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Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics

Clinical pharmacology and therapeutics, 2016-10, Vol.100 (4), p.362-370

2016

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Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model

Clinical pharmacology and therapeutics, 2016-11, Vol.100 (5), p.413-418

2016

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Effects of Pregnancy on CYP3A and P-glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study

Clinical pharmacology and therapeutics, 2008-08, Vol.84 (2), p.248-253

2008

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Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

Clinical pharmacology and therapeutics, 2014-02, Vol.95 (2), p.179-188

2014

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Are We Optimizing Gestational Diabetes Treatment With Glyburide? The Pharmacologic Basis for Better Clinical Practice

Clinical pharmacology and therapeutics, 2009-06, Vol.85 (6), p.607-614

2009

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Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content

The pharmacogenomics journal, 2016-08, Vol.16 (4), p.375-387

2016

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The concept of fraction of drug transported (ft) with special emphasis on BBB efflux of CNS and antiretroviral drugs

Clinical pharmacology and therapeutics, 2015-04, Vol.97 (4), p.320-323

2015

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Regional P-Glycoprotein Activity and Inhibition at the Human Blood-Brain Barrier as Imaged by Positron Emission Tomography

Clinical pharmacology and therapeutics, 2010-05, Vol.87 (5), p.579-585

2010

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A PBPK Model to Predict Disposition of CYP3A‐Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction

CPT: pharmacometrics and systems pharmacology, 2012-09, Vol.1 (9), p.1-10

2012

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Positron emission tomography imaging of tissue P‐glycoprotein activity during pregnancy in the non‐human primate

British journal of pharmacology, 2010-01, Vol.159 (2), p.394-404

2010

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Grapefruit Juice, a Glass Full of Drug Interactions?

Clinical pharmacology and therapeutics, 2007-05, Vol.81 (5), p.631-633

2007

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Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities

Drug metabolism and disposition, 1998-03, Vol.26 (3), p.207

1998

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Expression of arylamine N-acetyltransferase in human intestine

Gut, 1998-03, Vol.42 (3), p.402-409

1998

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Molecular Requirements of the Human Nucleoside Transporters hCNT1, hCNT2, and hENT1

Molecular pharmacology, 2004-03, Vol.65 (3), p.558-570

2004

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CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone

Drug metabolism and disposition, 2000-08, Vol.28 (8), p.865

2000

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Intestinal absorption of ribavirin is preferentially mediated by the Na+-nucleoside purine (N1) transporter

Pharmaceutical research, 1998-06, Vol.15 (6), p.950-952

1998

Volltextzugriff (PDF)

The role of transporters in drug interactions

European journal of pharmaceutical sciences, 2006-04, Vol.27 (5), p.501-517

2006

Volltextzugriff (PDF)

Grapefruit Juice, a Glass Full of Drug Interactions?

Clinical pharmacology and therapeutics, 2007-05, Vol.81 (5), p.631-633

2007

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Mitochondrial Expression of the Human Equilibrative Nucleoside Transporter 1 (hENT1) Results in Enhanced Mitochondrial Toxicity of Antiviral Drugs

The Journal of biological chemistry, 2004-02, Vol.279 (6), p.4490-4497

2004

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Sodium-dependent nucleoside transport in the human intestinal brush-border membrane

American journal of physiology: Gastrointestinal and liver physiology, 1997-06, Vol.272 (6), p.G1314-G1320

1997

Volltextzugriff (PDF)

In vitro models to predict the in vivo mechanism, rate, and extent of placental transfer of dideoxynucleoside drugs against human immunodeficiency virus

American journal of obstetrics and gynecology, 1999, Vol.180 (1), p.198-206

1999

Volltextzugriff (PDF)

Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics

Drug metabolism and disposition, 2016-11, Vol.44 (11), p.1752-1758

2016

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Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo

Clinical pharmacology and therapeutics, 1995-11, Vol.58 (5), p.556-566

1995

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CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.750-757

2016

Volltextzugriff (PDF)

Functional expression of human intestinal Na +-dependent and Na +-independent nucleoside transporters in Xenopus laevis oocytes

Biochemical pharmacology, 1997-06, Vol.53 (12), p.1909-1918

1997

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Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics

Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model

Effects of Pregnancy on CYP3A and P-glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study

Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

Are We Optimizing Gestational Diabetes Treatment With Glyburide? The Pharmacologic Basis for Better Clinical Practice

Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content

The concept of fraction of drug transported (ft) with special emphasis on BBB efflux of CNS and antiretroviral drugs

Regional P-Glycoprotein Activity and Inhibition at the Human Blood-Brain Barrier as Imaged by Positron Emission Tomography

A PBPK Model to Predict Disposition of CYP3A‐Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction

Positron emission tomography imaging of tissue P‐glycoprotein activity during pregnancy in the non‐human primate

Grapefruit Juice, a Glass Full of Drug Interactions?

Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities

Expression of arylamine N-acetyltransferase in human intestine

Molecular Requirements of the Human Nucleoside Transporters hCNT1, hCNT2, and hENT1

CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone

Intestinal absorption of ribavirin is preferentially mediated by the Na+-nucleoside purine (N1) transporter

The role of transporters in drug interactions

Grapefruit Juice, a Glass Full of Drug Interactions?

Mitochondrial Expression of the Human Equilibrative Nucleoside Transporter 1 (hENT1) Results in Enhanced Mitochondrial Toxicity of Antiviral Drugs

Sodium-dependent nucleoside transport in the human intestinal brush-border membrane

In vitro models to predict the in vivo mechanism, rate, and extent of placental transfer of dideoxynucleoside drugs against human immunodeficiency virus

Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics

Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo

CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids

Functional expression of human intestinal Na +-dependent and Na +-independent nucleoside transporters in Xenopus laevis oocytes

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