (1969), 2004-03, Vol.55 (5), p.484-489

2004

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Long-term effect of motor cortical repetitive transcranial magnetic stimulation induces

Annals of neurology, 2004-07, Vol.56 (1), p.77-85

2004

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Long-term effect of motor cortical repetitive transcranial magnetic stimulation [correction]

Annals of neurology, 2004-07, Vol.56 (1), p.77-85

2004

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Pharmacological properties of ASP7657, a novel, potent, and selective prostaglandin EP4 receptor antagonist

Renoprotective effects of the novel prostaglandin EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized chronic kidney disease rats

Synthesis and Biological Evaluation of Quinuclidine Derivatives Incorporating Phenothiazine Moieties as Squalene Synthase Inhibitors

Pharmacokinetic/pharmacodynamic modeling of roxadustat's effect on LDL cholesterol in patients in Japan with dialysis-dependent chronic kidney disease and anemia

Effect of antiemetics on zolbetuximab-induced gastric injury and emesis in ferrets

YM‐53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species

Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors

Roxadustat (Evrenzo® tablet), a therapeutic drug for renal anemia: pharmacological characteristics and clinical evidence in Japan

Characterization of the Pharmacology of YM-198313 on Volume-Regulated Anion Channels

Syntheses and biological evaluation of novel quinuclidine derivatives as squalene synthase inhibitors

腎性貧血治療薬ロキサデュスタット（エベレンゾ®錠）の薬理学的特徴および国内臨床試験成績

Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat

Enhancing effects of NaCl and Na phosphate on human gustatory responses to amino acids

Effect of YM‐53601, a novel squalene synthase inhibitor, on the clearance rate of plasma LDL and VLDL in hamsters

YM‐53601, a novel squalene synthase inhibitor, suppresses lipogenic biosynthesis and lipid secretion in rodents

Experimental model of escape phenomenon in hamsters and the effectiveness of YM‐53601 in the model

Syntheses of 3-Ethylidenequinuclidine derivatives as squalene synthase inhibitors. Part 2: enzyme inhibition and effects on plasma lipid levels

O-20137 A novel volume-regulated anion channel inhibitor, YM-255693, prevents ischemia-induced arrhythmia in rats

Enhancement of canine taste responses to umami substances by salts

Large enhancement of canine taste responses to amino acids by salts

Cholesterol-lowering effect of YM-16638 in cynomolgus monkeys

Synthesis and Biological Evaluation of Quinuclidine Derivatives Incorporating Phenothiazine Moieties as Squalene Synthase Inhibitors

Endogenous dopamine release induced by repetitive transcranial magnetic stimulation over the primary motor cortex: an [11C]raclopride positron emission tomography study in anesthetized macaque monkeys

Long-term effect of motor cortical repetitive transcranial magnetic stimulation induces

Long-term effect of motor cortical repetitive transcranial magnetic stimulation [correction]

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