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Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes

Biochemical pharmacology, 2016-12, Vol.121, p.1-7

2016

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Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans

Biochemical pharmacology, 2022-03, Vol.197, p.114887-114887, Article 114887

2022

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Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans

Biochemical pharmacology, 2018-07, Vol.153, p.184-195

2018

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Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers

Drug metabolism and pharmacokinetics, 2022-06, Vol.44, p.100454-100454, Article 100454

2022

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Expression of functional sulfotransferases (SULT) 1A1, 1A3, 1B1, 1C2, 1E1, and 2A1 in common marmosets

Biochemical pharmacology, 2020-10, Vol.180, p.114189, Article 114189

2020

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Polymorphic cytochromes P450 in non-human primates

Advances in pharmacology (1990), 2022-01, Vol.95, p.329-364

2022

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Cytochrome P450 1A1, 2C9, 2C19, and 3A4 Polymorphisms Account for Interindividual Variability of Toxicological Drug Metabolism in Cynomolgus Macaques

Chemical research in toxicology, 2018-12, Vol.31 (12), p.1373-1381

2018

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Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques

Xenobiotica, 2021-04, Vol.51 (4), p.494-499

2021

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In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice

Drug metabolism and pharmacokinetics, 2021-04, Vol.37, p.100369, Article 100369

2021

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Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 1

Drug metabolism and pharmacokinetics, 2021-08, Vol.39, p.100398, Article 100398

2021

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Molecular cloning, sequence analysis, and tissue distribution of marmoset monoamine oxidases A and B

Drug metabolism and pharmacokinetics, 2020-10, Vol.35 (5), p.479-482

2020

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Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes

The Journal of Toxicological Sciences, 2021, Vol.46(7), pp.311-317

2021

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Molecular and Functional Characterization of N -Acetyltransferases in Common Marmosets and Pigs

Drug metabolism and disposition, 2022-11, Vol.50 (11), p.1429-1433

2022

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Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4′- and 5‑Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice

Chemical research in toxicology, 2020-02, Vol.33 (2), p.634-639

2020

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Molecular cloning and tissue distribution of marmoset thiopurine S-methyltransferase

Drug metabolism and pharmacokinetics, 2020-10, Vol.35 (5), p.475-478

2020

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Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone

Drug metabolism and disposition, 2017-05, Vol.45 (5), p.457-467

2017

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Forward and reverse dosimetry for aniline and 2,6-dimethylaniline in humans extrapolated from humanized-liver mouse data using simplified physiologically based pharmacokinetic models

The Journal of Toxicological Sciences, 2022, Vol.47(12), pp.531-538

2022

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Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model

Chemical research in toxicology, 2021-02, Vol.34 (2), p.522-528

2021

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Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice

The Journal of Toxicological Sciences, 2021, Vol.46(11), pp.525-530

2021

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Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation

Drug metabolism and pharmacokinetics, 2024-06, Vol.56, p.101007, Article 101007

2024

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Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential

Chemical research in toxicology, 2020-12, Vol.33 (12), p.3048-3053

2020

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Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets

Biochemical pharmacology, 2020-02, Vol.172, p.113748, Article 113748

2020

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Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques

Biochemical pharmacology, 2019-05, Vol.163, p.335-344

2019

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Cloning and tissue expression of cytochrome P450 2S1, 4V2, 7A1, 7B1, 8B1, 24A1, 26A1, 26C1, 27A1, 39A1, and 51A1 in marmosets

Drug metabolism and pharmacokinetics, 2020-04, Vol.35 (2), p.244-247

2020

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Substrate Selectivities and Catalytic Activities of Marmoset Liver Cytochrome P450 2A6 Differed from Those of Human P450 2A6

Drug metabolism and disposition, 2015-07, Vol.43 (7), p.969-976

2015

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Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes

Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans

Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans

Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers

Expression of functional sulfotransferases (SULT) 1A1, 1A3, 1B1, 1C2, 1E1, and 2A1 in common marmosets

Polymorphic cytochromes P450 in non-human primates

Cytochrome P450 1A1, 2C9, 2C19, and 3A4 Polymorphisms Account for Interindividual Variability of Toxicological Drug Metabolism in Cynomolgus Macaques

Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques

In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice

Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 1

Molecular cloning, sequence analysis, and tissue distribution of marmoset monoamine oxidases A and B

Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes

Molecular and Functional Characterization of N -Acetyltransferases in Common Marmosets and Pigs

Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4′- and 5‑Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice

Molecular cloning and tissue distribution of marmoset thiopurine S-methyltransferase

Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone

Forward and reverse dosimetry for aniline and 2,6-dimethylaniline in humans extrapolated from humanized-liver mouse data using simplified physiologically based pharmacokinetic models

Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model

Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice

Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation

Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential

Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets

Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques

Cloning and tissue expression of cytochrome P450 2S1, 4V2, 7A1, 7B1, 8B1, 24A1, 26A1, 26C1, 27A1, 39A1, and 51A1 in marmosets

Substrate Selectivities and Catalytic Activities of Marmoset Liver Cytochrome P450 2A6 Differed from Those of Human P450 2A6

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