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Approach To Evaluating Dried Blood Spot Sample Stability during Drying Process and Discovery of a Treated Card To Maintain Analyte Stability by Rapid On-Card pH Modification

Analytical chemistry (Washington), 2011-12, Vol.83 (23), p.9033-9038

2011

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Characterization of disulfide linkages in recombinant human granulocyte-colony stimulating factor

Rapid communications in mass spectrometry, 2013-05, Vol.27 (9), p.940-946

2013

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Optimization and Simulation of Tandem Column Supercritical Fluid Chromatography Separations Using Column Back Pressure as a Unique Parameter

Analytical chemistry (Washington), 2014-04, Vol.86 (8), p.4033-4040

2014

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Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

Drug discovery today, 2014-01, Vol.19 (1), p.95-102

2014

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A Tris (2-Carboxyethyl) Phosphine (TCEP) Related Cleavage on Cysteine-Containing Proteins

Journal of the American Society for Mass Spectrometry, 2010-05, Vol.21 (5), p.837-844

2010

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Fast Photochemical Oxidation of Proteins (FPOP) Maps the Epitope of EGFR Binding to Adnectin

Journal of the American Society for Mass Spectrometry, 2014-12, Vol.25 (12), p.2084-2092

2014

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Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis

Analytical chemistry (Washington), 2017-02, Vol.89 (4), p.2250-2258

2017

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Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL‑6 Receptor upon Binding of Protein Therapeutics

Analytical chemistry (Washington), 2017-07, Vol.89 (14), p.7742-7749

2017

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The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton’s tyrosine kinase

Journal of Chromatography A, 2017-03, Vol.1487, p.116-128

2017

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Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry

Journal of the American Society for Mass Spectrometry, 2018-01, Vol.29 (1), p.174-182

2018

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Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography with stable-isotope labeling mass spectrometry

Journal of Chromatography A, 2015-12, Vol.1426, p.133-139

2015

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Structural mass spectrometry in biologics discovery: advances and future trends

Drug discovery today, 2012-12, Vol.17 (23-24), p.1323-1330

2012

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High-resolution MS for structural characterization of protein therapeutics: advances and future directions

Bioanalysis, 2013-05, Vol.5 (10), p.1299-1313

2013

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Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates

Journal of the American Society for Mass Spectrometry, 2015-10, Vol.26 (10), p.1791-1794

2015

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Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry

Journal of the American Society for Mass Spectrometry, 2017-05, Vol.28 (5), p.795-802

2017

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Enantioselective chromatography in drug discovery

Drug Discovery Today, 2005-04, Vol.10 (8), p.571-577

2005

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Characterization of protein therapeutics by mass spectrometry: recent developments and future directions

Drug discovery today, 2011, Vol.16 (1), p.58-64

2011

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Development and implementation of a stereoselective normal-phase liquid chromatography–tandem mass spectrometry method for the determination of intrinsic metabolic clearance in human liver microsomes

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-11, Vol.875 (1), p.154-160

2008

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Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates

Journal of Chromatography A, 2016-07, Vol.1455, p.133-139

2016

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Development of a highly sensitive liquid chromatography/tandem mass spectrometry method to quantify total and free levels of a target protein, interferon-gamma-inducible protein-10, at picomolar levels in human serum

Rapid communications in mass spectrometry, 2014-07, Vol.28 (13), p.1535-1543

2014

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Metabolomics in the pharmaceutical industry

Drug discovery today. Technologies, 2015-06, Vol.13, p.25-31

2015

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Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development

Journal of organic chemistry, 2015-07, Vol.80 (14), p.7019-7032

2015

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The Influence of Adnectin Binding on the Extracellular Domain of Epidermal Growth Factor Receptor

Journal of the American Society for Mass Spectrometry, 2014-12, Vol.25 (12), p.2093-2102

2014

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Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development

Journal of pharmaceutical and biomedical analysis, 2017-05, Vol.138, p.166-174

2017

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Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics

Expert review of proteomics, 2015-04, Vol.12 (2), p.159-169

2015

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Approach To Evaluating Dried Blood Spot Sample Stability during Drying Process and Discovery of a Treated Card To Maintain Analyte Stability by Rapid On-Card pH Modification

Characterization of disulfide linkages in recombinant human granulocyte-colony stimulating factor

Optimization and Simulation of Tandem Column Supercritical Fluid Chromatography Separations Using Column Back Pressure as a Unique Parameter

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

A Tris (2-Carboxyethyl) Phosphine (TCEP) Related Cleavage on Cysteine-Containing Proteins

Fast Photochemical Oxidation of Proteins (FPOP) Maps the Epitope of EGFR Binding to Adnectin

Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis

Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL‑6 Receptor upon Binding of Protein Therapeutics

The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton’s tyrosine kinase

Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry

Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography with stable-isotope labeling mass spectrometry

Structural mass spectrometry in biologics discovery: advances and future trends

High-resolution MS for structural characterization of protein therapeutics: advances and future directions

Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates

Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry

Enantioselective chromatography in drug discovery

Characterization of protein therapeutics by mass spectrometry: recent developments and future directions

Development and implementation of a stereoselective normal-phase liquid chromatography–tandem mass spectrometry method for the determination of intrinsic metabolic clearance in human liver microsomes

Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates

Development of a highly sensitive liquid chromatography/tandem mass spectrometry method to quantify total and free levels of a target protein, interferon-gamma-inducible protein-10, at picomolar levels in human serum

Metabolomics in the pharmaceutical industry

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development

The Influence of Adnectin Binding on the Extracellular Domain of Epidermal Growth Factor Receptor

Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development

Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics

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