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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5673-5698

2017

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Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration

Atherosclerosis, 2005-02, Vol.178 (2), p.271-277

2005

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Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure

Critical care medicine, 2002-10, Vol.30 (10), p.2242-2248

2002

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A simple and practical method for the stereoselective synthesis of ( Z)-1-iodo-1-alkenes from 1,1-diiodo-1-alkenes

Tetrahedron letters, 2003-11, Vol.44 (48), p.8645-8647

2003

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Continuous Hemodiafiltration in Pediatric Critical Care Patients

Therapeutic apheresis and dialysis, 2004-10, Vol.8 (5), p.390-397

2004

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Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.1001-1018

2018

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Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3753-3753

2018

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Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (19), p.5410-5414

2013

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Nicotine Enhances Human Vascular Endothelial Cell Expression of ICAM-1 and VCAM-1 Via Protein Kinase C, p38 Mitogen-Activated Protein Kinase, NF-κB, and AP-1

Cardiovascular toxicology, 2006-03, Vol.6 (1), p.39-50

2006

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Convergent synthesis of the FGHI ring segment of yessotoxin

Tetrahedron letters, 2006-01, Vol.47 (1), p.89-92

2006

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Convergent synthesis of the A–F ring segment of yessotoxin and adriatoxin

Tetrahedron letters, 2003-12, Vol.44 (50), p.8935-8938

2003

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Synthesis and structure–activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (1), p.199-202

2009

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Effectiveness of Interventions by Pharmacists in Ensuring Safety and Efficacy of Outpatient Chemotherapy Prescriptions

Iryo yakugaku, 2010, Vol.36 (12), p.880-886

2010

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Usefulness of Interleukin-6 (IL-6) Blood Level Rapid Measurement System in the Decision of the Indication of Continuous Hemodiafiltration (CHDF) for Severe Acute Pancreatitis (SAP)

Nihon Kyukyu Igakukai Zasshi, 2002/08/15, Vol.13(8), pp.411-421

2002

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Partial liquid ventilation with FC-77 suppresses the release of lipid mediators in rat acute lung injury model

Critical care medicine, 2004-10, Vol.32 (10), p.2085-2089

2004

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Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-[kappa]B, and AP-1

Cardiovascular toxicology, 2006-01, Vol.6 (1), p.39

2006

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Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1

Cardiovascular toxicology, 2006, Vol.6 (1), p.39-50

2006

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Nutritional Support for the Patient with Multiple Organ Failure in Gastroenterological Surgery

The Japanese Journal of Gastroenterological Surgery, 1993, Vol.26(4), pp.1181-1186

1993

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CONTINUOUS RENAL REPLACEMENT THERAPY (CRRT) WITHOUT ANTICOAGULANT FOR THE CRITICALLY ILL PATIENTS COMPLICATING BLEEDING TENDENCY

Critical care medicine, 1998-01, Vol.26 (Supplement), p.121

1998

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Efficacy and Limitation of Apheresis Therapy in Critical Care

Therapeutic apheresis, 1997-08, Vol.1 (3), p.228-232

1997

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CONTINUOUS HEMODIAFILTRATION (CHDF) REMOVES CYTOKINES AND IMPROVES RESPIRATORY INDEX (RI) AND OXYGEN METABOLISM IN PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)

Critical care medicine, 1998-01, Vol.26 (Supplement), p.120

1998

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Humoral mediators in the pathophysiology of organ dysfunction in sepsis

Nihon Geka Gakkai zasshi, 2003-07, Vol.104 (7), p.511

2003

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A CASE OF PERFORATION OF THE SMALL INTESTINE BY A SOFT SHELLED TURTLE'S BONE

Nihon Rinshō Geka Igakkai zasshi. [Journal of the Japanese Practical Surgeon Society, 1997, Vol.58 (10), p.2362-2366

1997

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A STUDY ON OUTCOME AND CHANGES IN SERUM HUMORAL MEDIATOR LEVELS IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS)

Shock (Augusta, Ga.), 1995-12, Vol.4 (Supplement), p.37

1995

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Convergent Synthesis of the A-F Ring Segment of Yessotoxin and Adriatoxin

ChemInform, 2004-03, Vol.35 (10), p.no-no

2004

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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration

Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure

A simple and practical method for the stereoselective synthesis of ( Z)-1-iodo-1-alkenes from 1,1-diiodo-1-alkenes

Continuous Hemodiafiltration in Pediatric Critical Care Patients

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate

Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

Nicotine Enhances Human Vascular Endothelial Cell Expression of ICAM-1 and VCAM-1 Via Protein Kinase C, p38 Mitogen-Activated Protein Kinase, NF-κB, and AP-1

Convergent synthesis of the FGHI ring segment of yessotoxin

Convergent synthesis of the A–F ring segment of yessotoxin and adriatoxin

Synthesis and structure–activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease

Effectiveness of Interventions by Pharmacists in Ensuring Safety and Efficacy of Outpatient Chemotherapy Prescriptions

Usefulness of Interleukin-6 (IL-6) Blood Level Rapid Measurement System in the Decision of the Indication of Continuous Hemodiafiltration (CHDF) for Severe Acute Pancreatitis (SAP)

Partial liquid ventilation with FC-77 suppresses the release of lipid mediators in rat acute lung injury model

Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-[kappa]B, and AP-1

Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1

Nutritional Support for the Patient with Multiple Organ Failure in Gastroenterological Surgery

CONTINUOUS RENAL REPLACEMENT THERAPY (CRRT) WITHOUT ANTICOAGULANT FOR THE CRITICALLY ILL PATIENTS COMPLICATING BLEEDING TENDENCY

Efficacy and Limitation of Apheresis Therapy in Critical Care

CONTINUOUS HEMODIAFILTRATION (CHDF) REMOVES CYTOKINES AND IMPROVES RESPIRATORY INDEX (RI) AND OXYGEN METABOLISM IN PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)

Humoral mediators in the pathophysiology of organ dysfunction in sepsis

A CASE OF PERFORATION OF THE SMALL INTESTINE BY A SOFT SHELLED TURTLE'S BONE

A STUDY ON OUTCOME AND CHANGES IN SERUM HUMORAL MEDIATOR LEVELS IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS)

Convergent Synthesis of the A-F Ring Segment of Yessotoxin and Adriatoxin

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